eF-site ID 6c04-ABCDEFJ PDB Code 6c04 Chain A, B, C, D, E, F, J Title Mtb RNAP Holo/RbpA/double fork DNA -closed clamp Classification transcription/dna Compound DNA-directed RNA polymerase subunit alpha Source (6C04) Sequence A:  MLISQRPTLSEDVLTDNRSQFVIEPLEPGFGYTLGNSLRR TLLSSIPGAAVTSIRIDGVLHEFTTVPGVKEDVTEIILNL KSLVVSSEEDEPVTMYLRKQGPGEVTAGDIVPPAGVTVHN PGMHIATLNDKGKLEVELVVERGRGYVPAVQNRASGAEIG RIPVDSIYSPVLKVTYKVDATRVEQRTDFDKLILDVETKN SISPRDALASAGKTLVELFGLARELN B:  MLISQRPTLSEDVLTDNRSQFVIEPLEPGFGYTLGNSLRR TLLSSIPGAAVTSIRIDGVLHEFTTVPGVKEDVTEIILNL KSLVVSSEEDEPVTMYLRKQGPGEVTAGDIVPPAGVTVHN PGMHIATLNDKGKLEVELVVERGRGYVPAVQNRASGAEIG RIPVDSIYSPVLKVTYKVDATRVEQRTDFDKLILDVETKN SISPRDALASAGKTLVELFGLARELNVEAEGIEIGPS C:  NSVPGAPNRVSFAKLREPLEVPGLLDVQTDSFEWLIGSPR WRESAAERGDVNPVGGLEEVLYELSPIEDFSGSMSLSFSD PRFDDVKAPVDECKDKDMTYAAPLFVTAEFINNNTGEIKS QTVFMGDFPMMTEKGTFIINGTERVVVSQLVRSPGVYFDE TIDKSTDKTLHSVKVIPSRGAWLEFDVDKRDTVGVRIDRK RRQPVTVLLKALGWTSEQIVERFGFSEIMRSTLEKDNTVG TDEALLDIYRKLRPGEPPTKESAQTLLENLFFKEKRYDLA RVGRYKVNKKLGLHVGEPITSSTLTEEDVVATIEYLVRLH EGQTTMTVPGGVEVPVETDDIDHFGNRRLRTVGELIQNQI RVGMSRMERVVRERMTTQDVEAITPQTLINIRPVVAAIKE FFGTSQLSQFMDQNNPLSGLTHKRRLSALGPGGLSRERAG LEVRDVHPSHYGRMCPIETPEGPNIGLIGSLSVYARVNPF GFIETPYRKVVDGVVSDEIVYLTADEEDRHVVAQANSPID ADGRFVEPRVLVRRKAGEVEYVPSSEVDYMDVSPRQMVSV ATAMIPFLEHDDANRALMGANMQRQAVPLVRSEAPLVGTG MELRAAIDAGDVVVAEESGVIEEVSADYITVMHDNGTRRT YRMRKFARSNHGTCANQCPIVDAGDRVEAGQVIADGPCTD DGEMALGKNLLVAIMPWEGHNYEDAIILSNRLVEEDVLTS IHIEEHEIDARDTKLGAEEITRDIPNISDEVLADLDERGI VRIGAEVRDGDILVGKVTPKGETELTPEERLLRAIFGEKA REVRDTSLKVPHGESGKVIGIRVFSREDEDELPAGVNELV RVYVAQKRKISDGDKLAGRHGNKGVIGKILPVEDMPFLAD GTPVDIILNTHGVPRRMNIGQILETHLGWCAHSGWKVDAA KGVPDWAARLPDELLEAQPNAIVSTPVFDGAQEAELQGLL SCTLPNRDGDVLVDADGKAMLFDGRSGEPFPYPVTVGYMY IMKLHHLVDDKIHARSTGPYSMITQQPLGGKAQFGGQRFG EMECWAMQAYGAAYTLQELLTIKSDDTVGRVKVYEAIVKG ENIPEPGIPESFKVLLKELQSLCLNVEVLSS D:  GAMLDVNFFDELRIGLATAEDIRQWSYGEVKKPETINYRT LKPEKDGLFCEKIFGPTRDWECYCGKYKRVRFKGIICERC GVEVTRAKVRRERMGHIELAAPVTHIWYFKGVPSRLGYLL DLAPKDLEKIIYFAAYVITSVDEEMRHNELSTLEAEMAVE RKAVEDQRDGELEARAQKLEADLAELEAEGAKADARRKVR DGGEREMRQIRDRAQRELDRLEDIWSTFTKLAPKQLIVDE NLYRELVDRYGEYFTGAMGAESIQKLIENFDIDAEAESLR DVIRNGKGQKKLRALKRLKVVAAFQQSGNSPMGMVLDAVP VIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLI DLGAPEIIVNNEKRMLQESVDALFDNGRRGRPVTGPGNRP LKSLSDLLKGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKL HQCGLPKLMALELFKPFVMKRLVDLNHAQNIKSAKRMVER QRPQVWDVLEEVIAEHPVLLNRAPTLHRLGIQAFEPMLVE GKAIQLHPLVCEAFNADFDGDQMAVHLPLSAEAQAEARIL MLSSNNILSPASGRPLAMPRLDMVTGLYYLTTEVPGDTGE YQPASGDHPETGVYSSPAEAIMAADRGVLSVRAKIKVRLT QLRPPVEIEAELFGHSGWQPGDAWMAETTLGRVMFNELLP LGYPFVNKQMHKKVQAAIINDLAERYPMIVVAQTVDKLKD AGFYWATRSGVTVSMADVLVPPRKKEILDHYEERADKVEK QFQRGALNHDERNEALVEIWKEATDEVGQALREHYPDDNP IITIVDSGATGNFTQTRTLAGMKGLVTNPKGEFIPRPVKS SFREGLTVLEYFINTHGARKGLADTALRTADSGYLTRRLV DVSQDVIVREHDCQTERGIVVELAERAPDGTLIRDPYIET SAYARTLGTDAVDEAGNVIVERGQDLGDPEIDALLAAGIT QVKVRSVLTCATSTGVCATCYGRSMATGKLVDIGEAVGIV AAQSIGEPGTQLTMITGGLPRVQELFEARVPRGKAPIADV TGRVRLEDGERFYKITIVPDDGGEEVVYDKISKRQRLRVF KRVLSDGDHVEVGQQLMEGSADPHEVLRVQGPREVQIHLV REVQEVYRAQGVSIHDKHIEVIVRQMLRRVTIIDSGSTEF LPGSLIDRAEFEAENRRVVAEGGEPAAGRPVLMGITKASL ATDSWLSAASFQETTRVLTDAAINCRSDKLNGLKENVIIG KLIPAGTGINRYRNIAVQPTEEARAAA E:  GGYDTPLGITNPPIDELLDRVSSKYALVIYAAKRARQIND YYNQLGEGILEYVGPLVEPGLQEKPLSIALREIHADLLEH TEG F:  