eF-site ID 6bd4-A PDB Code 6bd4 Chain A click to enlarge Title Crystal structure of human apo-Frizzled4 receptor Classification MEMBRANE PROTEIN Compound Frizzled-4/Rubredoxin chimeric protein Source (FZD4_HUMAN) Sequence A:  CHSVGTNSDQYIWVKRSLNCVLKCGYDAGLYSRSAKEFTD IWMAVWASLCFISTAFTVLTFLIDSSRFSYPERPIIFLSM CYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNT GCAIIFLLLYFFGMASSIWWVILTLTWFLAAGLKWGHEAI EMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVG NQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNM KKYTCTVCGYIYNPEDGDPDNGVNPGTDFKDIPDDWVCPL CGVGKDQFEEVEEDKLERLMVKIGVFSVLYTVPATIVIAC YFYEISNWALFRYSADDSNMAVEMLKIFMSLLVGITSGMW IWSAKTLHTWQKFYNRLVN Description Functional site 1) chain A residue 1006 type sequence C description binding site for residue ZN A 1101 source : AC1 2) chain A residue 1009 type sequence C description binding site for residue ZN A 1101 source : AC1 3) chain A residue 1039 type sequence C description binding site for residue ZN A 1101 source : AC1 4) chain A residue 1042 type sequence C description binding site for residue ZN A 1101 source : AC1 5) chain A residue 440 type sequence F description binding site for residue OLC A 1102 source : AC2 6) chain A residue 443 type sequence L description binding site for residue OLC A 1102 source : AC2 7) chain A residue 444 type sequence Y description binding site for residue OLC A 1102 source : AC2 8) chain A residue 486 type sequence L description binding site for residue OLC A 1102 source : AC2 9) chain A residue 490 type sequence T description binding site for residue OLC A 1102 source : AC2 10) chain A residue 494 type sequence W description binding site for residue OLC A 1102 source : AC2 11) chain A residue 214 type sequence S description binding site for residue OLC A 1103 source : AC3 12) chain A residue 218 type sequence F description binding site for residue OLC A 1103 source : AC3 13) chain A residue 222 type sequence W description binding site for residue OLC A 1103 source : AC3 14) chain A residue 471 type sequence D description binding site for residue OLC A 1103 source : AC3 15) chain A residue 474 type sequence M description binding site for residue OLC A 1103 source : AC3 16) chain A residue 482 type sequence F description binding site for residue OLC A 1103 source : AC3 17) chain A residue 250 type sequence Y description binding site for residue OLC A 1104 source : AC4 18) chain A residue 253 type sequence R description binding site for residue OLC A 1104 source : AC4 19) chain A residue 344 type sequence S description binding site for residue OLC A 1104 source : AC4 20) chain A residue 345 type sequence S description binding site for residue OLC A 1104 source : AC4 21) chain A residue 348 type sequence H description binding site for residue OLC A 1104 source : AC4 22) chain A residue 352 type sequence W description binding site for residue OLC A 1104 source : AC4 23) chain A residue 275 type sequence V description binding site for residue OLC A 1105 source : AC5 24) chain A residue 299 type sequence N description binding site for residue OLC A 1105 source : AC5 25) chain A residue 300 type sequence T description binding site for residue OLC A 1105 source : AC5 26) chain A residue 301 type sequence G description binding site for residue OLC A 1105 source : AC5 27) chain A residue 321 type sequence V description binding site for residue OLA A 1106 source : AC6 28) chain A residue 343 type sequence H description binding site for residue OLA A 1106 source : AC6 29) chain A residue 347 type sequence F description binding site for residue OLA A 1106 source : AC6 30) chain A residue 398 type sequence Y description binding site for residue OLA A 1106 source : AC6 31) chain A residue 401 type sequence I description binding site for residue OLA A 1106 source : AC6 32) chain A residue 343 type sequence H description binding site for residue OLA A 1107 source : AC7 33) chain A residue 346 type sequence Y description binding site for residue OLA A 1107 source : AC7 34) chain A residue 349 type sequence I description binding site for residue OLA A 1107 source : AC7 35) chain A residue 350 type sequence A description binding site for residue OLA A 1107 source : AC7 36) chain A residue 392 type sequence V description binding site for residue OLA A 1108 source : AC8 37) chain A residue 396 type sequence F description binding site for residue OLA A 1108 source : AC8 38) chain A residue 399 type sequence L description binding site for residue OLA A 1108 source : AC8 39) chain A residue 403 type sequence T description binding site for residue OLA A 1108 source : AC8 40) chain A residue 407 type sequence A description binding site for residue OLA A 1108 source : AC8 