eF-site ID 6c06-ABCDEFJ PDB Code 6c06 Chain A, B, C, D, E, F, J Title Mycobacterium tuberculosis RNAP Holo/RbpA/Fidaxomicin Classification transcription/antibiotic Compound DNA-directed RNA polymerase subunit alpha Source Mycobacterium tuberculosis (A0A045IP01_MYCTX) Sequence A:  MLISQRPTLSEDVLTDNRSQFVIEPLEPGFGYTLGNSLRR TLLSSIPGAAVTSIRIDGVLHEFTTVPGVKEDVTEIILNL KSLVVSSEEDEPVTMYLRKQGPGEVTAGDIVPPAGVTVHN PGMHIATLNDKGKLEVELVVERGRGYVPAVQNRASGAEIG RIPVDSIYSPVLKVTYKVDATRVEQRTDFDKLILDVETKN SISPRDALASAGKTLVELFGLARELN B:  MLISQRPTLSEDVLTDNRSQFVIEPLEPGFGYTLGNSLRR TLLSSIPGAAVTSIRIDGVLHEFTTVPGVKEDVTEIILNL KSLVVSSEEDEPVTMYLRKQGPGEVTAGDIVPPAGVTVHN PGMHIATLNDKGKLEVELVVERGRGYVPAVQNRASGAEIG RIPVDSIYSPVLKVTYKVDATRVEQRTDFDKLILDVETKN SISPRDALASAGKTLVELFGLARELNVEAEGIEIGPS C:  NSVPGAPNRVSFAKLREPLEVPGLLDVQTDSFEWLIGSPR WRESAAERGDVNPVGGLEEVLYELSPIEDFSGSMSLSFSD PRFDDVKAPVDECKDKDMTYAAPLFVTAEFINNNTGEIKS QTVFMGDFPMMTEKGTFIINGTERVVVSQLVRSPGVYFDE TIDKSTDKTLHSVKVIPSRGAWLEFDVDKRDTVGVRIDRK RRQPVTVLLKALGWTSEQIVERFGFSEIMRSTLEKDNTVG TDEALLDIYRKLRPGEPPTKESAQTLLENLFFKEKRYDLA RVGRYKVNKKLGLHVGEPITSSTLTEEDVVATIEYLVRLH EGQTTMTVPGGVEVPVETDDIDHFGNRRLRTVGELIQNQI RVGMSRMERVVRERMTTQDVEAITPQTLINIRPVVAAIKE FFGTSQLSQFMDQNNPLSGLTHKRRLSALGPGGLSRERAG LEVRDVHPSHYGRMCPIETPEGPNIGLIGSLSVYARVNPF GFIETPYRKVVDGVVSDEIVYLTADEEDRHVVAQANSPID ADGRFVEPRVLVRRKAGEVEYVPSSEVDYMDVSPRQMVSV ATAMIPFLEHDDANRALMGANMQRQAVPLVRSEAPLVGTG MELRAAIDAGDVVVAEESGVIEEVSADYITVMHDNGTRRT YRMRKFARSNHGTCANQCPIVDAGDRVEAGQVIADGPCTD DGEMALGKNLLVAIMPWEGHNYEDAIILSNRLVEEDVLTS IHIEEHEIDARDTKLGAEEITRDIPNISDEVLADLDERGI VRIGAEVRDGDILVGKVTPKGETELTPEERLLRAIFGEKA REVRDTSLKVPHGESGKVIGIRVFSREDEDELPAGVNELV RVYVAQKRKISDGDKLAGRHGNKGVIGKILPVEDMPFLAD GTPVDIILNTHGVPRRMNIGQILETHLGWCAHSGWKVDAA KGVPDWAARLPDELLEAQPNAIVSTPVFDGAQEAELQGLL SCTLPNRDGDVLVDADGKAMLFDGRSGEPFPYPVTVGYMY IMKLHHLVDDKIHARSTGPYSMITQQPLGGKAQFGGQRFG EMECWAMQAYGAAYTLQELLTIKSDDTVGRVKVYEAIVKG ENIPEPGIPESFKVLLKELQSLCLNVEVLSS D:  VNFFDELRIGLATAEDIRQWSYGEVKKPETINYRTLKPEK DGLFCEKIFGPTRDWECYCGKYKRVRFKGIICERCGVEVT RAKVRRERMGHIELAAPVTHIWYFKGVPSRLGYLLDLAPK DLEKIIYFAAYVITSVDEEMRHNELSTLEAEMAVERKAVE DQRDGELEARAQKLEADLAELEAEGAKADARRKVRDGGER EMRQIRDRAQRELDRLEDIWSTFTKLAPKQLIVDENLYRE LVDRYGEYFTGAMGAESIQKLIENFDIDAEAESLRDVIRN GKGQKKLRALKRLKVVAAFQQSGNSPMGMVLDAVPVIPPE LRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLIDLGAP EIIVNNEKRMLQESVDALFDNGRRGRPVTGPGNRPLKSLS DLLKGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCGL PKLMALELFKPFVMKRLVDLNHAQNIKSAKRMVERQRPQV WDVLEEVIAEHPVLLNRAPTLHRLGIQAFEPMLVEGKAIQ LHPLVCEAFNADFDGDQMAVHLPLSAEAQAEARILMLSSN NILSPASGRPLAMPRLDMVTGLYYLTTEVPGDTGEYQPAS GDHPETGVYSSPAEAIMAADRGVLSVRAKIKVRLTQLRPP VEIEAELFGHSGWQPGDAWMAETTLGRVMFNELLPLGYPF VNKQMHKKVQAAIINDLAERYPMIVVAQTVDKLKDAGFYW ATRSGVTVSMADVLVPPRKKEILDHYEERADKVEKQFQRG