Title
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Structure of the cold- and menthol-sensing ion channel TRPM8 |
Classification
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TRANSPORT PROTEIN |
Compound
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Transient receptor potential cation channel subfamily M member 8 |
Source
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(6BPQ) |
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Sequence
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A: |
XXXXXXXXXXXXXXXXXXXXCDTDSETLYDLMTQHWHLKT
PNLVISVTKNFALKPRMRKIFSRLIYIAQSKGAWIFTGLM
KYIGEVVRDNTISRSSEENVVAIGIAXXXXXLKRDPLYCL
DNNHTHLLLVEAKVRTQLEKYISERVIPESNYGGKIPIVC
FAQGGGKETLKSINVAIKSKIPCVVVEGSIADVIASLVSS
CVKESLLRFLPRTISRLSEEETESWIKWIKEVLESPHLLT
VIKIEIVSNAISFALYKAFSTNEHDRDNWNGQLKLLLEWN
QLDLASDEIFTNDRNWESADLQDVMFTALVKDRPKFVRLF
LENGLNLRKFLTTEVLRELYTNNFSSLVFKNLQIAKNSYN
DALLTFVWKMVEDFRRGRHPLQALFIWSVLQNKKELSKVI
WEQTRGCTLAALGASKLLKSMAKVKNDINAAGESEELANE
YETRAVELFTECYSNDEDLAEQLLTYSCEAWGGSNCLELA
VEARDQQFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLF
FFPLIGCGFISFRKKKLFLYYVSFFTSPFVVFSWNVIFYI
AFLLLFAYVLLMDFQKEPTALEIILYVLVFILLCDEVRQW
YMNGSKYFSDLWNVMDTLAIFYFIAGIVFRLHSSSWYSGR
VIFCLDYIVFTLRLIHIFTVSRNLGPKIIMLQRMMIDVFF
FLFLFAVWMVAFGVARQGILRWEWIFRSVIYEPYLAMNNQ
PRFPEWITIPLVCIYMLSTNILLVNLLVADQVWKFQRFFL
VQEYCSRLTXXXXXXXXXXXXXXXXXXRNEDNEILAWEAV
MKENYLVKINTXXXXXXXXXXXXXXXXXXXXXXXX
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B: |
XXXXXXXXXXXXXXXXXXXXCDTDSETLYDLMTQHWHLKT
PNLVISVTKNFALKPRMRKIFSRLIYIAQSKGAWIFTGLM
KYIGEVVRDNTISRSSEENVVAIGIAXXXXXLKRDPLYCL
DNNHTHLLLVEAKVRTQLEKYISERVIPESNYGGKIPIVC
FAQGGGKETLKSINVAIKSKIPCVVVEGSIADVIASLVSS
CVKESLLRFLPRTISRLSEEETESWIKWIKEVLESPHLLT
VIKIEIVSNAISFALYKAFSTNEHDRDNWNGQLKLLLEWN
QLDLASDEIFTNDRNWESADLQDVMFTALVKDRPKFVRLF
LENGLNLRKFLTTEVLRELYTNNFSSLVFKNLQIAKNSYN
DALLTFVWKMVEDFRRGRHPLQALFIWSVLQNKKELSKVI
WEQTRGCTLAALGASKLLKSMAKVKNDINAAGESEELANE
YETRAVELFTECYSNDEDLAEQLLTYSCEAWGGSNCLELA
VEARDQQFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLF
FFPLIGCGFISFRKKKLFLYYVSFFTSPFVVFSWNVIFYI
AFLLLFAYVLLMDFQKEPTALEIILYVLVFILLCDEVRQW
YMNGSKYFSDLWNVMDTLAIFYFIAGIVFRLHSSSWYSGR
VIFCLDYIVFTLRLIHIFTVSRNLGPKIIMLQRMMIDVFF
