eF-site ID 6b3f-AB PDB Code 6b3f Chain A, B click to enlarge Title Crystal Structure of HIV Protease complexed with N-(3-fluoro-2-(2-((2S,5S)-5-methyl-1-(phenylsulfonyl)piperazin-2-yl)ethyl)phenyl)-3,3-bis(4-fluorophenyl)propanamide Classification VIRAL PROTEIN/INHIBITOR Compound HIV-1 Protease Source Human immunodeficiency virus type 1 group M subtype B (isolate BH5) (HIV-1) (POL_HV1B5) Sequence A:  PQITLWKRPLVTIKIGGQLKEALLDTGADDTVIEEMSLPG RWKPKMIGGIGGFIKVRQYDQIIIEICGHKAIGTVLVGPT PVNIIGRNLLTQIGCTLNF B:  PQITLWKRPLVTIKIGGQLKEALLDTGADDTVIEEMSLPG RWKPKMIGGIGGFIKVRQYDQIIIEICGHKAIGTVLVGPT PVNIIGRNLLTQIGCTLNF Description Functional site 1) chain A residue 74 type sequence T description binding site for residue CL A 101 source : AC1 2) chain A residue 88 type sequence N description binding site for residue CL A 101 source : AC1 3) chain B residue 41 type sequence R description binding site for residue CL A 101 source : AC1 4) chain A residue 8 type sequence R description binding site for residue CKV B 101 source : AC2 5) chain A residue 25 type sequence D description binding site for residue CKV B 101 source : AC2 6) chain A residue 27 type sequence G description binding site for residue CKV B 101 source : AC2 7) chain A residue 48 type sequence G description binding site for residue CKV B 101 source : AC2 8) chain A residue 49 type sequence G description binding site for residue CKV B 101 source : AC2 9) chain A residue 50 type sequence I description binding site for residue CKV B 101 source : AC2 10) chain A residue 82 type sequence V description binding site for residue CKV B 101 source : AC2 11) chain A residue 84 type sequence I description binding site for residue CKV B 101 source : AC2 12) chain B residue 23 type sequence L description binding site for residue CKV B 101 source : AC2 13) chain B residue 25 type sequence D description binding site for residue CKV B 101 source : AC2 14) chain B residue 27 type sequence G description binding site for residue CKV B 101 source : AC2 15) chain B residue 28 type sequence A description binding site for residue CKV B 101 source : AC2 16) chain B residue 29 type sequence D description binding site for residue CKV B 101 source : AC2 17) chain B residue 30 type sequence D description binding site for residue CKV B 101 source : AC2 18) chain B residue 48 type sequence G description binding site for residue CKV B 101 source : AC2 19) chain B residue 49 type sequence G description binding site for residue CKV B 101 source : AC2 20) chain B residue 50 type sequence I description binding site for residue CKV B 101 source : AC2 21) chain B residue 84 type sequence I description binding site for residue CKV B 101 source : AC2 22) chain B residue 74 type sequence T description binding site for residue CL B 102 source : AC3 23) chain B residue 88 type sequence N description binding site for residue CL B 102 source : AC3 24) chain B residue 6 type sequence W description binding site for residue CL B 103 source : AC4 25) chain A residue 22-33 type prosite sequence ALLDTGADDTVI description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVI source prosite : PS00141 26) chain A residue 25 type ACT_SITE sequence D description For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094 source Swiss-Prot : SWS_FT_FI1 27) chain B residue 25 type ACT_SITE sequence D description For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094 source Swiss-Prot : SWS_FT_FI1 28) chain A residue 99 type SITE sequence F description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 29) chain B residue 99 type SITE sequence F description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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