41) chain A residue 445 type sequence T description binding site for residue OLA A 1108 source : AC8 42) chain A residue 449 type sequence T description binding site for residue OLA A 1108 source : AC8 43) chain A residue 231 type sequence F description binding site for residue OLA A 1109 source : AC9 44) chain A residue 263 type sequence N description binding site for residue OLA A 1109 source : AC9 45) chain A residue 300 type sequence T description binding site for residue OLA A 1110 source : AD1 46) chain A residue 307 type sequence L description binding site for residue OLA A 1110 source : AD1 47) chain A residue 364 type sequence I description binding site for residue OLA A 1110 source : AD1 48) chain A residue 384 type sequence L description binding site for residue SO4 A 1111 source : AD2 49) chain A residue 414 type sequence F description binding site for residue SO4 A 1111 source : AD2 50) chain A residue 382 type sequence Q description binding site for residue SO4 A 1112 source : AD3 51) chain A residue 383 type sequence N description binding site for residue SO4 A 1112 source : AD3 52) chain A residue 384 type sequence L description binding site for residue SO4 A 1112 source : AD3 53) chain A residue 417 type sequence R description binding site for residue SO4 A 1112 source : AD3 54) chain A residue 462 type sequence W description binding site for residue SO4 A 1112 source : AD3 55) chain A residue 466 type sequence R description binding site for residue SO4 A 1112 source : AD3 56) chain A residue 242 type sequence L description binding site for residue SO4 A 1113 source : AD4 57) chain A residue 345 type sequence S description binding site for residue SO4 A 1113 source : AD4 58) chain A residue 346 type sequence Y description binding site for residue SO4 A 1113 source : AD4 59) chain A residue 1006 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00241, ECO:0000269|PubMed:10216292 source Swiss-Prot : SWS_FT_FI10 60) chain A residue 1009 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00241, ECO:0000269|PubMed:10216292 source Swiss-Prot : SWS_FT_FI10 61) chain A residue 1039 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00241, ECO:0000269|PubMed:10216292 source Swiss-Prot : SWS_FT_FI10 62) chain A residue 1042 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00241, ECO:0000269|PubMed:10216292 source Swiss-Prot : SWS_FT_FI10 63) chain A residue 213-243 type TRANSMEM sequence RSAKEFTDIWMAVWASLCFISTAFTVLTFLI description Helical; Name=1 => ECO:0000269|PubMed:30135577 source Swiss-Prot : SWS_FT_FI1 64) chain A residue 1001 type MOD_RES sequence M description N-formylmethionine => ECO:0000269|PubMed:1637309 source Swiss-Prot : SWS_FT_FI11 65) chain A residue 244-249 type TOPO_DOM sequence DSSRFS description Cytoplasmic => ECO:0000269|PubMed:30135577 source Swiss-Prot : SWS_FT_FI2 66) chain A residue 334-336 type TOPO_DOM sequence KWG description Cytoplasmic => ECO:0000269|PubMed:30135577 source Swiss-Prot : SWS_FT_FI2 67) chain A residue 250-275 type TRANSMEM sequence YPERPIIFLSMCYNIYSIAYIVRLTV description Helical; Name=2 => ECO:0000269|PubMed:30135577 source Swiss-Prot : SWS_FT_FI3 68) chain A residue 276-299 type TOPO_DOM sequence GRERISCDFEEAAEPVLIQEGLKN description Extracellular => ECO:0000269|PubMed:30135577 source Swiss-Prot : SWS_FT_FI4 69) chain A residue 366-383 type TOPO_DOM sequence RLVDADELTGLCYVGNQN description Extracellular => ECO:0000269|PubMed:30135577 source Swiss-Prot : SWS_FT_FI4 70) chain A residue 461-473 type TOPO_DOM sequence NWALFRYSADDSN description Extracellular => ECO:0000269|PubMed:30135577 source Swiss-Prot : SWS_FT_FI4 71) chain A residue 300-333 type TRANSMEM sequence TGCAIIFLLLYFFGMASSIWWVILTLTWFLAAGL description Helical; Name=3 => ECO:0000269|PubMed:30135577 source Swiss-Prot : SWS_FT_FI5 72) chain A residue 337-365 type TRANSMEM sequence HEAIEMHSSYFHIAAWAIPAVKTIVILIM description Helical; Name=4 => ECO:0000269|PubMed:30135577 source Swiss-Prot : SWS_FT_FI6 73) chain A residue 384-418 type TRANSMEM sequence LDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRS description Helical; Name=5 => ECO:0000269|PubMed:30135577 source Swiss-Prot : SWS_FT_FI7 74) chain A residue 432-460 type TRANSMEM sequence RLMVKIGVFSVLYTVPATIVIACYFYEIS description Helical; Name=6 => ECO:0000269|PubMed:30135577 source Swiss-Prot : SWS_FT_FI8 75) chain A residue 1033-1043 type prosite sequence IPDDWVCPLCG description RUBREDOXIN Rubredoxin signature. IpDDWvCPlCG source prosite : PS00202 76) chain A residue 474-495 type TRANSMEM sequence MAVEMLKIFMSLLVGITSGMWI description Helical; Name=7 => ECO:0000269|PubMed:30135577 source Swiss-Prot : SWS_FT_FI9

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