ALNHDERNEALVEIWKEATDEVGQALREHYPDDNPIITIV DSGATGNFTQTRTLAGMKGLVTNPKGEFIPRPVKSSFREG LTVLEYFINTHGARKGLADTALRTADSGYLTRRLVDVSQD VIVREHDCQTERGIVVELAERAPDGTLIRDPYIETSAYAR TLGTDAVDEAGNVIVERGQDLGDPEIDALLAAGITQVKVR SVLTCATSTGVCATCYGRSMATGKLVDIGEAVGIVAAQSI GEPGTQLTMITGGLPRVQELFEARVPRGKAPIADVTGRVR LEDGERFYKITIVPDDGGEEVVYDKISKRQRLRVFKERVL SDGDHVEVGQQLMEGSADPHEVLRVQGPREVQIHLVREVQ EVYRAQGVSIHDKHIEVIVRQMLRRVTIIDSGSTEFLPGS LIDRAEFEAENRRVVAEGGEPAAGRPVLMGITKASLATDS WLSAASFQETTRVLTDAAINCRSDKLNGLKENVIIGKLIP AGTGINRYRNIAVQPTEEARAAA E:  GGYDTPLGITNPPIDELLDRVSSKYALVIYAAKRARQIND YYNQLGEGILEYVGPLVEPGLQEKPLSIALREIHADLLEH TEG F:  FVWDEDESEALRQARKDAELTASADSVRAYLKQIGKVALL NAEEEVELAKRIEAGLYATQLMTELSERGEKLPAAQRRDM MWICRDGDRAKNHLLEANLRLVVSLAKRYTGRGMAFLDLI QEGNLGLIRAVEKFDYTKGYKFSTYATWWIRQAITRAMAD QARTIRIPVHMVEVINKLGRIQRELLQDLGREPTPEELAK EMDITPEKVLEIQQYAREPISLDQTIGDEGDSQLGDFIED SEAVVAVDAVSFTLLQDQLQSVLDTLSEREAGVVRLRFGL TDGQPRTLDEIGQVYGVTRERIRQIESKTMSKLRHPSRSQ VLRDYL J:  ADRVLRGSRLGAVSYETDRNHDLAPRQIARYRTDNGEEFE VPFADDAEIPGTWLCRNGMEGTLIEGDLPEPKKVKPPRTH WDMLLERRSIEELEELLKERLELIRSR Description Functional site 1) chain D residue 891 type sequence C description binding site for residue ZN D 1401 source : AC1 2) chain D residue 968 type sequence C description binding site for residue ZN D 1401 source : AC1 3) chain D residue 970 type sequence T description binding site for residue ZN D 1401 source : AC1 4) chain D residue 974 type sequence V description binding site for residue ZN D 1401 source : AC1 5) chain D residue 975 type sequence C description binding site for residue ZN D 1401 source : AC1 6) chain D residue 978 type sequence C description binding site for residue ZN D 1401 source : AC1 7) chain D residue 60 type sequence C description binding site for residue ZN D 1402 source : AC2 8) chain D residue 61 type sequence Y description binding site for residue ZN D 1402 source : AC2 9) chain D residue 62 type sequence C description binding site for residue ZN D 1402 source : AC2 10) chain D residue 63 type sequence G description binding site for residue ZN D 1402 source : AC2 11) chain D residue 64 type sequence K description binding site for residue ZN D 1402 source : AC2 12) chain D residue 78 type sequence C description binding site for residue ZN D 1402 source : AC2 13) chain D residue 535 type sequence D description binding site for residue MG D 1403 source : AC3 14) chain D residue 537 type sequence D description binding site for residue MG D 1403 source : AC3 15) chain D residue 539 type sequence D description binding site for residue MG D 1403 source : AC3 16) chain C residue 1051 type sequence M description binding site for residue FI8 D 1404 source : AC4 17) chain C residue 1052 type sequence I