eF-site ID 6bvk-B PDB Code 6bvk Chain B click to enlarge Title Ras:SOS:Ras in complex with a small molecule activator Classification SIGNALING PROTEIN Compound GTPase HRas Source (RASH_HUMAN) Sequence B:  GQMRLPSADVYRFAEPDSEENIIFEEGIPIIKAGTVIKLI ERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEI PEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVL NVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWV ESITKIIQRKKIANITFQSSPPTVEWHISRPGHIETFDLL TLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEIN SPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIE ILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQ KKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNI LKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQ PYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIE PRNPKPLPRFPKKYSYPLKSPGVRPSNPR Description (1)  GTPase HRas, Son of sevenless homolog 1 Functional site 1) chain B residue 878 type sequence M description binding site for residue EAV B 2001 source : AC3 2) chain B residue 879 type sequence N description binding site for residue EAV B 2001 source : AC3 3) chain B residue 884 type sequence Y description binding site for residue EAV B 2001 source : AC3 4) chain B residue 890 type sequence F description binding site for residue EAV B 2001 source : AC3 5) chain B residue 898 type sequence K description binding site for residue EAV B 2001 source : AC3 6) chain B residue 902 type sequence E description binding site for residue EAV B 2001 source : AC3 7) chain B residue 566 type sequence Q description binding site for residue FMT B 2002 source : AC4 8) chain B residue 567 type sequence M description binding site for residue FMT B 2002 source : AC4 9) chain B residue 616 type sequence H description binding site for residue FMT B 2002 source : AC4 10) chain B residue 617 type sequence M description binding site for residue FMT B 2002 source : AC4 11) chain B residue 767 type sequence R description binding site for residue FMT B 2003 source : AC5 12) chain B residue 768 type sequence P description binding site for residue FMT B 2003 source : AC5 13) chain B residue 619 type sequence A description binding site for residue FMT B 2004 source : AC6 14) chain B residue 688 type sequence R description binding site for residue FMT B 2004 source : AC6 15) chain B residue 615 type sequence Y description binding site for residue FMT B 2005 source : AC7 16) chain B residue 616 type sequence H description binding site for residue FMT B 2005 source : AC7 17) chain B residue 647 type sequence R description binding site for residue FMT B 2005 source : AC7 18) chain B residue 681 type sequence Y description binding site for residue FMT B 2005 source : AC7 19) chain B residue 1031 type sequence Y description binding site for residue FMT B 2006 source : AC8 20) chain B residue 793 type sequence S description binding site for residue GOL B 2007 source : AC9 21) chain B residue 794 type sequence D description binding site for residue GOL B 2007 source : AC9 22) chain B residue 978 type sequence P description binding site for residue GOL B 2007 source : AC9 23) chain B residue 979 type sequence Y description binding site for residue GOL B 2007 source : AC9 24) chain B residue 786 type sequence R description binding site for residue GOL B 2008 source : AD1 25) chain B residue 864 type sequence E description binding site for residue GOL B 2008 source : AD1 26) chain B residue 1040 type sequence V description binding site for residue GOL B 2008 source : AD1 27) chain B residue 938 type sequence L description binding site for residue FMT C 201 source : AD2 28) chain B residue 927-960 type prosite sequence VPFFGIYLTNILKTEEGNPEVLKRHGKELINFSK description RASGEF Ras Guanine-nucleotide exchange factors domain signature. VPFfGiyLtNIlkteegnpevlkrhgkel.................INFsK source prosite : PS00720

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