eF-site ID 6c07-ABCD
PDB Code 6c07
Chain A, B, C, D

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Title Crystal Structure of S-Adenosylmethionine synthetase (MetK/Mat) from Cryptosporidium parvum
Classification TRANSFERASE
Compound S-adenosylmethionine synthase
Source (Q5CYE4_CRYPI)
Sequence A:  EQFLFSSESVCSGHPDKLCDQISDAILDACLEQDPESFVA
CETCTKTGFIMVFGEITTKANVNYERVVRETVKEIGYDSE
EKGLDYKTMDVIIKLEQQDKNVEDIGAGDQGMMFGYATNE
TKELMPLTHVLATSITRELDYIRVKGVSSRVGWLRPDGKA
QVTVEYNCKHGVLIPKRIHTILVSVQHDENIENEEIREFV
LENVIKKVCPSDLMDKETRILINPSGRFTIGGPAADAGLT
GRKIIVDTYGGWGAHGGGAFSGKDATKVDRSGAYMARLVA
KSIVFSGLCSRCLVQVSYGIGIARPLSLYINTFGTAKDGY
NDAKLLEIVNKVFDFRPGILIKQLNLKSPIFKKTSSGGHF
GRSEEEFLWEKPIILQ
B:  QFLFSSESVCSGHPDKLCDQISDAILDACLEQDPESFVAC
ETCTKTGFIMVFGEITTKANVNYERVVRETVKEIGYDSEE
KGLDYKTMDVIIKLEQQKNVEDIGAGDQGMMFGYATNETK
ELMPLTHVLATSITRELDYIRVKGWLRPDGKAQVTVEYNC
KHGVLIPKRIHTILVSVQHDENIENEEIREFVLENVIKKV
CPSDLMDKETRILINPSGRFTIGGPAADAGLTGRKIIVDT
YGGWGAHGGGAFSGKDATKVDRSGAYMARLVAKSIVFSGL
CSRCLVQVSYGIGIARPLSLYINTFGTAKDGYNDAKLLEI
VNKVFDFRPGILIKQLNLKSPIFKKTSSGGHFGRSEEEFL
WEKPIILQ
C:  EQFLFSSESVCSGHPDKLCDQISDAILDACLEQDPESFVA
CETCTKTGFIMVFGEITTKANVNYERVVRETVKEIGYDSE
EKGLDYKTMDVIIKLEQQNVEDIGAGDQGMMFGYATNETK
ELMPLTHVLATSITRELDYIRVKGVSSRVGWLRPDGKAQV
TVEYNCKHGVLIPKRIHTILVSVQHDENIENEEIREFVLE
NVIKKVCPSDLMDKETRILINPSGRFTIGGPAADAGLTGR
KIIVDTYGGWGAHGGGAFSGKDATKVDRSGAYMARLVAKS
IVFSGLCSRCLVQVSYGIGIARPLSLYINTFGTAKDGYND
AKLLEIVNKVFDFRPGILIKQLNLKSPIFKKTSSGGHFGR
SEEEFLWEKPIILQ
D:  FLFSSESVCSGHPDKLCDQISDAILDACLEQDPESFVACE
TCTKTGFIMVFGEITTKANVNYERVVRETVKEIGYDSEEK
GLDYKTMDVIIKLEQDIGAGDQGMMFGYATNETKELMPLT
HVLATSITRELDYIRVKGVSSRVGWLRPDGKAQVTVEYNC
KHGVLIPKRIHTILVSVQHDENIENEEIREFVLENVIKKV
CPSDLMDKETRILINPSGRFTIGGPAADAGLTGRKIIVDT
YGGWGAHGGGAFSGKDATKVDRSGAYMARLVAKSIVFSGL
CSRCLVQVSYGIGIARPLSLYINTFGTAKDGYNDAKLLEI
VNKVFDFRPGILIKQLNLKSPIFKKTSSGGHFGRSEEEFL
WEKPIILQ
Description


Functional site

1) chain A
residue 288
type
sequence G
description binding site for residue CL A 501
source : AC1

2) chain A
residue 289
type
sequence A
description binding site for residue CL A 501
source : AC1

3) chain A
residue 293
type
sequence K
description binding site for residue CL A 501
source : AC1

4) chain B
residue 272
type
sequence R
description binding site for residue CL A 501
source : AC1

5) chain A
residue 266
type
sequence D
description binding site for residue MG A 502
source : AC2

6) chain A
residue 267
type
sequence A
description binding site for residue MG A 502
source : AC2

7) chain A
residue 139
type
sequence D
description binding site for residue MG A 503
source : AC3

8) chain B
residue 182
type
sequence G
description binding site for residue MG B 501
source : AC4

9) chain B
residue 266
type
sequence D
description binding site for residue MG B 502
source : AC5

10) chain B
residue 267
type
sequence A
description binding site for residue MG B 502
source : AC5

11) chain C
residue 271
type
sequence G
description binding site for residue K C 501
source : AC6

12) chain D
residue 271
type
sequence G
description binding site for residue K C 501
source : AC6

13) chain C
residue 34
type
sequence H
description binding site for residue CL C 502
source : AC7

14) chain C
residue 189
type
sequence K
description binding site for residue CL C 502
source : AC7

15) chain C
residue 273
type
sequence K
description binding site for residue CL C 502
source : AC7

16) chain C
residue 266
type
sequence D
description binding site for residue MG C 503
source : AC8

17) chain C
residue 267
type
sequence A
description binding site for residue MG C 503
source : AC8

18) chain C
residue 139
type
sequence D
description binding site for residue MG C 504
source : AC9

19) chain D
residue 36
type
sequence D
description binding site for residue MG D 501
source : AD1

20) chain D
residue 273
type
sequence K
description binding site for residue MG D 501
source : AD1

21) chain A
residue 254-263
type prosite
sequence PSGRFTIGGP
description AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. P..SGrFTIGGP
source prosite : PS00178

22) chain A
residue 136-146
type prosite
sequence GAGDQGMMFGY
description ADOMET_SYNTHASE_1 S-adenosylmethionine synthase signature 1. GAGDQGmmfGY
source prosite : PS00376

23) chain A
residue 286-294
type prosite
sequence GGGAFSGKD
description ADOMET_SYNTHASE_2 S-adenosylmethionine synthase signature 2. GGGAFSgKD
source prosite : PS00377


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