FLFLFAVWMVAFGVARQGILRWEWIFRSVIYEPYLAMNNQ
PRFPEWITIPLVCIYMLSTNILLVNLLVADQVWKFQRFFL
VQEYCSRLTXXXXXXXXXXXXXXXXXXRNEDNEILAWEAV
MKENYLVKINTXXXXXXXXXXXXXXXXXXXXXXXX
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C: |
XXXXXXXXXXXXXXXXXXXXCDTDSETLYDLMTQHWHLKT
PNLVISVTKNFALKPRMRKIFSRLIYIAQSKGAWIFTGLM
KYIGEVVRDNTISRSSEENVVAIGIAXXXXXLKRDPLYCL
DNNHTHLLLVEAKVRTQLEKYISERVIPESNYGGKIPIVC
FAQGGGKETLKSINVAIKSKIPCVVVEGSIADVIASLVSS
CVKESLLRFLPRTISRLSEEETESWIKWIKEVLESPHLLT
VIKIEIVSNAISFALYKAFSTNEHDRDNWNGQLKLLLEWN
QLDLASDEIFTNDRNWESADLQDVMFTALVKDRPKFVRLF
LENGLNLRKFLTTEVLRELYTNNFSSLVFKNLQIAKNSYN
DALLTFVWKMVEDFRRGRHPLQALFIWSVLQNKKELSKVI
WEQTRGCTLAALGASKLLKSMAKVKNDINAAGESEELANE
YETRAVELFTECYSNDEDLAEQLLTYSCEAWGGSNCLELA
VEARDQQFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLF
FFPLIGCGFISFRKKKLFLYYVSFFTSPFVVFSWNVIFYI
AFLLLFAYVLLMDFQKEPTALEIILYVLVFILLCDEVRQW
YMNGSKYFSDLWNVMDTLAIFYFIAGIVFRLHSSSWYSGR
VIFCLDYIVFTLRLIHIFTVSRNLGPKIIMLQRMMIDVFF
FLFLFAVWMVAFGVARQGILRWEWIFRSVIYEPYLAMNNQ
PRFPEWITIPLVCIYMLSTNILLVNLLVADQVWKFQRFFL
VQEYCSRLTXXXXXXXXXXXXXXXXXXRNEDNEILAWEAV
MKENYLVKINTXXXXXXXXXXXXXXXXXXXXXXXX
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D: |
XXXXXXXXXXXXXXXXXXXXCDTDSETLYDLMTQHWHLKT
PNLVISVTKNFALKPRMRKIFSRLIYIAQSKGAWIFTGLM
KYIGEVVRDNTISRSSEENVVAIGIAXXXXXLKRDPLYCL
DNNHTHLLLVEAKVRTQLEKYISERVIPESNYGGKIPIVC
FAQGGGKETLKSINVAIKSKIPCVVVEGSIADVIASLVSS
CVKESLLRFLPRTISRLSEEETESWIKWIKEVLESPHLLT
VIKIEIVSNAISFALYKAFSTNEHDRDNWNGQLKLLLEWN
QLDLASDEIFTNDRNWESADLQDVMFTALVKDRPKFVRLF
LENGLNLRKFLTTEVLRELYTNNFSSLVFKNLQIAKNSYN
DALLTFVWKMVEDFRRGRHPLQALFIWSVLQNKKELSKVI
WEQTRGCTLAALGASKLLKSMAKVKNDINAAGESEELANE
YETRAVELFTECYSNDEDLAEQLLTYSCEAWGGSNCLELA
VEARDQQFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLF
FFPLIGCGFISFRKKKLFLYYVSFFTSPFVVFSWNVIFYI
AFLLLFAYVLLMDFQKEPTALEIILYVLVFILLCDEVRQW
YMNGSKYFSDLWNVMDTLAIFYFIAGIVFRLHSSSWYSGR
VIFCLDYIVFTLRLIHIFTVSRNLGPKIIMLQRMMIDVFF
FLFLFAVWMVAFGVARQGILRWEWIFRSVIYEPYLAMNNQ
PRFPEWITIPLVCIYMLSTNILLVNLLVADQVWKFQRFFL
VQEYCSRLTXXXXXXXXXXXXXXXXXXRNEDNEILAWEAV
MKENYLVKINTXXXXXXXXXXXXXXXXXXXXXXXX
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Description
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