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eF-site ID
|
6bp2-ABHL |
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PDB Code
|
6bp2 |
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Chain
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A, B, H, L |
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click to enlarge
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Title
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Therapeutic human monoclonal antibody MR191 bound to a marburgvirus glycoprotein |
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Classification
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VIRAL PROTEIN/immune system |
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Compound
|
Envelope glycoprotein |
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Source
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(6BP2) |
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Sequence
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A: |
VDSVCSGTLQKTEDVHLMGFTLSGQKVADSPLEASKRWAF
RTGVPPKNVEYTEGEEAKTCYNISVTDPSGKSLLLDPPSN
IRDYPKCKTVHHIQGQNPHAQGIALHLWGAFFLYDRVAST
TMYRGKVFTEGNIAAMIVNKTVHRMIFS
|
| B: |
DESPSFNTSTNISLTFSYFPDKSGENENDCDAELRIWSVQ
EDDLAAGLSWIPFFGPGIEGLYTAGLIKNQNNLVCRLRRL
ANQTAKSLELLLRVTTEERTFSLINRHAIDFLLTRWGGTC
KVLGPDCCIGIEDLSKNISEQIDKIRK
|
| H: |
LQLQESGPGLVKPSETLSLSCTVSGVSISDNSYYWGWIRQ
PPGKGLEWIGTISYSGNTYYNPSLKSRVSISGDTSKHQLS
LKVSSVTAADTAVYYCARQRIVSGFVEWLSKFDYWGQGTL
VTVSSASTKGPSVFPLAPSTAALGCLVKDYFPEPVTVSWN
SGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYI
CNVNHKPSNTKVDKKVEPK
|
| L: |
SVLTQPPSVSGAPGQRVTISCTGSSSNIGAGFDVHWYQQL
PGTAPKLLIYDNNNRPSGVPDRFSGSKSGTSASLAITGLQ
AEDEADYYCQSYDTSLSGPVVFGGGTKLTVLQPKAAPSVT
LFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPIK
AGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVT
HEGSTVEKTVAPTEC
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Description
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Functional site
|
|
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1)
|
chain |
B |
| residue |
475 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine; by host => ECO:0000255
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
2)
|
chain |
B |
| residue |
487 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine; by host => ECO:0000255
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
3)
|
chain |
B |
| residue |
564 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine; by host => ECO:0000255
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
4)
|
chain |
B |
| residue |
619 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine; by host => ECO:0000255
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
5)
|
chain |
L |
| residue |
196-202 |
| type |
prosite |
| sequence |
YSCQVTH
|
| description |
IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH
|
| source |
prosite : PS00290
|
|
|
6)
|
chain |
H |
| residue |
207-213 |
| type |
prosite |
| sequence |
YICNVNH
|
| description |
IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH
|
| source |
prosite : PS00290
|
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