eF-site ID 6b1c-A PDB Code 6b1c Chain A click to enlarge Title Macrophage Migration Inhibitory Factor in complex with a Naphthyridinone Inhibitor (4a) Classification ISOMERASE/ISOMERASE inhibitor Compound Macrophage migration inhibitory factor Source (MIF_HUMAN) Sequence A:  PMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVH VVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLC GLLAERLRISPDRVYINYYDMNAANVGWNNSTFA Description Functional site 1) chain A residue 68 type sequence G description binding site for residue SO4 A 201 source : AC1 2) chain A residue 69 type sequence G description binding site for residue SO4 A 201 source : AC1 3) chain A residue 70 type sequence A description binding site for residue SO4 A 201 source : AC1 4) chain A residue 71 type sequence Q description binding site for residue SO4 A 201 source : AC1 5) chain A residue 1 type sequence P description binding site for residue C9J A 202 source : AC2 6) chain A residue 2 type sequence M description binding site for residue C9J A 202 source : AC2 7) chain A residue 32 type sequence K description binding site for residue C9J A 202 source : AC2 8) chain A residue 36 type sequence Y description binding site for residue C9J A 202 source : AC2 9) chain A residue 62 type sequence H description binding site for residue C9J A 202 source : AC2 10) chain A residue 63 type sequence S description binding site for residue C9J A 202 source : AC2 11) chain A residue 64 type sequence I description binding site for residue C9J A 202 source : AC2 12) chain A residue 101 type sequence M description binding site for residue C9J A 202 source : AC2 13) chain A residue 106 type sequence V description binding site for residue C9J A 202 source : AC2 14) chain A residue 95 type sequence Y description binding site for residue C9J B 201 source : AC3 15) chain A residue 97 type sequence N description binding site for residue C9J B 201 source : AC3 16) chain A residue 77 type sequence K description binding site for residue SO4 C 201 source : AC4 17) chain A residue 73 type sequence R description binding site for residue SO4 C 203 source : AC6 18) chain A residue 54-68 type prosite sequence EPCALCSLHSIGKIG description MIF Macrophage migration inhibitory factor family signature. EPCAlcsLhSIGkIG source prosite : PS01158 19) chain A residue 1 type ACT_SITE sequence P description Proton acceptor; via imino nitrogen => ECO:0000250|UniProtKB:P34884 source Swiss-Prot : SWS_FT_FI1 20) chain A residue 32 type BINDING sequence K description BINDING => ECO:0000269|PubMed:11170644, ECO:0000269|PubMed:17526494, ECO:0000269|PubMed:19090677 source Swiss-Prot : SWS_FT_FI2 21) chain A residue 64 type BINDING sequence I description BINDING => ECO:0000269|PubMed:11170644, ECO:0000269|PubMed:17526494, ECO:0000269|PubMed:19090677 source Swiss-Prot : SWS_FT_FI2 22) chain A residue 97 type BINDING sequence N description BINDING => ECO:0000269|PubMed:11170644, ECO:0000269|PubMed:17526494, ECO:0000269|PubMed:19090677 source Swiss-Prot : SWS_FT_FI2 23) chain A residue 77 type MOD_RES sequence K description N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P34884 source Swiss-Prot : SWS_FT_FI3

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