eF-site ID 6b3j-R PDB Code 6b3j Chain R click to enlarge Title 3.3 angstrom phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex Classification SIGNALING PROTEIN Compound Glucagon-like peptide 1 receptor Source (6B3J) Sequence R:  VSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEY ACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGL WLQKDNSSLPWRDLSECEEPEEQLLFLYIIYTVGYALSFS ALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIK DAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCV AANYYWLLVEGVYLYTLLAFSVFSEQWIFRLYVSIGWGVP LLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAI GVNFLIFVRVICIVVSKLKADIKCRLAKSTLTLIPLLGTH EVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYC FVNNEVQLEFRKSWERWRLE Description (1)  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Nanobody 35, Calcitonin receptor Functional site 1) chain R residue 62-86 type prosite sequence CNRTFDEYACWPDGEPGSFVNVSCP description G_PROTEIN_RECEP_F2_1 G-protein coupled receptors family 2 signature 1. CnrtFDeya.CWpdGepgsfvnvsCP source prosite : PS00649 2) chain R residue 394-409 type prosite sequence QGLMVAILYCFVNNEV description G_PROTEIN_RECEP_F2_2 G-protein coupled receptors family 2 signature 2. QGLMVaILYCFvNneV source prosite : PS00650 3) chain R residue 252-265 type LIPID sequence YTLLAFSVFSEQWI description S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P63212 source Swiss-Prot : SWS_FT_FI3 4) chain R residue 329-348 type LIPID sequence CIVVSKLKADIKCR description S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P63212 source Swiss-Prot : SWS_FT_FI3 5) chain R residue 306-328 type TRANSMEM sequence WLIIRLPILFAIGVNFLIFVRVI description Helical; Name=5 => ECO:0000269|PubMed:28514449 source Swiss-Prot : SWS_FT_FI7 6) chain R residue 349-370 type TRANSMEM sequence LAKSTLTLIPLLGTHEVIFAFV description Helical; Name=6 => ECO:0000269|PubMed:28514449 source Swiss-Prot : SWS_FT_FI8 7) chain R residue 384-404 type TRANSMEM sequence LFTELSFTSFQGLMVAILYCF description Helical; Name=7 => ECO:0000269|PubMed:28514449 source Swiss-Prot : SWS_FT_FI9 8) chain R residue 121 type SITE sequence R description Interaction with the endogenous ligand GLP-1 => ECO:0000269|PubMed:19861722 source Swiss-Prot : SWS_FT_FI10 9) chain R residue 128 type SITE sequence E description Interaction with the endogenous ligand GLP-1 => ECO:0000269|PubMed:19861722 source Swiss-Prot : SWS_FT_FI10 10) chain R residue 348 type MOD_RES sequence R description ADP-ribosylarginine => ECO:0000269|PubMed:21901419 source Swiss-Prot : SWS_FT_FI12 11) chain R residue 63 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22412906 source Swiss-Prot : SWS_FT_FI13 12) chain R residue 82 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22412906 source Swiss-Prot : SWS_FT_FI13 13) chain R residue 115 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22412906 source Swiss-Prot : SWS_FT_FI13

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