eF-site ID 6b5y-D PDB Code 6b5y Chain D click to enlarge Title Beta-lactamase, mixed with Ceftriaxone, 30ms time point, Shards crystal form Classification HYDROLASE Compound Beta-lactamase Source (BLAC_MYCTU) Sequence D:  DLADRFAELERRYDARLGVYVPATGTTAAIEYRADERFAF CSTFKAPLVAAVLHQNPLTHLDKLITYTSDDIRSISPVAQ QHVQTGMTIGQLCDAAIRYSDGTAANLLLADLGGPGGGTA AFTGYLRSLGDTVSRLDAEEPELNRDPPGDERDTTTPHAI ALVLQQLVLGNALPPDKRALLTDWMARNTTGAKRIRAGFP ADWKVIDKTGTGDYGRANDIAVVWSPTGVPYVVAVMSDRA GGGYDAEPREALLAEAATCVAGVLA Description Functional site 1) chain D residue 109 type sequence Q description binding site for residue PO4 C 301 source : AC4 2) chain D residue 127 type sequence Y description binding site for residue 9F2 C 302 source : AC5 3) chain D residue 217 type sequence T description binding site for residue 9F2 C 302 source : AC5 4) chain D residue 218 type sequence T description binding site for residue 9F2 C 302 source : AC5 5) chain D residue 241 type sequence D description binding site for residue 9F2 C 302 source : AC5 6) chain D residue 70 type sequence S description binding site for residue 9F2 D 400 source : AC6 7) chain D residue 128 type sequence S description binding site for residue 9F2 D 400 source : AC6 8) chain D residue 169 type sequence P description binding site for residue 9F2 D 400 source : AC6 9) chain D residue 172 type sequence N description binding site for residue 9F2 D 400 source : AC6 10) chain D residue 218 type sequence T description binding site for residue 9F2 D 400 source : AC6 11) chain D residue 236 type sequence K description binding site for residue 9F2 D 400 source : AC6 12) chain D residue 237 type sequence T description binding site for residue 9F2 D 400 source : AC6 13) chain D residue 238 type sequence G description binding site for residue 9F2 D 400 source : AC6 14) chain D residue 239 type sequence T description binding site for residue 9F2 D 400 source : AC6 15) chain D residue 240 type sequence G description binding site for residue 9F2 D 400 source : AC6 16) chain D residue 241 type sequence D description binding site for residue 9F2 D 400 source : AC6 17) chain D residue 70 type ACT_SITE sequence S description Acyl-ester intermediate => ECO:0000269|PubMed:19251630, ECO:0000269|PubMed:20353175, ECO:0000269|PubMed:20961112 source Swiss-Prot : SWS_FT_FI1 18) chain D residue 168 type ACT_SITE sequence E description Proton acceptor => ECO:0000303|PubMed:20353175, ECO:0000303|PubMed:20961112 source Swiss-Prot : SWS_FT_FI2 19) chain D residue 73 type SITE sequence K description Increases nucleophilicity of active site Ser => ECO:0000303|PubMed:20353175, ECO:0000303|PubMed:20961112 source Swiss-Prot : SWS_FT_FI4 20) chain D residue 103 type SITE sequence I description Functions as a gatekeeper residue that regulates substrate accessibility to the enzyme active site => ECO:0000303|PubMed:24023821 source Swiss-Prot : SWS_FT_FI5 21) chain D residue 128 type BINDING sequence S description BINDING => ECO:0000269|PubMed:19251630, ECO:0000269|PubMed:20353175, ECO:0000269|PubMed:20961112 source Swiss-Prot : SWS_FT_FI3 22) chain D residue 237 type BINDING sequence T description BINDING => ECO:0000269|PubMed:19251630, ECO:0000269|PubMed:20353175, ECO:0000269|PubMed:20961112 source Swiss-Prot : SWS_FT_FI3

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