eF-site ID 6b6a-A
PDB Code 6b6a
Chain A

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Title Beta-Lactamase, 2secs timepoint, mixed, shards crystal form
Classification HYDROLASE/ANTIBIOTIC
Compound Beta-lactamase
Source (BLAC_MYCTU)
Sequence A:  DLADRFAELERRYDARLGVYVPATGTTAAIEYRADERFAF
CSTFKAPLVAAVLHQNPLTHLDKLITYTSDDIRSISPVAQ
QHVQTGMTIGQLCDAAIRYSDGTAANLLLADLGGPGGGTA
AFTGYLRSLGDTVSRLDAEEPELNRDPPGDERDTTTPHAI
ALVLQQLVLGNALPPDKRALLTDWMARNTTGAKRIRAGFP
ADWKVIDKTGTGDYGRANDIAVVWSPTGVPYVVAVMSDRA
GGGYDAEPREALLAEAATCVAGVLA
Description (1)  Beta-lactamase (E.C.3.5.2.6)


Functional site

1) chain A
residue 70
type
sequence S
description binding site for residue PO4 A 301
source : AC1

2) chain A
residue 128
type
sequence S
description binding site for residue PO4 A 301
source : AC1

3) chain A
residue 236
type
sequence K
description binding site for residue PO4 A 301
source : AC1

4) chain A
residue 237
type
sequence T
description binding site for residue PO4 A 301
source : AC1

5) chain A
residue 238
type
sequence G
description binding site for residue PO4 A 301
source : AC1

6) chain A
residue 239
type
sequence T
description binding site for residue PO4 A 301
source : AC1

7) chain A
residue 126
type
sequence R
description binding site for residue 9F2 A 302
source : AC2

8) chain A
residue 127
type
sequence Y
description binding site for residue 9F2 A 302
source : AC2

9) chain A
residue 216
type
sequence N
description binding site for residue 9F2 A 302
source : AC2

10) chain A
residue 217
type
sequence T
description binding site for residue 9F2 A 302
source : AC2

11) chain A
residue 109
type
sequence Q
description binding site for residue 9F2 B 301
source : AC3

12) chain A
residue 109
type
sequence Q
description binding site for residue FZS B 302
source : AC4

13) chain A
residue 70
type ACT_SITE
sequence S
description Acyl-ester intermediate => ECO:0000269|PubMed:19251630, ECO:0000269|PubMed:20353175, ECO:0000269|PubMed:20961112
source Swiss-Prot : SWS_FT_FI1

14) chain A
residue 66-81
type prosite
sequence FAFCSTFKAPLVAAVL
description BETA_LACTAMASE_A Beta-lactamase class-A active site. FaFCSTfKaplVAAVL
source prosite : PS00146

15) chain A
residue 168
type ACT_SITE
sequence E
description Proton acceptor => ECO:0000303|PubMed:20353175, ECO:0000303|PubMed:20961112
source Swiss-Prot : SWS_FT_FI2

16) chain A
residue 73
type SITE
sequence K
description Increases nucleophilicity of active site Ser => ECO:0000303|PubMed:20353175, ECO:0000303|PubMed:20961112
source Swiss-Prot : SWS_FT_FI4

17) chain A
residue 103
type SITE
sequence I
description Functions as a gatekeeper residue that regulates substrate accessibility to the enzyme active site => ECO:0000303|PubMed:24023821
source Swiss-Prot : SWS_FT_FI5

18) chain A
residue 128
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:19251630, ECO:0000269|PubMed:20353175, ECO:0000269|PubMed:20961112
source Swiss-Prot : SWS_FT_FI3

19) chain A
residue 237
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:19251630, ECO:0000269|PubMed:20353175, ECO:0000269|PubMed:20961112
source Swiss-Prot : SWS_FT_FI3


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