eF-site ID 6buq-ABCD PDB Code 6buq Chain A, B, C, D click to enlarge Title Crystal structures of cyanuric acid hydrolase from Moorella thermoacetica complexed with barbituric acid Classification HYDROLASE Compound Cyanuric acid amidohydrolase Source (CAH_MOOTA) Sequence A:  MQKVEVFRIPTASPDDISGLATLIDSGKINPAEIVAILGK TEGNGCVNDFTRGFATQSLAMYLAEKLGISREEVVKKVAF IMSGGTEGVMTPHITVFVRKDVAAPAAPGKRLAVGVAFTR DFLPEELGRMEQVNEVARAVKEAMKDAQIDDPRDVHFVQI KCPLLTAERIEDAKRRGKDVVVNDTYKSMAYSRGASALGV ALALGEISADKISNEAICHDWNLYSSVASTSAGVELLNDE IIVVGNSTNSASDLVIGHSVMKDAIDADAVRAALKDAGIR SDDEMDRIVNVLAKAEAASSGTVRGRRNTMLDDSDINHTR SARAVVNAVIASVVGDPMVYVSGGAEHQGPDGGGPIAVIA RV B:  HMQKVEVFRIPTASPDDISGLATLIDSGKINPAEIVAILG KTEGNGCVNDFTRGFATQSLAMYLAEKLGISREEVVKKVA FIMSGGTEGVMTPHITVFVRKDVAAPAAPGKRLAVGVAFT RDFLPEELGRMEQVNEVARAVKEAMKDAQIDDPRDVHFVQ IKCPLLTAERIEDAKRRGKDVVVNDTYKSMAYSRGASALG VALALGEISADKISNEAICHDWNLYSSVASTSAGVELLND EIIVVGNSTNSASDLVIGHSVMKDAIDADAVRAALKDAGI RSDDEMDRIVNVLAKAEAASSGTVRGRRNTMLDDSDINHT RSARAVVNAVIASVVGDPMVYVSGGAEHQGPDGGGPIAVI ARV C:  MQKVEVFRIPTASPDDISGLATLIDSGKINPAEIVAILGK TEGNGCVNDFTRGFATQSLAMYLAEKLGISREEVVKKVAF IMSGGTEGVMTPHITVFVRKDVAAPAAPGKRLAVGVAFTR DFLPEELGRMEQVNEVARAVKEAMKDAQIDDPRDVHFVQI KCPLLTAERIEDAKRRGKDVVVNDTYKSMAYSRGASALGV ALALGEISADKISNEAICHDWNLYSSVASTSAGVELLNDE IIVVGNSTNSASDLVIGHSVMKDAIDADAVRAALKDAGIR SDDEMDRIVNVLAKAEAASSGTVRGRRNTMLDDSDINHTR SARAVVNAVIASVVGDPMVYVSGGAEHQGPDGGGPIAVIA RV D:  MQKVEVFRIPTASPDDISGLATLIDSGKINPAEIVAILGK TEGNGCVNDFTRGFATQSLAMYLAEKLGISREEVVKKVAF IMSGGTEGVMTPHITVFVRKDVAAPPGKRLAVGVAFTRDF LPEELGRMEQVNEVARAVKEAMKDAQIDDPRDVHFVQIKC PLLTAERIEDAKRRGKDVVVNDTYKSMAYSRGASALGVAL ALGEISADKISNEAICHDWNLYSSVASTSAGVELLNDEII VVGNSTNSASDLVIGHSVMKDAIDADAVRAALKDAGIRSD DEMDRIVNVLAKAEAASSGTVRGRRNTMLDDSDINHTRSA RAVVNAVIASVVGDPMVYVSGGAEHQGPDGGGPIAVIARV Description Functional site 1) chain A residue 45 type sequence G description binding site for residue MLI A 401 source : AC1 2) chain A residue 52 type sequence R description binding site for residue MLI A 401 source : AC1 3) chain A residue 83 type sequence S description binding site for residue MLI A 401 source : AC1 4) chain A residue 84 type sequence G description binding site for residue MLI A 401 source : AC1 5) chain A residue 161 type sequence K description binding site for residue MLI A 401 source : AC1 6) chain A residue 231 type sequence S description binding site for residue MLI A 401 source : AC1 7) chain A residue 232 type sequence A description binding site for residue MLI A 401 source : AC1 8) chain A residue 328 type sequence R description binding site for residue MLI A 401 source : AC1 9) chain A residue 347 type sequence S description binding site for residue MLI A 401 source : AC1 10) chain A residue 348 type sequence G description binding site for residue MLI A 401 source : AC1 11) chain A residue 301 type sequence E description binding site for residue CA A 402 source : AC2 12) chain A residue 350 type sequence A description binding site for residue CA A 402 source : AC2 13) chain A residue 353 type sequence Q description binding site for residue CA A 402 source : AC2 14) chain A residue 354 type sequence G description binding site for residue CA A 402 source : AC2 15) chain A residue 355 type sequence P description binding site for residue CA A 402 source : AC2 16) chain A residue 358 type sequence G description binding site for residue CA A 402 source : AC2 17) chain A residue 54 type sequence F description binding site for residue NA A 403 source : AC3 18) chain A residue 57 type sequence Q description binding site for residue NA A 403 source : AC3 19) chain B residue 57 type sequence Q description binding site for residue NA A 403 source : AC3 20) chain A residue 53 type sequence G description binding site for residue PDO A 404 source : AC4 21) chain A residue 56 type sequence T description binding site for residue PDO A 404 source : AC4 22) chain A residue 57 type sequence Q description binding site for residue PDO A 404 source : AC4 23) chain A residue 47 type sequence V description binding site for residue PDO A 405 source : AC5 24) chain A residue 184 type sequence D description binding site for residue PDO A 405 source : AC5 25) chain A residue 185 type sequence T description binding site for residue PDO A 405 source : AC5 26) chain A residue 186 type sequence Y description binding site for residue PDO A 405 source : AC5 27) chain D residue 316 type sequence L description binding site for residue PDO A 405 source : AC5 28) chain D residue 318 type sequence D description binding site for residue PDO A 405 source : AC5 29) chain D residue 319 type sequence S description binding site for residue PDO A 405 source : AC5 30) chain A residue 49 type sequence D description binding site for residue CL A 406 source : AC6 31) chain A residue 50 type sequence F description binding site for residue CL A 406 source : AC6 32) chain A residue 52 type sequence R description binding site for residue CL A 406 source : AC6 33) chain A residue 53 type sequence G description binding site for residue CL A 406 source : AC6 34) chain A residue 234 type sequence V