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eF-site ID
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6b3j-B |
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PDB Code
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6b3j |
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Chain
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B |
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click to enlarge
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Title
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3.3 angstrom phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex |
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Classification
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SIGNALING PROTEIN |
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Compound
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Glucagon-like peptide 1 receptor |
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Source
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(6B3J) |
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Sequence
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B: |
ELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGR
IQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIW
DSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICS
IYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSG
DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSG
ACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFA
TGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSG
RLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTD
DGMAVATGSWDSFLKIWN
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Description
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(1) |
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Nanobody 35, Calcitonin receptor
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Functional site
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1)
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chain |
B |
| residue |
70-84 |
| type |
prosite |
| sequence |
LVSASQDGKLIIWDS
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| description |
WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
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| source |
prosite : PS00678
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2)
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chain |
B |
| residue |
157-171 |
| type |
prosite |
| sequence |
IVTSSGDTTCALWDI
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| description |
WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
|
| source |
prosite : PS00678
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3)
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chain |
B |
| residue |
285-299 |
| type |
prosite |
| sequence |
LLAGYDDFNCNVWDA
|
| description |
WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
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| source |
prosite : PS00678
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