eF-site ID 6b09-AB PDB Code 6b09 Chain A, B click to enlarge Title Crystal structure of HsNUDT16 in complex with diADPR (soaked) Classification HYDROLASE Compound U8 snoRNA-decapping enzyme Source (NUD16_HUMAN) Sequence A:  GARRLELGEALALGWRHVCHALLYAPDPGMLFGRIPLRYA ILMQMRFDGRLGFPGGFVDTQDRSLEDGLNRELREELGEA AAAFRVERTDYRSSHVGSGPRVVAHFYAKRLTLEELLAVE AGATRAKDHGLEVLGLVRVPLYTLRDGVGGLPTFLENSFI GSAREQLLEALQDLGL B:  ARRLELGEALALGSGWRHVCHALLYAPDPGMLFGRIPLRY AILMQMRFDGRLGFPGGFVDTQDRSLEDGLNRELREELGE AAAAFRVERTDYRSSHVPRVVAHFYAKRLTLEELLAVEAG ATRAKDHGLEVLGLVRVPLYTLRDGVGGLPTFLENSFIGS AREQLLEALQDLGLL Description Functional site 1) chain A residue 20 type sequence R description binding site for residue C7G A 401 source : AC1 2) chain A residue 24 type sequence H description binding site for residue C7G A 401 source : AC1 3) chain A residue 50 type sequence R description binding site for residue C7G A 401 source : AC1 4) chain A residue 51 type sequence F description binding site for residue C7G A 401 source : AC1 5) chain A residue 60 type sequence G description binding site for residue C7G A 401 source : AC1 6) chain A residue 61 type sequence F description binding site for residue C7G A 401 source : AC1 7) chain A residue 76 type sequence E description binding site for residue C7G A 401 source : AC1 8) chain A residue 80 type sequence E description binding site for residue C7G A 401 source : AC1 9) chain A residue 136 type sequence E description binding site for residue C7G A 401 source : AC1 10) chain A residue 164 type sequence I description binding site for residue C7G A 401 source : AC1 11) chain A residue 166 type sequence S description binding site for residue C7G A 401 source : AC1 12) chain A residue 167 type sequence A description binding site for residue C7G A 401 source : AC1 13) chain A residue 170 type sequence Q description binding site for residue C7G A 401 source : AC1 14) chain B residue 38 type sequence R description binding site for residue C7G A 401 source : AC1 15) chain A residue 50 type sequence R description binding site for residue MG A 402 source : AC2 16) chain A residue 59 type sequence G description binding site for residue MG A 402 source : AC2 17) chain A residue 80 type sequence E description binding site for residue MG A 402 source : AC2 18) chain A residue 76 type sequence E description binding site for residue MG A 403 source : AC3 19) chain A residue 80 type sequence E description binding site for residue MG A 403 source : AC3 20) chain A residue 132 type sequence D description binding site for residue MG A 403 source : AC3 21) chain A residue 136 type sequence E description binding site for residue MG A 403 source : AC3 22) chain A residue 76 type sequence E description binding site for residue NA A 405 source : AC4 23) chain A residue 79 type sequence E description binding site for residue NA A 405 source : AC4 24) chain A residue 36 type sequence F description binding site for residue C7G B 401 source : AC5 25) chain A residue 149 type sequence R description binding site for residue C7G B 401 source : AC5 26) chain A residue 150 type sequence D description binding site for residue C7G B 401 source : AC5 27) chain A residue 169 type sequence E description binding site for residue C7G B 401 source : AC5 28) chain B residue 24 type sequence H description binding site for residue C7G B 401 source : AC5 29) chain B residue 50 type sequence R description binding site for residue C7G B 401 source : AC5 30) chain B residue 59 type sequence G description binding site for residue C7G B 401 source : AC5 31) chain B residue 60 type sequence G description binding site for residue C7G B 401 source : AC5 32) chain B residue 61 type sequence F description binding site for residue C7G B 401 source : AC5 33) chain B residue 76 type sequence E description binding site for residue C7G B 401 source : AC5 34) chain B residue 80 type sequence E description binding site for residue C7G B 401 source : AC5 35) chain