eF-site ID 6av6-D PDB Code 6av6 Chain D click to enlarge Title Structure of human endothelial nitric oxide synthase heme domain in complex with 6-(3-Fluoro-5-(3-(methylamino)propyl)phenethyl)-4-methylpyridin-2-amine Classification OXIDOREDUCTASE Compound Nitric oxide synthase, endothelial Source (NOS3_HUMAN) Sequence D:  KFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCLGSLVFP APEQLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVA ATGTYQLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDA RDCRSAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGR GDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHG WTPGNGRFDVLPLLLQAPDEPPELFLLPPELVLEVPLEHP TLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYM STEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKA AVEINVAVLHSYQLAKVTIVDHHAATASFMKHLENEQKAR GGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPD PW Description Functional site 1) chain D residue 325 type sequence A description binding site for residue BTB A 503 source : AC3 2) chain D residue 326 type sequence L description binding site for residue BTB A 503 source : AC3 3) chain D residue 378 type sequence D description binding site for residue BTB A 503 source : AC3 4) chain D residue 384 type sequence D description binding site for residue BTB A 504 source : AC4 5) chain D residue 167 type sequence E description binding site for residue BTB B 506 source : AD5 6) chain D residue 445 type sequence W description binding site for residue H4B C 502 source : AE2 7) chain D residue 460 type sequence F description binding site for residue H4B C 502 source : AE2 8) chain D residue 461 type sequence H description binding site for residue H4B C 502 source : AE2 9) chain D residue 463 type sequence E description binding site for residue H4B C 502 source : AE2 10) chain D residue 94 type sequence C description binding site for residue ZN C 505 source : AE5 11) chain D residue 99 type sequence C description binding site for residue ZN C 505 source : AE5 12) chain D residue 178 type sequence W description binding site for residue HEM D 501 source : AE9 13) chain D residue 183 type sequence R description binding site for residue HEM D 501 source : AE9 14) chain D residue 184 type sequence C description binding site for residue HEM D 501 source : AE9 15) chain D residue 185 type sequence V description binding site for residue HEM D 501 source : AE9 16) chain D residue 226 type sequence S description binding site for residue HEM D 501 source : AE9 17) chain D residue 353 type sequence F description binding site for residue HEM D 501 source : AE9 18) chain D residue 354 type sequence S description binding site for residue HEM D 501 source : AE9 19) chain D residue 356 type sequence W description binding site for residue HEM D 501 source : AE9 20) chain D residue 361 type sequence E description binding site for residue HEM D 501 source : AE9 21) chain D residue 447 type sequence W description binding site for residue HEM D 501 source : AE9 22) chain D residue 473 type sequence F description binding site for residue HEM D 501 source : AE9 23) chain D residue 475 type sequence Y description binding site for residue HEM D 501 source : AE9 24) chain D residue 102 type sequence S description binding site for residue H4B D 502 source : AF1 25) chain D residue 365 type sequence R description binding site for residue H4B D 502 source : AF1 26) chain D residue 446 type sequence A description binding site for residue H4B D 502 source : AF1 27) chain D residue 447 type sequence W description binding site for residue H4B D 502 source : AF1 28) chain D residue 105 type sequence F description binding site for residue W68 D 503 source : AF2 29) chain D residue 247 type sequence Q description binding site for residue W68 D 503 source : AF2 30) chain D residue 336 type sequence V description binding site for residue W68 D 503 source : AF2 31) chain D residue 353 type sequence F description binding site for residue W68 D 503 source : AF2 32) chain D residue 356 type sequence W description binding site for residue W68 D 503 source : AF2 33) chain D residue 361 type sequence E description binding site for residue W68 D 503 source : AF2 34) chain D residue 447 type sequence W description binding site for residue W68 D 503 source : AF2 35) chain D residue 319 type sequence T description binding site for residue BTB D 504 source : AF3 36) chain D residue 321 type sequence E description binding site for residue BTB D 504 source : AF3 37) chain D residue 297 type sequence D description binding site for residue BTB D 505 source : AF4 38) chain D residue 298 type sequence E description binding site for residue BTB D 505 source : AF4 39) chain D residue 319 type sequence T description binding site for residue GD D 506 source : AF5 40) chain D residue 321 type sequence E description binding site for residue GD D 506 source : AF5 41) chain D residue 247 type sequence Q description binding site for residue CL D 507 source : AF6 42) chain D residue 250 type sequence R description binding site for residue CL D 507 source : AF6 43) chain D residue 357 type sequence Y description binding site for residue CL D 507 source : AF6 44) chain D residue 366 type sequence N description binding site for residue CL D 507 source : AF6 45) chain D residue 184 type catalytic sequence C description 935 source MCSA : MCSA4 46) chain D residue 187 type catalytic sequence R description 935 source MCSA : MCSA4 47) chain D residue 356 type catalytic sequence W description 935 source MCSA : MCSA4 48) chain D residue 361 type catalytic sequence E description 935 source MCSA : MCSA4 49) chain D residue 102 type BINDING sequence S description BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1O source Swiss-Prot : SWS_FT_FI2 50) chain D residue 247 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1O source Swiss-Prot : SWS_FT_FI2 51) chain D residue 356 type BINDING sequence W description BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1O source Swiss-Prot : SWS_FT_FI2 52) chain D residue 357 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1O source Swiss-Prot : SWS_FT_FI2 53) chain D residue 361 type BINDING sequence E description BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1O source Swiss-Prot : SWS_FT_FI2 54) chain D residue 366 type BINDING sequence N description BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1O source Swiss-Prot : SWS_FT_FI2 55) chain D residue 446 type BINDING sequence A description BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1O source Swiss-Prot : SWS_FT_FI2 56) chain D residue 447 type BINDING sequence W description BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1O source Swiss-Prot : SWS_FT_FI2 57) chain D residue 460 type BINDING sequence F description BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1O source Swiss-Prot : SWS_FT_FI2 58) chain D residue 475 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1O source Swiss-Prot : SWS_FT_FI2 59) chain D residue 184 type BINDING sequence C description axial binding residue => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1O source Swiss-Prot : SWS_FT_FI3 60) chain D residue 365 type BINDING sequence R description BINDING => ECO:0000269|PubMed:10074942, ECO:0000269|PubMed:25286850, ECO:0007744|PDB:3NOS, ECO:0007744|PDB:4D1O, ECO:0007744|PDB:4D1P source Swiss-Prot : SWS_FT_FI4 61) chain D residue 94 type BINDING sequence C description BINDING => ECO:0000269|PubMed:10074942, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:18849972, ECO:0000269|PubMed:25286850, ECO:0007744|PDB:1M9J, ECO:0007744|PDB:1M9K, ECO:0007744|PDB:1M9M, ECO:0007744|PDB:1M9Q, ECO:0007744|PDB:1M9R, ECO:0007744|PDB:3EAH, ECO:0007744|PDB:3NOS, ECO:0007744|PDB:4D1O, ECO:0007744|PDB:4D1P source Swiss-Prot : SWS_FT_FI1 62) chain D residue 99 type BINDING sequence C description BINDING => ECO:0000269|PubMed:10074942, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:18849972, ECO:0000269|PubMed:25286850, ECO:0007744|PDB:1M9J, ECO:0007744|PDB:1M9K, ECO:0007744|PDB:1M9M, ECO:0007744|PDB:1M9Q, ECO:0007744|PDB:1M9R, ECO:0007744|PDB:3EAH, ECO:0007744|PDB:3NOS, ECO:0007744|PDB:4D1O, ECO:0007744|PDB:4D1P source Swiss-Prot : SWS_FT_FI1

Display surface Download Links