eF-site ID 6bw6-C PDB Code 6bw6 Chain C click to enlarge Title Human GPT (DPAGT1) H129 variant in complex with tunicamycin Classification TRANSFERASE/ANTIBIOTIC Compound UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase Source (GPT_HUMAN) Sequence C:  PMPLLINLIVSLLGFVATVTLIPAFRGHFIAARLCGQDLN KTSRQQIPESQGVISGAVFLIILFCFIPFPFLNCAFPHHE FVALIGALLAICCMIFLGFADDVLNLRWRHKLLLHTAASL PLLMVYFTNFGNTTIVHLDLGILYYVYMGLLAVFCTNAIN ILAGINGLEAGQSLVISASIIVFNLVELEGDCRDDHVFSL YFMIPFFFTTLGLLYHNWYPSRVFVGDTFCYFAGMTFAVV GILGHFSKTMLLFFMPQVFNFLYSLPQLLHIIPCPRHRIP RLNIKTGKLEMSYSKFKTKSLSFLGTFILKVAESLQLVTV HQCNNMTLINLLLKVLGPIHERNLTLLLLLLQILGSAITF SIRYQ Description Functional site 1) chain C residue 44 type sequence Q description binding site for residue TUM C 501 source : AC5 2) chain C residue 45 type sequence D description binding site for residue TUM C 501 source : AC5 3) chain C residue 46 type sequence L description binding site for residue TUM C 501 source : AC5 4) chain C residue 122 type sequence W description binding site for residue TUM C 501 source : AC5 5) chain C residue 185 type sequence N description binding site for residue TUM C 501 source : AC5 6) chain C residue 186 type sequence I description binding site for residue TUM C 501 source : AC5 7) chain C residue 188 type sequence A description binding site for residue TUM C 501 source : AC5 8) chain C residue 189 type sequence G description binding site for residue TUM C 501 source : AC5 9) chain C residue 190 type sequence I description binding site for residue TUM C 501 source : AC5 10) chain C residue 191 type sequence N description binding site for residue TUM C 501 source : AC5 11) chain C residue 249 type sequence F description binding site for residue TUM C 501 source : AC5 12) chain C residue 252 type sequence D description binding site for residue TUM C 501 source : AC5 13) chain C residue 293 type sequence L description binding site for residue TUM C 501 source : AC5 14) chain C residue 301 type sequence R description binding site for residue TUM C 501 source : AC5 15) chain C residue 302 type sequence H description binding site for residue TUM C 501 source : AC5 16) chain C residue 303 type sequence R description binding site for residue TUM C 501 source : AC5 17) chain C residue 304 type sequence I description binding site for residue TUM C 501 source : AC5 18) chain C residue 107 type sequence C description binding site for residue PGW C 502 source : AC6 19) chain C residue 110 type sequence F description binding site for residue PGW C 502 source : AC6 20) chain C residue 114 type sequence A description binding site for residue PGW C 502 source : AC6 21) chain C residue 118 type sequence L description binding site for residue PGW C 502 source : AC6 22) chain C residue 124 type sequence H description binding site for residue PGW C 502 source : AC6 23) chain C residue 28 type sequence L description binding site for residue PGW C 503 source : AC7 24) chain C residue 31 type sequence A description binding site for residue PGW C 503 source : AC7 25) chain C residue 32 type sequence F description binding site for residue PGW C 503 source : AC7 26) chain C residue 35 type sequence H description binding site for residue PGW C 503 source : AC7 27) chain C residue 68 type sequence I description binding site for residue PGW C 503 source : AC7 28) chain C residue 71 type sequence F description binding site for residue PGW C 503 source : AC7 29) chain C residue 56 type BINDING sequence E description BINDING => ECO:0000269|PubMed:30388443 source Swiss-Prot : SWS_FT_FI13 30) chain C residue 191 type BINDING sequence N description BINDING => ECO:0000269|PubMed:30388443 source Swiss-Prot : SWS_FT_FI13 31) chain C residue 301 type BINDING sequence R description BINDING => ECO:0000269|PubMed:30388443 source Swiss-Prot : SWS_FT_FI13 32) chain C residue 44 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:30388443 source Swiss-Prot : SWS_FT_FI13 33) chain C residue 46 type BINDING sequence L description BINDING => ECO:0000269|PubMed:29459785, ECO:0007744|PDB:6BW5, ECO:0007744|PDB:6BW6 source Swiss-Prot : SWS_FT_FI14 34) chain C residue 303 type BINDING sequence R description BINDING => ECO:0000269|PubMed:29459785, ECO:0007744|PDB:6BW5, ECO:0007744|PDB:6BW6 source Swiss-Prot : SWS_FT_FI14 35) chain C residue 79-91 type TOPO_DOM sequence LNCAFP description Lumenal => ECO:0000269|PubMed:29459785 source Swiss-Prot : SWS_FT_FI1 36) chain C residue 144-166 type TOPO_DOM sequence FGNTTIVHLDLG description Lumenal => ECO:0000269|PubMed:29459785 source Swiss-Prot : SWS_FT_FI1 37) chain C residue 214-218 type TOPO_DOM sequence EGDCR description Lumenal => ECO:0000269|PubMed:29459785 source Swiss-Prot : SWS_FT_FI1 38) chain C residue 270-271 type TOPO_DOM sequence HF description Lumenal => ECO:0000269|PubMed:29459785 source Swiss-Prot : SWS_FT_FI1 39) chain C residue 251-269 type TRANSMEM sequence GDTFCYFAGMTFAVVGILG description Helical; Name=Helix 8 => ECO:0000269|PubMed:29459785 source Swiss-Prot : SWS_FT_FI10 40) chain C residue 272-293 type TRANSMEM sequence SKTMLLFFMPQVFNFLYSLPQL description Helical; Name=Helix 9 => ECO:0000269|PubMed:29459785 source Swiss-Prot : SWS_FT_FI11 41) chain C residue 376-400 type TRANSMEM sequence ERNLTLLLLLLQILGSAITFSIRYQ description Helical; Name=Helix 10 => ECO:0000269|PubMed:29459785 source Swiss-Prot : SWS_FT_FI12 42) chain C residue 119 type BINDING sequence N description BINDING => ECO:0000269|PubMed:29459785, ECO:0007744|PDB:6BW5 source Swiss-Prot : SWS_FT_FI15 43) chain C residue 252 type BINDING sequence D description BINDING => ECO:0000269|PubMed:29459785, ECO:0007744|PDB:6BW5 source Swiss-Prot : SWS_FT_FI15 44) chain C residue 125 type BINDING sequence K description BINDING => ECO:0000305|PubMed:30388443 source Swiss-Prot : SWS_FT_FI16 45) chain C residue 178 type BINDING sequence V description BINDING => ECO:0000305|PubMed:30388443 source Swiss-Prot : SWS_FT_FI16 46) chain C residue 59-78 type TRANSMEM sequence GVISGAVFLIILFCFIPFPF description Helical; Name=Helix 2 => ECO:0000269|PubMed:29459785 source Swiss-Prot : SWS_FT_FI4 47) chain C residue 146 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI18 48) chain C residue 11-38 type TRANSMEM sequence LLINLIVSLLGFVATVTLIPAFRGHFIA description Helical; Name=Helix 1 => ECO:0000269|PubMed:29459785 source Swiss-Prot : SWS_FT_FI2 49) chain C residue 39-58 type TOPO_DOM sequence ARLCGQDLNKTSRQQIPESQ description Cytoplasmic => ECO:0000269|PubMed:29459785 source Swiss-Prot : SWS_FT_FI3 50) chain C residue 119-121 type TOPO_DOM sequence NLR description Cytoplasmic => ECO:0000269|PubMed:29459785 source Swiss-Prot : SWS_FT_FI3 51) chain C residue 187-192 type TOPO_DOM sequence LAGING description Cytoplasmic => ECO:0000269|PubMed:29459785 source Swiss-Prot : SWS_FT_FI3 52) chain C residue 243-250 type TOPO_DOM sequence WYPSRVFV description Cytoplasmic => ECO:0000269|PubMed:29459785 source Swiss-Prot : SWS_FT_FI3 53) chain C residue 294-375 type TOPO_DOM sequence LHIIPCPRHRIPRLNIKTGKLEMSYSKFKTKSLSFLGTFI LKVAESLQLVTVHQCNNMTLINLLLKVLGPIH description Cytoplasmic => ECO:0000269|PubMed:29459785 source Swiss-Prot : SWS_FT_FI3 54) chain C residue 92-118 type TRANSMEM sequence HHEFVALIGALLAICCMIFLGFADDVL description Helical; Name=Helix 3 => ECO:0000269|PubMed:29459785 source Swiss-Prot : SWS_FT_FI5 55) chain C residue 122-143 type TRANSMEM sequence WRHKLLLHTAASLPLLMVYFTN description Helical; Name=Helix 4 => ECO:0000269|PubMed:29459785 source Swiss-Prot : SWS_FT_FI6 56) chain C residue 167-186 type TRANSMEM sequence ILYYVYMGLLAVFCTNAINI description Helical; Name=Helix 5 => ECO:0000269|PubMed:29459785 source Swiss-Prot : SWS_FT_FI7 57) chain C residue 193-213 type TRANSMEM sequence LEAGQSLVISASIIVFNLVEL description Helical; Name=Helix 6 => ECO:0000269|PubMed:29459785 source Swiss-Prot : SWS_FT_FI8 58) chain C residue 219-242 type TRANSMEM sequence DDHVFSLYFMIPFFFTTLGLLYHN description Helical; Name=Helix 7 => ECO:0000269|PubMed:29459785 source Swiss-Prot : SWS_FT_FI9 59) chain C residue 185 type BINDING sequence N description BINDING => ECO:0000269|PubMed:29459785, ECO:0007744|PDB:6BW6 source Swiss-Prot : SWS_FT_FI17

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