eF-site ID 6c06-D PDB Code 6c06 Chain D click to enlarge Title Mycobacterium tuberculosis RNAP Holo/RbpA/Fidaxomicin Classification transcription/antibiotic Compound DNA-directed RNA polymerase subunit alpha Source Mycobacterium tuberculosis (A0A045IP01_MYCTX) Sequence D:  VNFFDELRIGLATAEDIRQWSYGEVKKPETINYRTLKPEK DGLFCEKIFGPTRDWECYCGKYKRVRFKGIICERCGVEVT RAKVRRERMGHIELAAPVTHIWYFKGVPSRLGYLLDLAPK DLEKIIYFAAYVITSVDEEMRHNELSTLEAEMAVERKAVE DQRDGELEARAQKLEADLAELEAEGAKADARRKVRDGGER EMRQIRDRAQRELDRLEDIWSTFTKLAPKQLIVDENLYRE LVDRYGEYFTGAMGAESIQKLIENFDIDAEAESLRDVIRN GKGQKKLRALKRLKVVAAFQQSGNSPMGMVLDAVPVIPPE LRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLIDLGAP EIIVNNEKRMLQESVDALFDNGRRGRPVTGPGNRPLKSLS DLLKGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCGL PKLMALELFKPFVMKRLVDLNHAQNIKSAKRMVERQRPQV WDVLEEVIAEHPVLLNRAPTLHRLGIQAFEPMLVEGKAIQ LHPLVCEAFNADFDGDQMAVHLPLSAEAQAEARILMLSSN NILSPASGRPLAMPRLDMVTGLYYLTTEVPGDTGEYQPAS GDHPETGVYSSPAEAIMAADRGVLSVRAKIKVRLTQLRPP VEIEAELFGHSGWQPGDAWMAETTLGRVMFNELLPLGYPF VNKQMHKKVQAAIINDLAERYPMIVVAQTVDKLKDAGFYW ATRSGVTVSMADVLVPPRKKEILDHYEERADKVEKQFQRG ALNHDERNEALVEIWKEATDEVGQALREHYPDDNPIITIV DSGATGNFTQTRTLAGMKGLVTNPKGEFIPRPVKSSFREG LTVLEYFINTHGARKGLADTALRTADSGYLTRRLVDVSQD VIVREHDCQTERGIVVELAERAPDGTLIRDPYIETSAYAR TLGTDAVDEAGNVIVERGQDLGDPEIDALLAAGITQVKVR SVLTCATSTGVCATCYGRSMATGKLVDIGEAVGIVAAQSI GEPGTQLTMITGGLPRVQELFEARVPRGKAPIADVTGRVR LEDGERFYKITIVPDDGGEEVVYDKISKRQRLRVFKERVL SDGDHVEVGQQLMEGSADPHEVLRVQGPREVQIHLVREVQ EVYRAQGVSIHDKHIEVIVRQMLRRVTIIDSGSTEFLPGS LIDRAEFEAENRRVVAEGGEPAAGRPVLMGITKASLATDS WLSAASFQETTRVLTDAAINCRSDKLNGLKENVIIGKLIP AGTGINRYRNIAVQPTEEARAAA Description Functional site 1) chain D residue 891 type sequence C description binding site for residue ZN D 1401 source : AC1 2) chain D residue 968 type sequence C description binding site for residue ZN D 1401 source : AC1 3) chain D residue 970 type sequence T description binding site for residue ZN D 1401 source : AC1 4) chain D residue 974 type sequence V description binding site for residue ZN D 1401 source : AC1 5) chain D residue 975 type sequence C description binding site for residue ZN D 1401 source : AC1 6) chain D residue 978 type sequence C description binding site for residue ZN D 1401 source : AC1 7) chain D residue 60 type sequence C description binding site for residue ZN D 1402 source : AC2 8) chain D residue 61 type sequence Y description binding site for residue ZN D 1402 source : AC2 9) chain D residue 62 type sequence C description binding site for residue ZN D 1402 source : AC2 10) chain D residue 63 type sequence G description binding site for residue ZN D 1402 source : AC2 11) chain D residue 64 type sequence K description binding site for residue ZN D 1402 source : AC2 12) chain D residue 78 type sequence C description binding site for residue ZN D 1402 source : AC2 13) chain D residue 535 type sequence D description binding site for residue MG D 1403 source : AC3 14) chain D residue 537 type sequence D description binding site for residue MG D 1403 source : AC3 15) chain D residue 539 type sequence D description binding site for residue MG D 1403 source : AC3 16) chain D residue 84 type sequence R description binding site for residue FI8 D 1404 source : AC4 17) chain D residue 86 type sequence K description binding site for residue FI8 D 1404 source : AC4 18) chain D residue 412 type sequence R description binding site for residue FI8 D 1404 source : AC4 19) chain D residue 975 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 20) chain D residue 978 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 21) chain D residue 62 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 22) chain D residue 75 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 23) chain D residue 78 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 24) chain D residue 535 type DNA_BIND sequence D description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 25) chain D residue 537 type DNA_BIND sequence D description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 26) chain D residue 539 type DNA_BIND sequence D description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 27) chain D residue 891 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 28) chain D residue 968 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1

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