SEALRQARKDAELTASADSVRAYLKQIGKVALLNAEEEVE LAKRIEAGLYATQLMTELSERGEKLPAAQRRDMMWICRDG DRAKNHLLEANLRLVVSLAKRYTGRGMAFLDLIQEGNLGL IRAVEKFDYTKGYKFSTYATWWIRQAITRAMADQARTIRI PVHMVEVINKLGRIQRELLQDLGREPTPEELAKEMDITPE KVLEIQQYAREPISLDQTIGDEGDSQLGDFIEDSEAVVAV DAVSFTLLQDQLQSVLDTLSEREAGVVRLRFGLTDGQPRT LDEIGQVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYL J:  RVLRGSRLGAVSYETDRNHDLAPRQIARYRTDNGEEFEVP FADDAEIPGTWLCRNGMEGTLIEGDLPEPKKVKPPRTHWD MLLERRSIEELEELLKERLELIRSRRRG Description Functional site 1) chain D residue 891 type sequence C description binding site for residue ZN D 2000 source : AC1 2) chain D residue 968 type sequence C description binding site for residue ZN D 2000 source : AC1 3) chain D residue 975 type sequence C description binding site for residue ZN D 2000 source : AC1 4) chain D residue 978 type sequence C description binding site for residue ZN D 2000 source : AC1 5) chain D residue 60 type sequence C description binding site for residue ZN D 2001 source : AC2 6) chain D residue 62 type sequence C description binding site for residue ZN D 2001 source : AC2 7) chain D residue 75 type sequence C description binding site for residue ZN D 2001 source : AC2 8) chain D residue 78 type sequence C description binding site for residue ZN D 2001 source : AC2 9) chain D residue 535 type sequence D description binding site for residue MG D 2002 source : AC3 10) chain D residue 537 type sequence D description binding site for residue MG D 2002 source : AC3 11) chain D residue 539 type sequence D description binding site for residue MG D 2002 source : AC3 12) chain F residue 489-508 type DNA_BIND sequence LDEIGQVYGVTRERIRQIES description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 13) chain D residue 975 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 14) chain D residue 978 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 15) chain D residue 62 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 16) chain D residue 75 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 17) chain D residue 78 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 18) chain D residue 535 type DNA_BIND sequence D description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 19) chain D residue 537 type DNA_BIND sequence D description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 20) chain D residue 539 type DNA_BIND sequence D description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 21) chain D residue 891 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 22) chain D residue 968 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 23) chain C residue 882-894 type prosite sequence GDKLAGRHGNKGV description RNA_POL_BETA RNA polymerases beta chain signature. GdKLAGrHGNKGV source prosite : PS01166 24) chain F residue 319-332 type prosite sequence DLIQEGNLGLIRAV description SIGMA70_1 Sigma-70 factors family signature 1. DLIQeGnLGLIrAV source prosite : PS00715 25) chain F residue 488-514 type prosite sequence TLDEIGQVYGVTRERIRQIESKTMSKL description SIGMA70_2 Sigma-70 factors family signature 2. TldEIGqvygVTrerIrQIEsktMskL source prosite : PS00716 26) chain F residue 295-302 type prosite sequence LLEANLRL description CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. LLEANLRL source prosite : PS00867

Display surface Download Links