description binding site for residue CL A 406 source : AC6 35) chain A residue 235 type sequence E description binding site for residue CL A 406 source : AC6 36) chain B residue 45 type sequence G description binding site for residue BR8 B 401 source : AC7 37) chain B residue 52 type sequence R description binding site for residue BR8 B 401 source : AC7 38) chain B residue 83 type sequence S description binding site for residue BR8 B 401 source : AC7 39) chain B residue 84 type sequence G description binding site for residue BR8 B 401 source : AC7 40) chain B residue 193 type sequence R description binding site for residue BR8 B 401 source : AC7 41) chain B residue 231 type sequence S description binding site for residue BR8 B 401 source : AC7 42) chain B residue 232 type sequence A description binding site for residue BR8 B 401 source : AC7 43) chain B residue 328 type sequence R description binding site for residue BR8 B 401 source : AC7 44) chain B residue 347 type sequence S description binding site for residue BR8 B 401 source : AC7 45) chain B residue 348 type sequence G description binding site for residue BR8 B 401 source : AC7 46) chain B residue 301 type sequence E description binding site for residue CA B 402 source : AC8 47) chain B residue 350 type sequence A description binding site for residue CA B 402 source : AC8 48) chain B residue 353 type sequence Q description binding site for residue CA B 402 source : AC8 49) chain B residue 354 type sequence G description binding site for residue CA B 402 source : AC8 50) chain B residue 355 type sequence P description binding site for residue CA B 402 source : AC8 51) chain B residue 358 type sequence G description binding site for residue CA B 402 source : AC8 52) chain B residue 221 type sequence W description binding site for residue PDO B 403 source : AC9 53) chain B residue 301 type sequence E description binding site for residue PDO B 403 source : AC9 54) chain B residue 350 type sequence A description binding site for residue PDO B 403 source : AC9 55) chain B residue 351 type sequence E description binding site for residue PDO B 403 source : AC9 56) chain B residue 356 type sequence D description binding site for residue PDO B 403 source : AC9 57) chain B residue 5 type sequence E description binding site for residue PDO B 404 source : AD1 58) chain B residue 6 type sequence V description binding site for residue PDO B 404 source : AD1 59) chain B residue 254 type sequence L description binding site for residue PDO B 404 source : AD1 60) chain B residue 366 type sequence R description binding site for residue PDO B 404 source : AD1 61) chain A residue 340 type sequence G description binding site for residue CL B 405 source : AD2 62) chain B residue 28 type sequence K description binding site for residue CL B 405 source : AD2 63) chain C residue 309 type sequence R description binding site for residue CL B 405 source : AD2 64) chain C residue 45 type sequence G description binding site for residue BR8 C 401 source : AD3 65) chain C residue 52 type sequence R description binding site for residue BR8 C 401 source : AD3 66) chain C residue 83 type sequence S description binding site for residue BR8 C 401 source : AD3 67) chain C residue 84 type sequence G description binding site for residue BR8 C 401 source : AD3 68) chain C residue 161 type sequence K description binding site for residue BR8 C 401 source : AD3 69) chain C residue 189 type sequence M description binding site for residue BR8 C 401 source : AD3 70) chain C residue 193 type sequence R description binding site for residue BR8 C 401 source : AD3 71) chain C residue 231 type sequence S description binding site for residue BR8 C 401 source : AD3 72) chain C residue 232 type sequence A description binding site for residue BR8 C 401 source : AD3 73) chain C residue 328 type sequence R description binding site for residue BR8 C 401 source : AD3 74) chain C residue 347 type sequence S description binding site for residue BR8 C 401 source : AD3 75) chain C residue 348 type sequence G description binding site for residue BR8 C 401 source : AD3 76) chain C residue 301 type sequence E description binding site for residue CA C 402 source : AD4 77) chain C residue 350 type sequence A description binding site for residue CA C 402 source : AD4 78) chain C residue 353 type sequence Q description binding site for residue CA C 402 source : AD4 79) chain C residue 354 type sequence G description binding site for residue CA C 402 source : AD4 80) chain C residue 355 type sequence P description binding site for residue CA C 402 source : AD4 81) chain C residue 358 type sequence G description binding site for residue CA C 402 source : AD4 82) chain C residue 8 type sequence R description binding site for residue PDO C 403 source : AD5 83) chain C residue 10 type sequence P description binding site for residue PDO C 403 source : AD5 84) chain C residue 5 type sequence E description binding site for residue PDO C 404 source : AD6 85) chain C residue 6 type sequence V description binding site for residue PDO C 404 