|
eF-site ID
|
6bx8-E |
PDB Code
|
6bx8 |
Chain
|
E |
|
click to enlarge
|
|
Title
|
Human Mesotrypsin (PRSS3) Complexed with Tissue Factor Pathway Inhibitor Variant (TFPI1-KD1-K15R-I17C-I34C) |
Classification
|
HYDROLASE |
Compound
|
Trypsin-3 |
Source
|
(TFPI1_HUMAN) |
|
Sequence
|
E: |
IVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVSAAH
CYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDT
LDNDIMLIKLSSPAVINARVSTISLPTAPPAAGTECLISG
WGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKITNSM
FCVGFLEGGKDSCQRDAGGPVVCNGQLQGVVSWGHGCAWK
NRPGVYTKVYNYVDWIKDTIAANS
|
|
Description
|
|
Functional site
|
|
1)
|
chain |
E |
residue |
20 |
type |
|
sequence |
Y
|
description |
binding site for residue SO4 F 101
|
source |
: AC3
|
|
2)
|
chain |
E |
residue |
21 |
type |
|
sequence |
T
|
description |
binding site for residue SO4 F 101
|
source |
: AC3
|
|
3)
|
chain |
E |
residue |
96 |
type |
|
sequence |
R
|
description |
binding site for residue SO4 F 101
|
source |
: AC3
|
|
4)
|
chain |
E |
residue |
57 |
type |
SITE |
sequence |
H
|
description |
Reactive bond
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
5)
|
chain |
E |
residue |
102 |
type |
SITE |
sequence |
D
|
description |
Reactive bond
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
6)
|
chain |
E |
residue |
195 |
type |
SITE |
sequence |
A
|
description |
Reactive bond
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
7)
|
chain |
E |
residue |
70 |
type |
BINDING |
sequence |
E
|
description |
BINDING => ECO:0000269|PubMed:11827488, ECO:0000269|PubMed:25301953, ECO:0000269|PubMed:27810896, ECO:0007744|PDB:1H4W, ECO:0007744|PDB:3L33, ECO:0007744|PDB:3L3T, ECO:0007744|PDB:3P92, ECO:0007744|PDB:3P95, ECO:0007744|PDB:4U30, ECO:0007744|PDB:4U32, ECO:0007744|PDB:5JBT, ECO:0007744|PDB:5TP0
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
8)
|
chain |
E |
residue |
72 |
type |
BINDING |
sequence |
N
|
description |
BINDING => ECO:0000269|PubMed:11827488, ECO:0000269|PubMed:25301953, ECO:0000269|PubMed:27810896, ECO:0007744|PDB:1H4W, ECO:0007744|PDB:3L33, ECO:0007744|PDB:3L3T, ECO:0007744|PDB:3P92, ECO:0007744|PDB:3P95, ECO:0007744|PDB:4U30, ECO:0007744|PDB:4U32, ECO:0007744|PDB:5JBT, ECO:0007744|PDB:5TP0
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
9)
|
chain |
E |
residue |
75 |
type |
BINDING |
sequence |
V
|
description |
BINDING => ECO:0000269|PubMed:11827488, ECO:0000269|PubMed:25301953, ECO:0000269|PubMed:27810896, ECO:0007744|PDB:1H4W, ECO:0007744|PDB:3L33, ECO:0007744|PDB:3L3T, ECO:0007744|PDB:3P92, ECO:0007744|PDB:3P95, ECO:0007744|PDB:4U30, ECO:0007744|PDB:4U32, ECO:0007744|PDB:5JBT, ECO:0007744|PDB:5TP0
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
10)
|
chain |
E |
residue |
77 |
type |
BINDING |
sequence |
E
|
description |
BINDING => ECO:0000269|PubMed:11827488, ECO:0000269|PubMed:25301953, ECO:0000269|PubMed:27810896, ECO:0007744|PDB:1H4W, ECO:0007744|PDB:3L33, ECO:0007744|PDB:3L3T, ECO:0007744|PDB:3P92, ECO:0007744|PDB:3P95, ECO:0007744|PDB:4U30, ECO:0007744|PDB:4U32, ECO:0007744|PDB:5JBT
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
11)
|
chain |
E |
residue |
80 |
type |
BINDING |
sequence |
E
|
description |
BINDING => ECO:0000269|PubMed:11827488, ECO:0000269|PubMed:25301953, ECO:0000269|PubMed:27810896, ECO:0007744|PDB:1H4W, ECO:0007744|PDB:3L33, ECO:0007744|PDB:3L3T, ECO:0007744|PDB:3P92, ECO:0007744|PDB:3P95, ECO:0007744|PDB:4U32, ECO:0007744|PDB:5JBT, ECO:0007744|PDB:5TP0
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
12)
|
chain |
E |
residue |
189 |
type |
SITE |
sequence |
D
|
description |
Required for specificity => ECO:0000250
|
source |
Swiss-Prot : SWS_FT_FI5
|
|
13)
|
chain |
E |
residue |
151 |
type |
MOD_RES |
sequence |
Y
|
description |
Sulfotyrosine => ECO:0000250
|
source |
Swiss-Prot : SWS_FT_FI6
|
|
|
|