eF-site ID 6bw5-B
PDB Code 6bw5
Chain B

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Title Human GPT (DPAGT1) in complex with tunicamycin
Classification TRANSFERASE/ANTIBIOTIC
Compound UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
Source (GPT_HUMAN)
Sequence B:  MPLLINLIVSLLGFVATVTLIPAFRGHFIAARLCGQDLNK
TSRQQIPESQGVISGAVFLIILFCFIPFPFLNCAFPHHEF
VALIGALLAICCMIFLGFADDVLNLRWRHKLLLPTAASLP
LLMVYFTNFGNTTIVVHLDLGILYYVYMGLLAVFCTNAIN
ILAGINGLEAGQSLVISASIIVFNLVELEGDCRDDHVFSL
YFMIPFFFTTLGLLYHNWYPSRVFVGDTFCYFAGMTFAVV
GILGHFSKTMLLFFMPQVFNFLYSLPQLLHIIPCPRHRIP
RLNIKTGKLEMSYSKFKTKFLGTFILKVAESLQLVTVHQE
DGEFTECNNMTLINLLLKVLGPIHERNLTLLLLLLQILGS
AITFSIRYQ
Description


Functional site

1) chain B
residue 64
type
sequence A
description binding site for residue PGW A 502
source : AC2

2) chain B
residue 68
type
sequence I
description binding site for residue PGW A 502
source : AC2

3) chain B
residue 71
type
sequence F
description binding site for residue PGW A 502
source : AC2

4) chain B
residue 44
type
sequence Q
description binding site for residue TUM B 501
source : AC3

5) chain B
residue 45
type
sequence D
description binding site for residue TUM B 501
source : AC3

6) chain B
residue 46
type
sequence L
description binding site for residue TUM B 501
source : AC3

7) chain B
residue 119
type
sequence N
description binding site for residue TUM B 501
source : AC3

8) chain B
residue 122
type
sequence W
description binding site for residue TUM B 501
source : AC3

9) chain B
residue 125
type
sequence K
description binding site for residue TUM B 501
source : AC3

10) chain B
residue 126
type
sequence L
description binding site for residue TUM B 501
source : AC3

11) chain B
residue 179
type
sequence F
description binding site for residue TUM B 501
source : AC3

12) chain B
residue 185
type
sequence N
description binding site for residue TUM B 501
source : AC3

13) chain B
residue 186
type
sequence I
description binding site for residue TUM B 501
source : AC3

14) chain B
residue 188
type
sequence A
description binding site for residue TUM B 501
source : AC3

15) chain B
residue 189
type
sequence G
description binding site for residue TUM B 501
source : AC3

16) chain B
residue 190
type
sequence I
description binding site for residue TUM B 501
source : AC3

17) chain B
residue 191
type
sequence N
description binding site for residue TUM B 501
source : AC3

18) chain B
residue 249
type
sequence F
description binding site for residue TUM B 501
source : AC3

19) chain B
residue 252
type
sequence D
description binding site for residue TUM B 501
source : AC3

20) chain B
residue 286
type
sequence F
description binding site for residue TUM B 501
source : AC3

21) chain B
residue 293
type
sequence L
description binding site for residue TUM B 501
source : AC3

22) chain B
residue 301
type
sequence R
description binding site for residue TUM B 501
source : AC3

23) chain B
residue 303
type
sequence R
description binding site for residue TUM B 501
source : AC3

24) chain B
residue 304
type
sequence I
description binding site for residue TUM B 501
source : AC3

25) chain B
residue 110
type
sequence F
description binding site for residue PGW B 502
source : AC4

26) chain B
residue 114
type
sequence A
description binding site for residue PGW B 502
source : AC4

27) chain B
residue 124
type
sequence H
description binding site for residue PGW B 502
source : AC4

28) chain B
residue 185
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:29459785, ECO:0007744|PDB:6BW6
source Swiss-Prot : SWS_FT_FI17

29) chain B
residue 214-218
type TOPO_DOM
sequence EGDCR
description Lumenal => ECO:0000269|PubMed:29459785
source Swiss-Prot : SWS_FT_FI1

30) chain B
residue 270-271
type TOPO_DOM
sequence HF
description Lumenal => ECO:0000269|PubMed:29459785
source Swiss-Prot : SWS_FT_FI1

31) chain B
residue 79-91
type TOPO_DOM
sequence LNCAFP
description Lumenal => ECO:0000269|PubMed:29459785
source Swiss-Prot : SWS_FT_FI1

32) chain B
residue 144-166
type TOPO_DOM
sequence FGNTTIVVHLDLG
description Lumenal => ECO:0000269|PubMed:29459785
source Swiss-Prot : SWS_FT_FI1

33) chain B
residue 251-269
type TRANSMEM
sequence GDTFCYFAGMTFAVVGILG
description Helical; Name=Helix 8 => ECO:0000269|PubMed:29459785
source Swiss-Prot : SWS_FT_FI10

