eF-site ID 6c12-ABCD PDB Code 6c12 Chain A, B, C, D click to enlarge Title SDHA-SDHE complex Classification Oxidoreductase/Chaperon Compound Succinate dehydrogenase flavoprotein subunit Source (SDHE_ECOLI) Sequence A:  MKLPVREFDAVVIGAGGAGMRAALQISQSGQTCALLSKVF PTRSHTVSAQGHMYDTVKGSDYIGDQDAIEYMCKTGPEAI LELEHMGLPFADRTGHALLHTLYQQNLKNHTTIFSEWYAL DLVKNQDGAVVGCTALCIETGEVVYFKARATVLATGGAGR IYQSTTNAHINTGDGVGMAIRAGVPVQDMEMWQFHPTGIA GAGVLVTEGCRGEGGYLLNKHGERFMERYAPNAKDLAGRD VVARSIMIEIREGRGCDGPWGPHAKLKLDHLGKEVLESRL PGILELSRTFAHVDPVKEPIPVIPTCHYMMGGIPTKVTGQ ALTVNEKGEDVVVPGLFAVGEIACVSVHGANRLGGNSLLD LVVFGRAAGLHLQESIAEQGALRDASESDVEASLDRLNRW NNNRNGEDPVAIRKALQECMQHNFSVFREGDAMAKGLEQL KVIRERLKNARLDDTSSEFNTQRVECLELDNLMETAYATA VSANFRTESRGAHSRFDFPDRDDENWLCHSLYLPESESMT RRSVNMEPKLRPAFPP B:  MKLPVREFDAVVIGAGGAGMRAALQISQSGQTCALLSKVF PTRSHTVSAQGGNWEWHMYDTVKGSDYIGDQDAIEYMCKT GPEAILELEHMADRTGHALLHTLYQQNLKNHTTIFSEWYA LDLVKNQDGAVVGCTALCIETGEVVYFKARATVLATGGAG RIYQSTTNAHINTGDGVGMAIRAGVPVQDMEMWQFHPTGI AGAGVLVTEGCRGEGGYLLNKHGERFMERYAPNAKDLAGR DVVARSIMIEIREGRGCDGPWGPHAKLKLDHLGKEVLESR LPGILELSRTFAHVDPVKEPIPVIPTCHYMMGGIPTKVTG QALTVNEKGEDVVVPGLFAVGEIACVSVHGANRLGGNSLL DLVVFGRAAGLHLQESIAEQGALRDASESDVEASLDRLNR WNNNRNGEDPVAIRKALQECMQHNFSVFREGDAMAKGLEQ LKVIRERLKNARLDDTSSEFNTQRVECLELDNLMETAYAT AVSANFRTESRGAHSRFDFPDRDDENWLCHSLYLPESESM TRRSVNMEPKLRPAFPP C:  DINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKR IFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRNR ERGPV D:  DINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKR IFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRNR ERGPVA Description Functional site 1) chain B residue 14 type sequence G description binding site for residue FAD B 601 source : AC1 2) chain B residue 15 type sequence A description binding site for residue FAD B 601 source : AC1 3) chain B residue 16 type sequence G description binding site for residue FAD B 601 source : AC1 4) chain B residue 17 type sequence G description binding site for residue FAD B 601 source : AC1 5) chain B residue 18 type sequence A description binding site for residue FAD B 601 source : AC1 6) chain B residue 37 type sequence S description binding site for residue FAD B 601 source : AC1 7) chain B residue 38 type sequence K description binding site for residue FAD B 601 source : AC1 8) chain B residue 39 type sequence V description binding site for residue FAD B 601 source : AC1 9) chain B residue 44 type sequence S description binding site for residue FAD B 601 source : AC1 10) chain B residue 45 type sequence H description binding site for residue FAD B 601 source : AC1 11) chain B residue 46 type sequence T description binding site for residue FAD B 601 source : AC1 12) chain B residue 48 type sequence S description binding site for residue FAD B 601 source : AC1 13) chain B residue 49 type sequence A description binding site for residue FAD B 601 source : AC1 14) chain B residue 50 type sequence Q description binding site for residue FAD B 601 source : AC1 15) chain B residue 164 type sequence W description binding site for residue FAD B 601 source : AC1 16) chain B residue 165 type sequence Y description binding site for residue FAD B 601 source : AC1 17) chain B residue 166 type sequence A description binding site for residue FAD B 601 source : AC1 18) chain B residue 201 type sequence A description binding site for residue FAD B 601 source : AC1 19) chain B residue 202 type sequence T