eF-site ID 6bvj-ABC PDB Code 6bvj Chain A, B, C click to enlarge Title Ras:SOS:Ras in complex with a small molecule activator Classification SIGNALING PROTEIN Compound GTPase HRas Source (RASH_HUMAN) Sequence A:  MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSY RKQVVIDGETXLLDILDTAGQEEYSAMRDQYMRTGEGFLC VFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL AARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLV REIRQH B:  GQMRLPSADVYRFAEPDSEENIIFEEGIPIIKAGTVIKLI ERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEI PEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVL NVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWV ESITKIIQRKKIANITFQSSPPTVEWHISRPGHIETFDLL TLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEIN SPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIE ILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQ KKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNI LKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQ PYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIE PRNPKPLPRFPKKYSYPLKSPGVRPSNPR C:  GMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDS YRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFL CVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCD LAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTL VREIRQH Description Functional site 1) chain A residue 12 type sequence G description binding site for residue GNP A 201 source : AC1 2) chain A residue 13 type sequence G description binding site for residue GNP A 201 source : AC1 3) chain A residue 14 type sequence V description binding site for residue GNP A 201 source : AC1 4) chain A residue 15 type sequence G description binding site for residue GNP A 201 source : AC1 5) chain A residue 16 type sequence K description binding site for residue GNP A 201 source : AC1 6) chain A residue 17 type sequence S description binding site for residue GNP A 201 source : AC1 7) chain A residue 18 type sequence A description binding site for residue GNP A 201 source : AC1 8) chain A residue 28 type sequence F description binding site for residue GNP A 201 source : AC1 9) chain A residue 29 type sequence V description binding site for residue GNP A 201 source : AC1 10) chain A residue 30 type sequence D description binding site for residue GNP A 201 source : AC1 11) chain A residue 31 type sequence E description binding site for residue GNP A 201 source : AC1 12) chain A residue 32 type sequence Y description binding site for residue GNP A 201 source : AC1 13) chain A residue 34 type sequence P description binding site for residue GNP A 201 source : AC1 14) chain A residue 35 type sequence T description binding site for residue GNP A 201 source : AC1 15) chain A residue 60 type sequence G description binding site for residue GNP A 201 source : AC1 16) chain A residue 61 type sequence Q description binding site for residue GNP A 201 source : AC1 17) chain A residue 116 type sequence N description binding site for residue GNP A 201 source : AC1 18) chain A residue 117 type sequence K description binding site for residue GNP A 201 source : AC1 19) chain A residue 119 type sequence D description binding site for residue GNP A 201 source : AC1 20) chain A residue 120 type sequence L description binding site for residue GNP A 201 source : AC1 21) chain A residue 145 type sequence S description binding site for residue GNP A 201 source : AC1 22) chain A residue 146 type sequence A description binding site for residue GNP A 201 source : AC1 23) chain A residue 147 type sequence K description binding site for residue GNP A 201 source : AC1 24) chain A residue 17 type sequence S description binding site for residue MG A 202 source : AC2 25) chain A residue 35 type sequence T description binding site for residue MG A 202 source : AC2 26) chain B residue 878 type sequence M description binding site for residue EAS B 2001 source : AC3 27) chain B residue 879 type sequence N description binding site for residue EAS B 2001 source : AC3 28) chain B residue 884 type sequence Y description binding site for residue EAS B 2001 source : AC3 29) chain B residue 890 type sequence F description binding site for residue EAS B 2001 source : AC3 30) chain B residue 898 type sequence K description binding site for residue EAS B 2001 source : AC3 31) chain B residue 902 type sequence E description binding site for residue EAS B 2001 source : AC3 32) chain B residue 905 type sequence H description binding site for residue EAS B 2001 source : AC3 33) chain B residue 566 type sequence Q description binding site for residue FMT B 2002 source : AC4 34) chain B residue 567 type sequence M description binding site for residue FMT B 2002 source : AC4 35) chain B residue 616 type sequence H description binding site