34) chain B
residue 272-293
type TRANSMEM
sequence SKTMLLFFMPQVFNFLYSLPQL
description Helical; Name=Helix 9 => ECO:0000269|PubMed:29459785
source Swiss-Prot : SWS_FT_FI11

35) chain B
residue 376-400
type TRANSMEM
sequence ERNLTLLLLLLQILGSAITFSIRYQ
description Helical; Name=Helix 10 => ECO:0000269|PubMed:29459785
source Swiss-Prot : SWS_FT_FI12

36) chain B
residue 146
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI18

37) chain B
residue 11-38
type TRANSMEM
sequence LLINLIVSLLGFVATVTLIPAFRGHFIA
description Helical; Name=Helix 1 => ECO:0000269|PubMed:29459785
source Swiss-Prot : SWS_FT_FI2

38) chain B
residue 46
type BINDING
sequence L
description BINDING => ECO:0000269|PubMed:29459785, ECO:0007744|PDB:6BW5, ECO:0007744|PDB:6BW6
source Swiss-Prot : SWS_FT_FI14

39) chain B
residue 303
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:29459785, ECO:0007744|PDB:6BW5, ECO:0007744|PDB:6BW6
source Swiss-Prot : SWS_FT_FI14

40) chain B
residue 125
type BINDING
sequence K
description BINDING => ECO:0000305|PubMed:30388443
source Swiss-Prot : SWS_FT_FI16

41) chain B
residue 178
type BINDING
sequence V
description BINDING => ECO:0000305|PubMed:30388443
source Swiss-Prot : SWS_FT_FI16

42) chain B
residue 294-375
type TOPO_DOM
sequence LHIIPCPRHRIPRLNIKTGKLEMSYSKFKTKFLGTFILKV
AESLQLVTVHQEDGEFTECNNMTLINLLLKVLGPIH
description Cytoplasmic => ECO:0000269|PubMed:29459785
source Swiss-Prot : SWS_FT_FI3

43) chain B
residue 39-58
type TOPO_DOM
sequence ARLCGQDLNKTSRQQIPESQ
description Cytoplasmic => ECO:0000269|PubMed:29459785
source Swiss-Prot : SWS_FT_FI3

44) chain B
residue 119-121
type TOPO_DOM
sequence NLR
description Cytoplasmic => ECO:0000269|PubMed:29459785
source Swiss-Prot : SWS_FT_FI3

45) chain B
residue 187-192
type TOPO_DOM
sequence LAGING
description Cytoplasmic => ECO:0000269|PubMed:29459785
source Swiss-Prot : SWS_FT_FI3

46) chain B
residue 243-250
type TOPO_DOM
sequence WYPSRVFV
description Cytoplasmic => ECO:0000269|PubMed:29459785
source Swiss-Prot : SWS_FT_FI3

47) chain B
residue 59-78
type TRANSMEM
sequence GVISGAVFLIILFCFIPFPF
description Helical; Name=Helix 2 => ECO:0000269|PubMed:29459785
source Swiss-Prot : SWS_FT_FI4

48) chain B
residue 92-118
type TRANSMEM
sequence HHEFVALIGALLAICCMIFLGFADDVL
description Helical; Name=Helix 3 => ECO:0000269|PubMed:29459785
source Swiss-Prot : SWS_FT_FI5

49) chain B
residue 122-143
type TRANSMEM
sequence WRHKLLLPTAASLPLLMVYFTN
description Helical; Name=Helix 4 => ECO:0000269|PubMed:29459785
source Swiss-Prot : SWS_FT_FI6

50) chain B
residue 167-186
type TRANSMEM
sequence ILYYVYMGLLAVFCTNAINI
description Helical; Name=Helix 5 => ECO:0000269|PubMed:29459785
source Swiss-Prot : SWS_FT_FI7

51) chain B
residue 193-213
type TRANSMEM
sequence LEAGQSLVISASIIVFNLVEL
description Helical; Name=Helix 6 => ECO:0000269|PubMed:29459785
source Swiss-Prot : SWS_FT_FI8

52) chain B
residue 219-242
type TRANSMEM
sequence DDHVFSLYFMIPFFFTTLGLLYHN
description Helical; Name=Helix 7 => ECO:0000269|PubMed:29459785
source Swiss-Prot : SWS_FT_FI9

53) chain B
residue 44
type BINDING
sequence Q
description BINDING => ECO:0000269|PubMed:30388443
source Swiss-Prot : SWS_FT_FI13

54) chain B
residue 56
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:30388443
source Swiss-Prot : SWS_FT_FI13

55) chain B
residue 191
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:30388443
source Swiss-Prot : SWS_FT_FI13

56) chain B
residue 301
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:30388443
source Swiss-Prot : SWS_FT_FI13

57) chain B
residue 119
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:29459785, ECO:0007744|PDB:6BW5
source Swiss-Prot : SWS_FT_FI15

58) chain B
residue 252
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:29459785, ECO:0007744|PDB:6BW5
source Swiss-Prot : SWS_FT_FI15


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