source : AD6 86) chain C residue 254 type sequence L description binding site for residue PDO C 404 source : AD6 87) chain A residue 87 type sequence E description binding site for residue PDO C 405 source : AD7 88) chain A residue 88 type sequence G description binding site for residue PDO C 405 source : AD7 89) chain C residue 321 type sequence I description binding site for residue PDO C 405 source : AD7 90) chain C residue 326 type sequence S description binding site for residue PDO C 405 source : AD7 91) chain C residue 329 type sequence A description binding site for residue PDO C 405 source : AD7 92) chain C residue 221 type sequence W description binding site for residue PDO C 406 source : AD8 93) chain C residue 301 type sequence E description binding site for residue PDO C 406 source : AD8 94) chain C residue 302 type sequence A description binding site for residue PDO C 406 source : AD8 95) chain C residue 351 type sequence E description binding site for residue PDO C 406 source : AD8 96) chain C residue 356 type sequence D description binding site for residue PDO C 406 source : AD8 97) chain D residue 45 type sequence G description binding site for residue BR8 D 401 source : AD9 98) chain D residue 52 type sequence R description binding site for residue BR8 D 401 source : AD9 99) chain D residue 83 type sequence S description binding site for residue BR8 D 401 source : AD9 100) chain D residue 84 type sequence G description binding site for residue BR8 D 401 source : AD9 101) chain D residue 189 type sequence M description binding site for residue BR8 D 401 source : AD9 102) chain D residue 193 type sequence R description binding site for residue BR8 D 401 source : AD9 103) chain D residue 231 type sequence S description binding site for residue BR8 D 401 source : AD9 104) chain D residue 232 type sequence A description binding site for residue BR8 D 401 source : AD9 105) chain D residue 328 type sequence R description binding site for residue BR8 D 401 source : AD9 106) chain D residue 347 type sequence S description binding site for residue BR8 D 401 source : AD9 107) chain D residue 348 type sequence G description binding site for residue BR8 D 401 source : AD9 108) chain D residue 301 type sequence E description binding site for residue CA D 402 source : AE1 109) chain D residue 350 type sequence A description binding site for residue CA D 402 source : AE1 110) chain D residue 353 type sequence Q description binding site for residue CA D 402 source : AE1 111) chain D residue 354 type sequence G description binding site for residue CA D 402 source : AE1 112) chain D residue 355 type sequence P description binding site for residue CA D 402 source : AE1 113) chain D residue 358 type sequence G description binding site for residue CA D 402 source : AE1 114) chain B residue 87 type sequence E description binding site for residue PDO D 403 source : AE2 115) chain B residue 88 type sequence G description binding site for residue PDO D 403 source : AE2 116) chain D residue 321 type sequence I description binding site for residue PDO D 403 source : AE2 117) chain D residue 326 type sequence S description binding site for residue PDO D 403 source : AE2 118) chain D residue 329 type sequence A description binding site for residue PDO D 403 source : AE2 119) chain D residue 221 type sequence W description binding site for residue PEG D 404 source : AE3 120) chain D residue 301 type sequence E description binding site for residue PEG D 404 source : AE3 121) chain D residue 302 type sequence A description binding site for residue PEG D 404 source : AE3 122) chain D residue 323 type sequence H description binding site for residue PEG D 404 source : AE3 123) chain D residue 351 type sequence E description binding site for residue PEG D 404 source : AE3 124) chain D residue 356 type sequence D description binding site for residue PEG D 404 source : AE3 125) chain A residue 161 type ACT_SITE sequence K description ACT_SITE => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI1 126) chain B residue 161 type ACT_SITE sequence K description ACT_SITE => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI1 127) chain C residue 161 type ACT_SITE sequence K description ACT_SITE => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI1 128) chain D residue 161 type ACT_SITE sequence K description ACT_SITE => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI1 129) chain A residue 231 type ACT_SITE sequence S description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI2 130) chain B residue 231 type ACT_SITE sequence S description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI2 131) chain C residue 231 type ACT_SITE sequence S description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI2 132) chain D residue 231 type ACT_SITE sequence S description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI2 133) chain A residue 359 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 134) chain A residue 360 type BINDING sequence P description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 135) chain