for residue FMT B 2002 source : AC4 36) chain B residue 617 type sequence M description binding site for residue FMT B 2002 source : AC4 37) chain A residue 128 type sequence R description binding site for residue FMT B 2003 source : AC5 38) chain B residue 767 type sequence R description binding site for residue FMT B 2003 source : AC5 39) chain B residue 768 type sequence P description binding site for residue FMT B 2003 source : AC5 40) chain A residue 37 type sequence E description binding site for residue FMT B 2004 source : AC6 41) chain A residue 67 type sequence M description binding site for residue FMT B 2004 source : AC6 42) chain A residue 70 type sequence Q description binding site for residue FMT B 2004 source : AC6 43) chain B residue 619 type sequence A description binding site for residue FMT B 2004 source : AC6 44) chain B residue 688 type sequence R description binding site for residue FMT B 2004 source : AC6 45) chain B residue 611 type sequence E description binding site for residue FMT B 2005 source : AC7 46) chain B residue 615 type sequence Y description binding site for residue FMT B 2005 source : AC7 47) chain B residue 616 type sequence H description binding site for residue FMT B 2005 source : AC7 48) chain B residue 647 type sequence R description binding site for residue FMT B 2005 source : AC7 49) chain B residue 681 type sequence Y description binding site for residue FMT B 2005 source : AC7 50) chain B residue 1031 type sequence Y description binding site for residue FMT B 2006 source : AC8 51) chain B residue 793 type sequence S description binding site for residue GOL B 2007 source : AC9 52) chain B residue 794 type sequence D description binding site for residue GOL B 2007 source : AC9 53) chain B residue 978 type sequence P description binding site for residue GOL B 2007 source : AC9 54) chain B residue 979 type sequence Y description binding site for residue GOL B 2007 source : AC9 55) chain B residue 786 type sequence R description binding site for residue GOL B 2008 source : AD1 56) chain B residue 864 type sequence E description binding site for residue GOL B 2008 source : AD1 57) chain B residue 1040 type sequence V description binding site for residue GOL B 2008 source : AD1 58) chain B residue 938 type sequence L description binding site for residue FMT C 201 source : AD2 59) chain C residue 15 type sequence G description binding site for residue FMT C 201 source : AD2 60) chain C residue 16 type sequence K description binding site for residue FMT C 201 source : AD2 61) chain C residue 17 type sequence S description binding site for residue FMT C 201 source : AD2 62) chain C residue 59 type sequence A description binding site for residue FMT C 201 source : AD2 63) chain C residue 85 type sequence N description binding site for residue NA C 202 source : AD3 64) chain C residue 86 type sequence N description binding site for residue NA C 202 source : AD3 65) chain C residue 87 type sequence T description binding site for residue NA C 202 source : AD3 66) chain C residue 124 type sequence T description binding site for residue NA C 202 source : AD3 67) chain B residue 927-960 type prosite sequence VPFFGIYLTNILKTEEGNPEVLKRHGKELINFSK description RASGEF Ras Guanine-nucleotide exchange factors domain signature. VPFfGiyLtNIlkteegnpevlkrhgkel.................INFsK source prosite : PS00720 68) chain C residue 13 type BINDING sequence G description BINDING => ECO:0000269|PubMed:16698776 source Swiss-Prot : SWS_FT_FI1 69) chain C residue 29 type BINDING sequence V description BINDING => ECO:0000269|PubMed:16698776 source Swiss-Prot : SWS_FT_FI1 70) chain C residue 59 type BINDING sequence A description BINDING => ECO:0000269|PubMed:16698776 source Swiss-Prot : SWS_FT_FI1 71) chain C residue 116 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16698776 source Swiss-Prot : SWS_FT_FI1 72) chain C residue 145 type BINDING sequence S description BINDING => ECO:0000269|PubMed:16698776 source Swiss-Prot : SWS_FT_FI1 73) chain C residue 1 type MOD_RES sequence M description N-acetylmethionine; in GTPase HRas; alternate => ECO:0000269|Ref.12 source Swiss-Prot : SWS_FT_FI2 74) chain C residue 2 type MOD_RES sequence T description N-acetylthreonine; in GTPase HRas, N-terminally processed => ECO:0000269|Ref.12 source Swiss-Prot : SWS_FT_FI3 75) chain C residue 118 type MOD_RES sequence C description S-nitrosocysteine => ECO:0000269|PubMed:9020151 source Swiss-Prot : SWS_FT_FI4 76) chain C residue 35 type CARBOHYD sequence T description (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269|PubMed:19744486, ECO:0000269|PubMed:8626575, ECO:0000269|PubMed:8626586, ECO:0000269|PubMed:9632667 source Swiss-Prot : SWS_FT_FI5

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