description binding site for residue FAD B 601 source : AC1 20) chain B residue 203 type sequence G description binding site for residue FAD B 601 source : AC1 21) chain B residue 213 type sequence T description binding site for residue FAD B 601 source : AC1 22) chain B residue 214 type sequence N description binding site for residue FAD B 601 source : AC1 23) chain B residue 221 type sequence D description binding site for residue FAD B 601 source : AC1 24) chain B residue 354 type sequence H description binding site for residue FAD B 601 source : AC1 25) chain B residue 355 type sequence Y description binding site for residue FAD B 601 source : AC1 26) chain B residue 387 type sequence G description binding site for residue FAD B 601 source : AC1 27) chain B residue 388 type sequence E description binding site for residue FAD B 601 source : AC1 28) chain B residue 402 type sequence G description binding site for residue FAD B 601 source : AC1 29) chain B residue 404 type sequence S description binding site for residue FAD B 601 source : AC1 30) chain B residue 405 type sequence L description binding site for residue FAD B 601 source : AC1 31) chain B residue 408 type sequence L description binding site for residue FAD B 601 source : AC1 32) chain B residue 356 type sequence M description binding site for residue NA B 602 source : AC2 33) chain B residue 357 type sequence M description binding site for residue NA B 602 source : AC2 34) chain B residue 358 type sequence G description binding site for residue NA B 602 source : AC2 35) chain B residue 388 type sequence E description binding site for residue NA B 602 source : AC2 36) chain B residue 390 type sequence A description binding site for residue NA B 602 source : AC2 37) chain A residue 356 type sequence M description binding site for residue NA A 602 source : AC3 38) chain A residue 357 type sequence M description binding site for residue NA A 602 source : AC3 39) chain A residue 358 type sequence G description binding site for residue NA A 602 source : AC3 40) chain A residue 388 type sequence E description binding site for residue NA A 602 source : AC3 41) chain A residue 390 type sequence A description binding site for residue NA A 602 source : AC3 42) chain A residue 14 type sequence G description binding site for Di-peptide FAD A 601 and HIS A 45 source : AC4 43) chain A residue 15 type sequence A description binding site for Di-peptide FAD A 601 and HIS A 45 source : AC4 44) chain A residue 16 type sequence G description binding site for Di-peptide FAD A 601 and HIS A 45 source : AC4 45) chain A residue 17 type sequence G description binding site for Di-peptide FAD A 601 and HIS A 45 source : AC4 46) chain A residue 18 type sequence A description binding site for Di-peptide FAD A 601 and HIS A 45 source : AC4 47) chain A residue 37 type sequence S description binding site for Di-peptide FAD A 601 and HIS A 45 source : AC4 48) chain A residue 38 type sequence K description binding site for Di-peptide FAD A 601 and HIS A 45 source : AC4 49) chain A residue 39 type sequence V description binding site for Di-peptide FAD A 601 and HIS A 45 source : AC4 50) chain A residue 44 type sequence S description binding site for Di-peptide FAD A 601 and HIS A 45 source : AC4 51) chain A residue 46 type sequence T description binding site for Di-peptide FAD A 601 and HIS A 45 source : AC4 52) chain A residue 47 