eF-site ID 6bx8-E
PDB Code 6bx8
Chain E

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Title Human Mesotrypsin (PRSS3) Complexed with Tissue Factor Pathway Inhibitor Variant (TFPI1-KD1-K15R-I17C-I34C)
Classification HYDROLASE
Compound Trypsin-3
Source (TFPI1_HUMAN)
Sequence E:  IVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVSAAH
CYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDT
LDNDIMLIKLSSPAVINARVSTISLPTAPPAAGTECLISG
WGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKITNSM
FCVGFLEGGKDSCQRDAGGPVVCNGQLQGVVSWGHGCAWK
NRPGVYTKVYNYVDWIKDTIAANS
Description


Functional site

1) chain E
residue 20
type
sequence Y
description binding site for residue SO4 F 101
source : AC3

2) chain E
residue 21
type
sequence T
description binding site for residue SO4 F 101
source : AC3

3) chain E
residue 96
type
sequence R
description binding site for residue SO4 F 101
source : AC3

4) chain E
residue 57
type SITE
sequence H
description Reactive bond
source Swiss-Prot : SWS_FT_FI1

5) chain E
residue 102
type SITE
sequence D
description Reactive bond
source Swiss-Prot : SWS_FT_FI1

6) chain E
residue 195
type SITE
sequence A
description Reactive bond
source Swiss-Prot : SWS_FT_FI1

7) chain E
residue 70
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:11827488, ECO:0000269|PubMed:25301953, ECO:0000269|PubMed:27810896, ECO:0007744|PDB:1H4W, ECO:0007744|PDB:3L33, ECO:0007744|PDB:3L3T, ECO:0007744|PDB:3P92, ECO:0007744|PDB:3P95, ECO:0007744|PDB:4U30, ECO:0007744|PDB:4U32, ECO:0007744|PDB:5JBT, ECO:0007744|PDB:5TP0
source Swiss-Prot : SWS_FT_FI2

8) chain E
residue 72
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:11827488, ECO:0000269|PubMed:25301953, ECO:0000269|PubMed:27810896, ECO:0007744|PDB:1H4W, ECO:0007744|PDB:3L33, ECO:0007744|PDB:3L3T, ECO:0007744|PDB:3P92, ECO:0007744|PDB:3P95, ECO:0007744|PDB:4U30, ECO:0007744|PDB:4U32, ECO:0007744|PDB:5JBT, ECO:0007744|PDB:5TP0
source Swiss-Prot : SWS_FT_FI2

9) chain E
residue 75
type BINDING
sequence V
description BINDING => ECO:0000269|PubMed:11827488, ECO:0000269|PubMed:25301953, ECO:0000269|PubMed:27810896, ECO:0007744|PDB:1H4W, ECO:0007744|PDB:3L33, ECO:0007744|PDB:3L3T, ECO:0007744|PDB:3P92, ECO:0007744|PDB:3P95, ECO:0007744|PDB:4U30, ECO:0007744|PDB:4U32, ECO:0007744|PDB:5JBT, ECO:0007744|PDB:5TP0
source Swiss-Prot : SWS_FT_FI2

10) chain E
residue 77
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:11827488, ECO:0000269|PubMed:25301953, ECO:0000269|PubMed:27810896, ECO:0007744|PDB:1H4W, ECO:0007744|PDB:3L33, ECO:0007744|PDB:3L3T, ECO:0007744|PDB:3P92, ECO:0007744|PDB:3P95, ECO:0007744|PDB:4U30, ECO:0007744|PDB:4U32, ECO:0007744|PDB:5JBT
source Swiss-Prot : SWS_FT_FI3

11) chain E
residue 80
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:11827488, ECO:0000269|PubMed:25301953, ECO:0000269|PubMed:27810896, ECO:0007744|PDB:1H4W, ECO:0007744|PDB:3L33, ECO:0007744|PDB:3L3T, ECO:0007744|PDB:3P92, ECO:0007744|PDB:3P95, ECO:0007744|PDB:4U32, ECO:0007744|PDB:5JBT, ECO:0007744|PDB:5TP0
source Swiss-Prot : SWS_FT_FI4

12) chain E
residue 189
type SITE
sequence D
description Required for specificity => ECO:0000250
source Swiss-Prot : SWS_FT_FI5

13) chain E
residue 151
type MOD_RES
sequence Y
description Sulfotyrosine => ECO:0000250
source Swiss-Prot : SWS_FT_FI6


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