description binding site for residue FI8 D 1404 source : AC4 18) chain C residue 1053 type sequence T description binding site for residue FI8 D 1404 source : AC4 19) chain C residue 1054 type sequence Q description binding site for residue FI8 D 1404 source : AC4 20) chain C residue 1094 type sequence D description binding site for residue FI8 D 1404 source : AC4 21) chain C residue 1096 type sequence T description binding site for residue FI8 D 1404 source : AC4 22) chain C residue 1119 type sequence E description binding site for residue FI8 D 1404 source : AC4 23) chain C residue 1120 type sequence S description binding site for residue FI8 D 1404 source : AC4 24) chain D residue 84 type sequence R description binding site for residue FI8 D 1404 source : AC4 25) chain D residue 86 type sequence K description binding site for residue FI8 D 1404 source : AC4 26) chain D residue 412 type sequence R description binding site for residue FI8 D 1404 source : AC4 27) chain F residue 489-508 type DNA_BIND sequence LDEIGQVYGVTRERIRQIES description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 28) chain D residue 975 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 29) chain D residue 978 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 30) chain D residue 62 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 31) chain D residue 75 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 32) chain D residue 78 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 33) chain D residue 535 type DNA_BIND sequence D description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 34) chain D residue 537 type DNA_BIND sequence D description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 35) chain D residue 539 type DNA_BIND sequence D description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 36) chain D residue 891 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 37) chain D residue 968 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 38) chain C residue 882-894 type prosite sequence GDKLAGRHGNKGV description RNA_POL_BETA RNA polymerases beta chain signature. GdKLAGrHGNKGV source prosite : PS01166 39) chain F residue 319-332 type prosite sequence DLIQEGNLGLIRAV description SIGMA70_1 Sigma-70 factors family signature 1. DLIQeGnLGLIrAV source prosite : PS00715 40) chain F residue 488-514 type prosite sequence TLDEIGQVYGVTRERIRQIESKTMSKL description SIGMA70_2 Sigma-70 factors family signature 2. TldEIGqvygVTrerIrQIEsktMskL source prosite : PS00716 41) chain F residue 295-302 type prosite sequence LLEANLRL description CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. LLEANLRL source prosite : PS00867

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