A residue 363 type BINDING sequence V description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 136) chain B residue 52 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 137) chain B residue 83 type BINDING sequence S description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 138) chain B residue 193 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 139) chain B residue 231 type BINDING sequence S description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 140) chain B residue 306 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 141) chain B residue 333 type BINDING sequence A description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 142) chain B residue 352 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 143) chain B residue 355 type BINDING sequence P description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 144) chain B residue 358 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 145) chain B residue 359 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 146) chain B residue 360 type BINDING sequence P description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 147) chain B residue 363 type BINDING sequence V description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 148) chain C residue 52 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 149) chain C residue 83 type BINDING sequence S description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 150) chain C residue 193 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 151) chain C residue 231 type BINDING sequence S description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 152) chain C residue 306 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 153) chain C residue 333 type BINDING sequence A description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 154) chain C residue 352 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 155) chain C residue 355 type BINDING sequence P description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 156) chain C residue 358 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 157) chain C residue 359 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 158) chain C residue 360 type BINDING sequence P description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 159) chain C residue 363 type BINDING sequence V description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 160) chain D residue 52 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 161) chain D residue 83 type BINDING sequence S description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 162) chain D residue 193 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 163) chain D residue 231 type BINDING sequence S description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 164) chain D residue 306 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 165) chain D residue 333 type BINDING sequence A description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 166) chain D residue 352 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 167) chain D residue 355 type BINDING sequence P description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 168) chain D residue 358 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 169) chain D residue 359 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 170) chain D residue 360 type BINDING sequence P description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 171) chain D residue 363 type BINDING sequence V description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 172) chain A residue 306 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 173) chain A residue 333 type BINDING sequence A description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 174) chain A residue 352 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 175) chain A residue 355 type BINDING sequence P description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 176) chain A residue 358 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 177) chain A residue 193 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 178) chain A residue 52 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 179) chain A residue 83 type BINDING sequence S description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 180) chain A residue 231 type BINDING sequence S description BINDING => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI3 181) chain A residue 329 type SITE sequence A description Important for substrate specificity => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI4 182) chain B residue 329 type SITE sequence A description Important for substrate specificity => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI4 183) chain C residue 329 type SITE sequence A description Important for substrate specificity => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI4 184) chain D residue 329 type SITE sequence A description Important for substrate specificity => ECO:0000255|HAMAP-Rule:MF_01989 source Swiss-Prot : SWS_FT_FI4

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