eF-site ID 6b3j-ABGNPR
PDB Code 6b3j
Chain A, B, G, N, P, R

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Title 3.3 angstrom phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex
Classification SIGNALING PROTEIN
Compound Glucagon-like peptide 1 receptor
Source (6B3J)
Sequence A:  DQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGSGI
FETKFQVDKVNFHMFDVGAQRDERRKWIQCFNDVTAIIFV
VANRLQAALKLFDSIWNNKWLRDTSVILFLNKQDIEDYFP
EFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASG
DGRHYCYPHFTNIRRVFNDCRDIIQRMHLRQYELL
B:  ELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGR
IQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIW
DSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICS
IYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSG
DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSG
ACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFA
TGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSG
RLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTD
DGMAVATGSWDSFLKIWN
G:  TASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHA
KEDPLLTPVPASENPFR
N:  QVQLQESGGGLVQPGGSLRLSCAASGFTFSNYKMNWVRQA
PGKGLEWVSDISQSGASISYTGSVKGRFTISRDNAKNTLY
LQMNSLKPEDTAVYYCARCPAPFTRDCFDVTSTTYAYRGQ
GTQVTV
P:  ELVDNAVGGDLSKQMEEEAVRLFIEWLKNGGPS
R:  VSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEY
ACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGL
WLQKDNSSLPWRDLSECEEPEEQLLFLYIIYTVGYALSFS
ALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIK
DAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCV
AANYYWLLVEGVYLYTLLAFSVFSEQWIFRLYVSIGWGVP
LLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAI
GVNFLIFVRVICIVVSKLKADIKCRLAKSTLTLIPLLGTH
EVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYC
FVNNEVQLEFRKSWERWRLE
Description (1)  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Nanobody 35, Calcitonin receptor


Functional site

1) chain A
residue 223
type MOD_RES
sequence D
description N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378
source Swiss-Prot : SWS_FT_FI1

2) chain A
residue 292
type MOD_RES
sequence N
description N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378
source Swiss-Prot : SWS_FT_FI1

3) chain R
residue 121
type SITE
sequence R
description Interaction with the endogenous ligand GLP-1 => ECO:0000269|PubMed:19861722
source Swiss-Prot : SWS_FT_FI10

4) chain R
residue 128
type SITE
sequence E
description Interaction with the endogenous ligand GLP-1 => ECO:0000269|PubMed:19861722
source Swiss-Prot : SWS_FT_FI10

5) chain R
residue 306-328
type TRANSMEM
sequence WLIIRLPILFAIGVNFLIFVRVI
description Helical; Name=5 => ECO:0000269|PubMed:28514449
source Swiss-Prot : SWS_FT_FI7

6) chain B
residue 70-84
type prosite
sequence LVSASQDGKLIIWDS
description WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
source prosite : PS00678

7) chain B
residue 157-171
type prosite
sequence IVTSSGDTTCALWDI
description WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
source prosite : PS00678

8) chain B
residue 285-299
type prosite
sequence LLAGYDDFNCNVWDA
description WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
source prosite : PS00678

9) chain R
residue 62-86
type prosite
sequence CNRTFDEYACWPDGEPGSFVNVSCP
description G_PROTEIN_RECEP_F2_1 G-protein coupled receptors family 2 signature 1. CnrtFDeya.CWpdGepgsfvnvsCP
source prosite : PS00649

10) chain R
residue 394-409
type prosite
sequence QGLMVAILYCFVNNEV
description G_PROTEIN_RECEP_F2_2 G-protein coupled receptors family 2 signature 2. QGLMVaILYCFvNneV
source prosite : PS00650

11) chain R
residue 252-265
type LIPID
sequence YTLLAFSVFSEQWI
description S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P63212
source Swiss-Prot : SWS_FT_FI3

12) chain R
residue 329-348
type LIPID
sequence CIVVSKLKADIKCR
description S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P63212
source Swiss-Prot : SWS_FT_FI3

13) chain R
residue 348
type MOD_RES
sequence R
description ADP-ribosylarginine => ECO:0000269|PubMed:21901419
source Swiss-Prot : SWS_FT_FI12

14) chain R
residue 63
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22412906
source Swiss-Prot : SWS_FT_FI13

15) chain R
residue 82
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22412906
source Swiss-Prot : SWS_FT_FI13

16) chain R
residue 115
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22412906
source Swiss-Prot : SWS_FT_FI13

17) chain R
residue 384-404
type TRANSMEM
sequence LFTELSFTSFQGLMVAILYCF
description Helical; Name=7 => ECO:0000269|PubMed:28514449
source Swiss-Prot : SWS_FT_FI9

18) chain R
residue 349-370
type TRANSMEM
sequence LAKSTLTLIPLLGTHEVIFAFV
description Helical; Name=6 => ECO:0000269|PubMed:28514449
source Swiss-Prot : SWS_FT_FI8


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