eF-site ID 6bkw-A PDB Code 6bkw Chain A click to enlarge Title BTK complex with compound 12 Classification TRANSFERASE Compound Tyrosine-protein kinase BTK Source (BTK_HUMAN) Sequence A:  GSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMI KEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFI ITEYMANGXLLNYLREMRHRFQTQQLLEMCKDVCEAMEYL ESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYT SSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYS LGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYS CWHEKADERPTFKILLSNILDVMDEN Description (1)  Tyrosine-protein kinase BTK (E.C.2.7.10.2) Functional site 1) chain A residue 466 type sequence K description binding site for residue SO4 A 701 source : AC1 2) chain A residue 487 type sequence R description binding site for residue SO4 A 701 source : AC1 3) chain A residue 490 type sequence R description binding site for residue SO4 A 701 source : AC1 4) chain A residue 595 type sequence K description binding site for residue SO4 A 701 source : AC1 5) chain A residue 592 type sequence S description binding site for residue SO4 A 702 source : AC2 6) chain A residue 595 type sequence K description binding site for residue SO4 A 702 source : AC2 7) chain A residue 617 type sequence Y description binding site for residue SO4 A 702 source : AC2 8) chain A residue 619 type sequence P description binding site for residue SO4 A 702 source : AC2 9) chain A residue 620 type sequence H description binding site for residue SO4 A 702 source : AC2 10) chain A residue 490 type sequence R description binding site for residue SO4 A 703 source : AC3 11) chain A residue 491 type sequence H description binding site for residue SO4 A 703 source : AC3 12) chain A residue 637 type sequence K description binding site for residue SO4 A 703 source : AC3 13) chain A residue 408 type sequence L description binding site for residue DXM A 704 source : AC4 14) chain A residue 410 type sequence T description binding site for residue DXM A 704 source : AC4 15) chain A residue 411 type sequence G description binding site for residue DXM A 704 source : AC4 16) chain A residue 413 type sequence F description binding site for residue DXM A 704 source : AC4 17) chain A residue 416 type sequence V description binding site for residue DXM A 704 source : AC4 18) chain A residue 428 type sequence A description binding site for residue DXM A 704 source : AC4 19) chain A residue 430 type sequence K description binding site for residue DXM A 704 source : AC4 20) chain A residue 474 type sequence T description binding site for residue DXM A 704 source : AC4 21) chain A residue 475 type sequence E description binding site for residue DXM A 704 source : AC4 22) chain A residue 476 type sequence Y description binding site for residue DXM A 704 source : AC4 23) chain A residue 477 type sequence M description binding site for residue DXM A 704 source : AC4 24) chain A residue 478 type sequence A description binding site for residue DXM A 704 source : AC4 25) chain A residue 480 type sequence G description binding site for residue DXM A 704 source : AC4 26) chain A residue 526 type sequence N description binding site for residue DXM A 704 source : AC4 27) chain A residue 528 type sequence L description binding site for residue DXM A 704 source : AC4 28) chain A residue 539 type sequence D description binding site for residue DXM A 704 source : AC4 29) chain A residue 551 type sequence Y description binding site for residue DXM A 704 source : AC4 30) chain A residue 395 type sequence W description binding site for residue FPZ A 705 source : AC5 31) chain A residue 421 type sequence W description binding site for residue FPZ A 705 source : AC5 32) chain A residue 425 type sequence Y description binding site for residue FPZ A 705 source : AC5 33) chain A residue 426 type sequence D description binding site for residue FPZ A 705 source : AC5 34) chain A residue 461 type sequence Y description binding site for residue FPZ A 705 source : AC5 35) chain A residue 598 type sequence Y description binding site for residue FPZ A 705 source : AC5 36) chain A residue 614 type sequence L description binding site for residue FPZ A 705 source : AC5 37) chain A residue 615 type sequence R description binding site for residue FPZ A 705 source : AC5 38) chain A residue 616 type sequence L description binding site for residue FPZ A 705 source : AC5 39) chain A residue 617 type sequence Y description binding site for residue FPZ A 705 source : AC5 40) chain A residue 418 type sequence Y description binding site for residue GOL A 706 source : AC6 41) chain A residue 476 type sequence Y description binding site for residue GOL A 706 source : AC6 42) chain A residue 618 type sequence R description binding site for residue GOL A 707 source : AC7 43) chain A residue 620 type sequence H description binding site for residue GOL A 707 source : AC7 44) chain A residue 621 type sequence L description binding site for residue GOL A 707 source : AC7 45) chain A residue 622 type sequence A description binding site for residue GOL A 707 source : AC7 46) chain A residue 604 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI6 47) chain A residue 623 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:15375214 source Swiss-Prot : SWS_FT_FI8 48) chain A residue 551 type MOD_RES sequence Y description Phosphotyrosine; by LYN and SYK => ECO:0000269|PubMed:8630736, ECO:0000269|PubMed:9012831 source Swiss-Prot : SWS_FT_FI5 49) chain A residue 617 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000269|PubMed:15375214 source Swiss-Prot : SWS_FT_FI7 50) chain A residue 408-430 type prosite sequence LGTGQFGVVKYGKWRGQYDVAIK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGTGQFGVVKyGkwrgqyd...........VAIK source prosite : PS00107 51) chain A residue 517-529 type prosite sequence FLHRDLAARNCLV description PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FLHrDLAARNCLV source prosite : PS00109 52) chain A residue 521 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 53) chain A residue 408 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 54) chain A residue 430 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 55) chain A residue 474 type BINDING sequence T description BINDING => ECO:0000269|PubMed:20052711, ECO:0007744|PDB:3K54, ECO:0007744|PDB:3OCT source Swiss-Prot : SWS_FT_FI3 56) chain A residue 542 type BINDING sequence L description BINDING => ECO:0000269|PubMed:21280133, ECO:0007744|PDB:3PIY source Swiss-Prot : SWS_FT_FI4

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