eF-site ID 6b3f-B PDB Code 6b3f Chain B click to enlarge Title Crystal Structure of HIV Protease complexed with N-(3-fluoro-2-(2-((2S,5S)-5-methyl-1-(phenylsulfonyl)piperazin-2-yl)ethyl)phenyl)-3,3-bis(4-fluorophenyl)propanamide Classification VIRAL PROTEIN/INHIBITOR Compound HIV-1 Protease Source Human immunodeficiency virus type 1 group M subtype B (isolate BH5) (HIV-1) (POL_HV1B5) Sequence B:  PQITLWKRPLVTIKIGGQLKEALLDTGADDTVIEEMSLPG RWKPKMIGGIGGFIKVRQYDQIIIEICGHKAIGTVLVGPT PVNIIGRNLLTQIGCTLNF Description Functional site 1) chain B residue 41 type sequence R description binding site for residue CL A 101 source : AC1 2) chain B residue 23 type sequence L description binding site for residue CKV B 101 source : AC2 3) chain B residue 25 type sequence D description binding site for residue CKV B 101 source : AC2 4) chain B residue 27 type sequence G description binding site for residue CKV B 101 source : AC2 5) chain B residue 28 type sequence A description binding site for residue CKV B 101 source : AC2 6) chain B residue 29 type sequence D description binding site for residue CKV B 101 source : AC2 7) chain B residue 30 type sequence D description binding site for residue CKV B 101 source : AC2 8) chain B residue 48 type sequence G description binding site for residue CKV B 101 source : AC2 9) chain B residue 49 type sequence G description binding site for residue CKV B 101 source : AC2 10) chain B residue 50 type sequence I description binding site for residue CKV B 101 source : AC2 11) chain B residue 84 type sequence I description binding site for residue CKV B 101 source : AC2 12) chain B residue 74 type sequence T description binding site for residue CL B 102 source : AC3 13) chain B residue 88 type sequence N description binding site for residue CL B 102 source : AC3 14) chain B residue 6 type sequence W description binding site for residue CL B 103 source : AC4 15) chain B residue 25 type ACT_SITE sequence D description For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094 source Swiss-Prot : SWS_FT_FI1 16) chain B residue 99 type SITE sequence F description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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