eF-site ID 6b1c-A
PDB Code 6b1c
Chain A

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Title Macrophage Migration Inhibitory Factor in complex with a Naphthyridinone Inhibitor (4a)
Classification ISOMERASE/ISOMERASE inhibitor
Compound Macrophage migration inhibitory factor
Source (MIF_HUMAN)
Sequence A:  PMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVH
VVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLC
GLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
Description


Functional site

1) chain A
residue 68
type
sequence G
description binding site for residue SO4 A 201
source : AC1

2) chain A
residue 69
type
sequence G
description binding site for residue SO4 A 201
source : AC1

3) chain A
residue 70
type
sequence A
description binding site for residue SO4 A 201
source : AC1

4) chain A
residue 71
type
sequence Q
description binding site for residue SO4 A 201
source : AC1

5) chain A
residue 1
type
sequence P
description binding site for residue C9J A 202
source : AC2

6) chain A
residue 2
type
sequence M
description binding site for residue C9J A 202
source : AC2

7) chain A
residue 32
type
sequence K
description binding site for residue C9J A 202
source : AC2

8) chain A
residue 36
type
sequence Y
description binding site for residue C9J A 202
source : AC2

9) chain A
residue 62
type
sequence H
description binding site for residue C9J A 202
source : AC2

10) chain A
residue 63
type
sequence S
description binding site for residue C9J A 202
source : AC2

11) chain A
residue 64
type
sequence I
description binding site for residue C9J A 202
source : AC2

12) chain A
residue 101
type
sequence M
description binding site for residue C9J A 202
source : AC2

13) chain A
residue 106
type
sequence V
description binding site for residue C9J A 202
source : AC2

14) chain A
residue 95
type
sequence Y
description binding site for residue C9J B 201
source : AC3

15) chain A
residue 97
type
sequence N
description binding site for residue C9J B 201
source : AC3

16) chain A
residue 77
type
sequence K
description binding site for residue SO4 C 201
source : AC4

17) chain A
residue 73
type
sequence R
description binding site for residue SO4 C 203
source : AC6

18) chain A
residue 54-68
type prosite
sequence EPCALCSLHSIGKIG
description MIF Macrophage migration inhibitory factor family signature. EPCAlcsLhSIGkIG
source prosite : PS01158

19) chain A
residue 1
type ACT_SITE
sequence P
description Proton acceptor; via imino nitrogen => ECO:0000250|UniProtKB:P34884
source Swiss-Prot : SWS_FT_FI1

20) chain A
residue 32
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:11170644, ECO:0000269|PubMed:17526494, ECO:0000269|PubMed:19090677
source Swiss-Prot : SWS_FT_FI2

21) chain A
residue 64
type BINDING
sequence I
description BINDING => ECO:0000269|PubMed:11170644, ECO:0000269|PubMed:17526494, ECO:0000269|PubMed:19090677
source Swiss-Prot : SWS_FT_FI2

22) chain A
residue 97
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:11170644, ECO:0000269|PubMed:17526494, ECO:0000269|PubMed:19090677
source Swiss-Prot : SWS_FT_FI2

23) chain A
residue 77
type MOD_RES
sequence K
description N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P34884
source Swiss-Prot : SWS_FT_FI3


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