type sequence V description binding site for Di-peptide FAD A 601 and HIS A 45 source : AC4 53) chain A residue 48 type sequence S description binding site for Di-peptide FAD A 601 and HIS A 45 source : AC4 54) chain A residue 49 type sequence A description binding site for Di-peptide FAD A 601 and HIS A 45 source : AC4 55) chain A residue 50 type sequence Q description binding site for Di-peptide FAD A 601 and HIS A 45 source : AC4 56) chain A residue 51 type sequence G description binding site for Di-peptide FAD A 601 and HIS A 45 source : AC4 57) chain A residue 164 type sequence W description binding site for Di-peptide FAD A 601 and HIS A 45 source : AC4 58) chain A residue 165 type sequence Y description binding site for Di-peptide FAD A 601 and HIS A 45 source : AC4 59) chain A residue 166 type sequence A description binding site for Di-peptide FAD A 601 and HIS A 45 source : AC4 60) chain A residue 201 type sequence A description binding site for Di-peptide FAD A 601 and HIS A 45 source : AC4 61) chain A residue 202 type sequence T description binding site for Di-peptide FAD A 601 and HIS A 45 source : AC4 62) chain A residue 203 type sequence G description binding site for Di-peptide FAD A 601 and HIS A 45 source : AC4 63) chain A residue 213 type sequence T description binding site for Di-peptide FAD A 601 and HIS A 45 source : AC4 64) chain A residue 214 type sequence N description binding site for Di-peptide FAD A 601 and HIS A 45 source : AC4 65) chain A residue 215 type sequence A description binding site for Di-peptide FAD A 601 and HIS A 45 source : AC4 66) chain A residue 221 type sequence D description binding site for Di-peptide FAD A 601 and HIS A 45 source : AC4 67) chain A residue 354 type sequence H description binding site for Di-peptide FAD A 601 and HIS A 45 source : AC4 68) chain A residue 355 type sequence Y description binding site for Di-peptide FAD A 601 and HIS A 45 source : AC4 69) chain A residue 387 type sequence G description binding site for Di-peptide FAD A 601 and HIS A 45 source : AC4 70) chain A residue 388 type sequence E description binding site for Di-peptide FAD A 601 and HIS A 45 source : AC4 71) chain A residue 402 type sequence G description binding site for Di-peptide FAD A 601 and HIS A 45 source : AC4 72) chain A residue 404 type sequence S description binding site for Di-peptide FAD A 601 and HIS A 45 source : AC4 73) chain A residue 405 type sequence L description binding site for Di-peptide FAD A 601 and HIS A 45 source : AC4 74) chain A residue 408 type sequence L description binding site for Di-peptide FAD A 601 and HIS A 45 source : AC4 75) chain C residue 16 type sequence G description binding site for Di-peptide FAD A 601 and HIS A 45 source : AC4 76) chain B residue 267 type MOD_RES sequence K description N6-acetyllysine => ECO:0000269|PubMed:18723842 source Swiss-Prot : SWS_FT_FI5 77) chain A residue 267 type MOD_RES sequence K description N6-acetyllysine => ECO:0000269|PubMed:18723842 source Swiss-Prot : SWS_FT_FI5 78) chain B residue 43-52 type prosite sequence RSHTVSAQGG description FRD_SDH_FAD_BINDING Fumarate reductase / succinate dehydrogenase FAD-binding site. RSHTvsAqGG source prosite : PS00504 79) chain B residue 354 type BINDING sequence H description BINDING => ECO:0000269|PubMed:19710024 source Swiss-Prot : SWS_FT_FI3 80) chain B residue 399 type BINDING sequence R description BINDING => ECO:0000269|PubMed:19710024 source Swiss-Prot : SWS_FT_FI3 81) chain A residue 242 type BINDING sequence H description BINDING => ECO:0000269|PubMed:19710024 source Swiss-Prot : SWS_FT_FI3 82) chain A residue 254 type BINDING sequence T description BINDING => ECO:0000269|PubMed:19710024 source Swiss-Prot : SWS_FT_FI3 83) chain A residue 354 type BINDING sequence H description BINDING => ECO:0000269|PubMed:19710024 source Swiss-Prot : SWS_FT_FI3 84) chain A residue 399 type BINDING sequence R description BINDING => ECO:0000269|PubMed:19710024 source Swiss-Prot : SWS_FT_FI3 85) chain B residue 242 type BINDING sequence H description BINDING => ECO:0000269|PubMed:19710024 source Swiss-Prot : SWS_FT_FI3 86) chain B residue 254 type BINDING sequence T description BINDING => ECO:0000269|PubMed:19710024 source Swiss-Prot : SWS_FT_FI3 87) chain B residue 45 type MOD_RES sequence H description Tele-8alpha-FAD histidine => ECO:0000269|PubMed:12560550, ECO:0000269|PubMed:16407191, ECO:0000269|PubMed:19710024 source Swiss-Prot : SWS_FT_FI4 88) chain A residue 45 type MOD_RES sequence H description Tele-8alpha-FAD histidine => ECO:0000269|PubMed:12560550, ECO:0000269|PubMed:16407191, ECO:0000269|PubMed:19710024 source Swiss-Prot : SWS_FT_FI4 89) chain B residue 286 type ACT_SITE sequence R description Proton acceptor => ECO:0000269|PubMed:19710024 source Swiss-Prot : SWS_FT_FI1 90) chain A residue 286 type ACT_SITE sequence R description Proton acceptor => ECO:0000269|PubMed:19710024 source Swiss-Prot : SWS_FT_FI1 91) chain B residue 221 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12560550, ECO:0000269|PubMed:16407191, ECO:0000269|PubMed:19710024 source Swiss-Prot : SWS_FT_FI2 92) chain B residue 388 type BINDING sequence E description BINDING => ECO:0000269|PubMed:12560550, ECO:0000269|PubMed:16407191, ECO:0000269|PubMed:19710024 source Swiss-Prot : SWS_FT_FI2 93) chain B residue 14 type BINDING sequence G description BINDING => ECO:0000269|PubMed:12560550, ECO:0000269|PubMed:16407191, ECO:0000269|PubMed:19710024 source Swiss-Prot : SWS_FT_FI2 94) chain B residue 37 type BINDING sequence S description BINDING => ECO:0000269|PubMed:12560550, ECO:0000269|PubMed:16407191, ECO:0000269|PubMed:19710024 source Swiss-Prot : SWS_FT_FI2 95) chain B residue 404 type BINDING sequence S description BINDING => ECO:0000269|PubMed:12560550, ECO:0000269|PubMed:16407191, ECO:0000269|PubMed:19710024 source Swiss-Prot : SWS_FT_FI2 96) chain A residue 14 type BINDING sequence G description BINDING => ECO:0000269|PubMed:12560550, ECO:0000269|PubMed:16407191, ECO:0000269|PubMed:19710024 source Swiss-Prot : SWS_FT_FI2 97) chain A residue 37 type BINDING sequence S description BINDING => ECO:0000269|PubMed:12560550, ECO:0000269|PubMed:16407191, ECO:0000269|PubMed:19710024 source Swiss-Prot : SWS_FT_FI2 98) chain A residue 221 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12560550, ECO:0000269|PubMed:16407191, ECO:0000269|PubMed:19710024 source Swiss-Prot : SWS_FT_FI2 99) chain A residue 388 type BINDING sequence E description BINDING => ECO:0000269|PubMed:12560550, ECO:0000269|PubMed:16407191, ECO:0000269|PubMed:19710024 source Swiss-Prot : SWS_FT_FI2 100) chain A residue 404 type BINDING sequence S description BINDING => ECO:0000269|PubMed:12560550, ECO:0000269|PubMed:16407191, ECO:0000269|PubMed:19710024 source Swiss-Prot : SWS_FT_FI2

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