|
|
eF-site ID
|
6bx8-A |
|
PDB Code
|
6bx8 |
|
Chain
|
A |
|
click to enlarge
|
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Title
|
Human Mesotrypsin (PRSS3) Complexed with Tissue Factor Pathway Inhibitor Variant (TFPI1-KD1-K15R-I17C-I34C) |
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Classification
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HYDROLASE |
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Compound
|
Trypsin-3 |
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Source
|
(TFPI1_HUMAN) |
|
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Sequence
|
A: |
IVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVSAAH
CYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDT
LDNDIMLIKLSSPAVINARVSTISLPTAPPAAGTECLISG
WGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKITNSM
FCVGFLEGGKDSCQRDAGGPVVCNGQLQGVVSWGHGCAWK
NRPGVYTKVYNYVDWIKDTIAANS
|
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Description
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
20 |
| type |
|
| sequence |
Y
|
| description |
binding site for residue SO4 B 101
|
| source |
: AC1
|
|
|
2)
|
chain |
A |
| residue |
21 |
| type |
|
| sequence |
T
|
| description |
binding site for residue SO4 B 101
|
| source |
: AC1
|
|
|
3)
|
chain |
A |
| residue |
70 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000269|PubMed:11827488, ECO:0000269|PubMed:25301953, ECO:0000269|PubMed:27810896, ECO:0007744|PDB:1H4W, ECO:0007744|PDB:3L33, ECO:0007744|PDB:3L3T, ECO:0007744|PDB:3P92, ECO:0007744|PDB:3P95, ECO:0007744|PDB:4U30, ECO:0007744|PDB:4U32, ECO:0007744|PDB:5JBT, ECO:0007744|PDB:5TP0
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
4)
|
chain |
A |
| residue |
72 |
| type |
BINDING |
| sequence |
N
|
| description |
BINDING => ECO:0000269|PubMed:11827488, ECO:0000269|PubMed:25301953, ECO:0000269|PubMed:27810896, ECO:0007744|PDB:1H4W, ECO:0007744|PDB:3L33, ECO:0007744|PDB:3L3T, ECO:0007744|PDB:3P92, ECO:0007744|PDB:3P95, ECO:0007744|PDB:4U30, ECO:0007744|PDB:4U32, ECO:0007744|PDB:5JBT, ECO:0007744|PDB:5TP0
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
5)
|
chain |
A |
| residue |
75 |
| type |
BINDING |
| sequence |
V
|
| description |
BINDING => ECO:0000269|PubMed:11827488, ECO:0000269|PubMed:25301953, ECO:0000269|PubMed:27810896, ECO:0007744|PDB:1H4W, ECO:0007744|PDB:3L33, ECO:0007744|PDB:3L3T, ECO:0007744|PDB:3P92, ECO:0007744|PDB:3P95, ECO:0007744|PDB:4U30, ECO:0007744|PDB:4U32, ECO:0007744|PDB:5JBT, ECO:0007744|PDB:5TP0
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
6)
|
chain |
A |
| residue |
189 |
| type |
SITE |
| sequence |
D
|
| description |
Required for specificity => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
7)
|
chain |
A |
| residue |
151 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
Sulfotyrosine => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
8)
|
chain |
A |
| residue |
77 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000269|PubMed:11827488, ECO:0000269|PubMed:25301953, ECO:0000269|PubMed:27810896, ECO:0007744|PDB:1H4W, ECO:0007744|PDB:3L33, ECO:0007744|PDB:3L3T, ECO:0007744|PDB:3P92, ECO:0007744|PDB:3P95, ECO:0007744|PDB:4U30, ECO:0007744|PDB:4U32, ECO:0007744|PDB:5JBT
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
9)
|
chain |
A |
| residue |
80 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000269|PubMed:11827488, ECO:0000269|PubMed:25301953, ECO:0000269|PubMed:27810896, ECO:0007744|PDB:1H4W, ECO:0007744|PDB:3L33, ECO:0007744|PDB:3L3T, ECO:0007744|PDB:3P92, ECO:0007744|PDB:3P95, ECO:0007744|PDB:4U32, ECO:0007744|PDB:5JBT, ECO:0007744|PDB:5TP0
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
10)
|
chain |
A |
| residue |
53-58 |
| type |
prosite |
| sequence |
VSAAHC
|
| description |
TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC
|
| source |
prosite : PS00134
|
|
|
|