eF-site ID 6c19-A PDB Code 6c19 Chain A click to enlarge Title FGFR1 kinase complex with inhibitor SN36985 Classification Transferase/Transferase inhibitor Compound Fibroblast growth factor receptor 1 Source (FGFR1_HUMAN) Sequence A:  ELPEDPRWELPRDRLVLGKPLGEQVVLAEAIGLDKDKPNR VTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINL LGACTQDGPLYVIVEYASKGNLREYLQARRPPEYSYNPSE EQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT EDNVMKIADFGLLPVKWMAPEALFDRIYTHQSDVWSFGVL LWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNEL YMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQE Description Functional site 1) chain A residue 484 type sequence L description binding site for residue YY7 A 801 source : AC1 2) chain A residue 492 type sequence V description binding site for residue YY7 A 801 source : AC1 3) chain A residue 512 type sequence A description binding site for residue YY7 A 801 source : AC1 4) chain A residue 514 type sequence K description binding site for residue YY7 A 801 source : AC1 5) chain A residue 531 type sequence E description binding site for residue YY7 A 801 source : AC1 6) chain A residue 535 type sequence M description binding site for residue YY7 A 801 source : AC1 7) chain A residue 559 type sequence V description binding site for residue YY7 A 801 source : AC1 8) chain A residue 561 type sequence V description binding site for residue YY7 A 801 source : AC1 9) chain A residue 562 type sequence E description binding site for residue YY7 A 801 source : AC1 10) chain A residue 564 type sequence A description binding site for residue YY7 A 801 source : AC1 11) chain A residue 568 type sequence N description binding site for residue YY7 A 801 source : AC1 12) chain A residue 571 type sequence E description binding site for residue YY7 A 801 source : AC1 13) chain A residue 630 type sequence L description binding site for residue YY7 A 801 source : AC1 14) chain A residue 640 type sequence A description binding site for residue YY7 A 801 source : AC1 15) chain A residue 641 type sequence D description binding site for residue YY7 A 801 source : AC1 16) chain A residue 539 type sequence G description binding site for residue SO4 A 802 source : AC2 17) chain A residue 540 type sequence K description binding site for residue SO4 A 802 source : AC2 18) chain A residue 618 type sequence K description binding site for residue SO4 A 802 source : AC2 19) chain A residue 564 type BINDING sequence A description source Swiss-Prot : SWS_FT_FI2 20) chain A residue 570 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI2 21) chain A residue 629 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI2 22) chain A residue 643 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 23) chain A residue 486 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 24) chain A residue 516 type BINDING sequence L description source Swiss-Prot : SWS_FT_FI2 25) chain A residue 625 type ACT_SITE sequence A description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028, ECO:0000269|PubMed:19224897 source Swiss-Prot : SWS_FT_FI1 26) chain A residue 465 type MOD_RES sequence L description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16507368, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:8622701 source Swiss-Prot : SWS_FT_FI3 27) chain A residue 585 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16507368, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:8622701 source Swiss-Prot : SWS_FT_FI3 28) chain A residue 587 type MOD_RES sequence P description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16507368, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:8622701 source Swiss-Prot : SWS_FT_FI3 29) chain A residue 732 type MOD_RES sequence M description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:8622701 source Swiss-Prot : SWS_FT_FI5 30) chain A residue 484-514 type prosite sequence LGEQVVLAEAIGLDKDKPNRVTKVAVK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFGQVVlAeaigldkdkpnrvtk...VAVK source prosite : PS00107 31) chain A residue 619-631 type prosite sequence CIHRDLAARNVLV description PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNVLV source prosite : PS00109

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