B residue 108 type sequence A description binding site for residue C7G B 401 source : AC5 36) chain B residue 136 type sequence E description binding site for residue C7G B 401 source : AC5 37) chain B residue 164 type sequence I description binding site for residue C7G B 401 source : AC5 38) chain B residue 166 type sequence S description binding site for residue C7G B 401 source : AC5 39) chain B residue 167 type sequence A description binding site for residue C7G B 401 source : AC5 40) chain B residue 170 type sequence Q description binding site for residue C7G B 401 source : AC5 41) chain B residue 76 type sequence E description binding site for residue MG B 402 source : AC6 42) chain B residue 76 type sequence E description binding site for residue MG B 403 source : AC7 43) chain B residue 80 type sequence E description binding site for residue MG B 403 source : AC7 44) chain B residue 132 type sequence D description binding site for residue MG B 403 source : AC7 45) chain B residue 136 type sequence E description binding site for residue MG B 403 source : AC7 46) chain B residue 31 type sequence D description binding site for residue NA B 404 source : AC8 47) chain B residue 40 type sequence P description binding site for residue NA B 404 source : AC8 48) chain B residue 42 type sequence R description binding site for residue NA B 404 source : AC8 49) chain A residue 57 type BINDING sequence F description BINDING => ECO:0000305|PubMed:26121039 source Swiss-Prot : SWS_FT_FI1 50) chain A residue 170 type BINDING sequence Q description BINDING => ECO:0000305|PubMed:26121039 source Swiss-Prot : SWS_FT_FI1 51) chain B residue 24 type BINDING sequence H description BINDING => ECO:0000305|PubMed:26121039 source Swiss-Prot : SWS_FT_FI1 52) chain B residue 50 type BINDING sequence R description BINDING => ECO:0000305|PubMed:26121039 source Swiss-Prot : SWS_FT_FI1 53) chain B residue 57 type BINDING sequence F description BINDING => ECO:0000305|PubMed:26121039 source Swiss-Prot : SWS_FT_FI1 54) chain B residue 170 type BINDING sequence Q description BINDING => ECO:0000305|PubMed:26121039 source Swiss-Prot : SWS_FT_FI1 55) chain A residue 24 type BINDING sequence H description BINDING => ECO:0000305|PubMed:26121039 source Swiss-Prot : SWS_FT_FI1 56) chain A residue 50 type BINDING sequence R description BINDING => ECO:0000305|PubMed:26121039 source Swiss-Prot : SWS_FT_FI1 57) chain A residue 59 type BINDING sequence G description BINDING => ECO:0000269|PubMed:32432673, ECO:0000305|PubMed:26121039, ECO:0007744|PDB:6X7U source Swiss-Prot : SWS_FT_FI2 58) chain B residue 59 type BINDING sequence G description BINDING => ECO:0000269|PubMed:32432673, ECO:0000305|PubMed:26121039, ECO:0007744|PDB:6X7U source Swiss-Prot : SWS_FT_FI2 59) chain B residue 80 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:Q6TEC1 source Swiss-Prot : SWS_FT_FI3 60) chain A residue 76 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:Q6TEC1 source Swiss-Prot : SWS_FT_FI3 61) chain A residue 80 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:Q6TEC1 source Swiss-Prot : SWS_FT_FI3 62) chain B residue 76 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:Q6TEC1 source Swiss-Prot : SWS_FT_FI3 63) chain B residue 99 type BINDING sequence H description BINDING => ECO:0000269|PubMed:32432673, ECO:0007744|PDB:6X7U, ECO:0007744|PDB:6X7V source Swiss-Prot : SWS_FT_FI4 64) chain B residue 173 type BINDING sequence E description BINDING => ECO:0000269|PubMed:32432673, ECO:0007744|PDB:6X7U, ECO:0007744|PDB:6X7V source Swiss-Prot : SWS_FT_FI4 65) chain A residue 99 type BINDING sequence H description BINDING => ECO:0000269|PubMed:32432673, ECO:0007744|PDB:6X7U, ECO:0007744|PDB:6X7V source Swiss-Prot : SWS_FT_FI4 66) chain A residue 173 type BINDING sequence E description BINDING => ECO:0000269|PubMed:32432673, ECO:0007744|PDB:6X7U, ECO:0007744|PDB:6X7V source Swiss-Prot : SWS_FT_FI4

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