|
eF-site ID
|
6b6b-A |
PDB Code
|
6b6b |
Chain
|
A |
|
click to enlarge
|
|
Title
|
Beta-Lactamase, unmixed needles crystal form |
Classification
|
HYDROLASE |
Compound
|
Beta-lactamase |
Source
|
(BLAC_MYCTU) |
|
Sequence
|
A: |
DLADRFAELERRYDARLGVYVPATGTTAAIEYRADERFAF
CSTFKAPLVAAVLHQNPLTHLDKLITYTSDDIRSISPVAQ
QHVQTGMTIGQLCDAAIRYSDGTAANLLLADLGGPGGGTA
AFTGYLRSLGDTVSRLDAEEPELNRDPPGDERDTTTPHAI
ALVLQQLVLGNALPPDKRALLTDWMARNTTGAKRIRAGFP
ADWKVIDKTGTGDYGRANDIAVVWSPTGVPYVVAVMSDRA
GGGYDAEPREALLAEAATCVAGVLA
|
|
Description
|
|
Functional site
|
|
1)
|
chain |
A |
residue |
66-81 |
type |
prosite |
sequence |
FAFCSTFKAPLVAAVL
|
description |
BETA_LACTAMASE_A Beta-lactamase class-A active site. FaFCSTfKaplVAAVL
|
source |
prosite : PS00146
|
|
2)
|
chain |
A |
residue |
70 |
type |
ACT_SITE |
sequence |
S
|
description |
Acyl-ester intermediate => ECO:0000269|PubMed:19251630, ECO:0000269|PubMed:20353175, ECO:0000269|PubMed:20961112
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
3)
|
chain |
A |
residue |
168 |
type |
ACT_SITE |
sequence |
E
|
description |
Proton acceptor => ECO:0000303|PubMed:20353175, ECO:0000303|PubMed:20961112
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
4)
|
chain |
A |
residue |
128 |
type |
BINDING |
sequence |
S
|
description |
BINDING => ECO:0000269|PubMed:19251630, ECO:0000269|PubMed:20353175, ECO:0000269|PubMed:20961112
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
5)
|
chain |
A |
residue |
237 |
type |
BINDING |
sequence |
T
|
description |
BINDING => ECO:0000269|PubMed:19251630, ECO:0000269|PubMed:20353175, ECO:0000269|PubMed:20961112
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
6)
|
chain |
A |
residue |
73 |
type |
SITE |
sequence |
K
|
description |
Increases nucleophilicity of active site Ser => ECO:0000303|PubMed:20353175, ECO:0000303|PubMed:20961112
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
7)
|
chain |
A |
residue |
103 |
type |
SITE |
sequence |
I
|
description |
Functions as a gatekeeper residue that regulates substrate accessibility to the enzyme active site => ECO:0000303|PubMed:24023821
|
source |
Swiss-Prot : SWS_FT_FI5
|
|
|
|