eF-site ID 6auu-A PDB Code 6auu Chain A click to enlarge Title Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(3-(3-(dimethylamino)propyl)-5-(trifluoromethyl)phenethyl)-4-methylpyridin-2-amine Classification OXIDOREDUCTASE Compound Nitric oxide synthase, brain Source (NOS1_RAT) Sequence A:  RFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLP DVRTKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNK EIESTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQV FDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRT DGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICI QQGWKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPI RHPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSG WYMGTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTSSLWK DQALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEY RCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEY QPDPWNTHVW Description Functional site 1) chain A residue 409 type sequence W description binding site for residue HEM A 801 source : AC1 2) chain A residue 415 type sequence C description binding site for residue HEM A 801 source : AC1 3) chain A residue 457 type sequence S description binding site for residue HEM A 801 source : AC1 4) chain A residue 584 type sequence F description binding site for residue HEM A 801 source : AC1 5) chain A residue 585 type sequence S description binding site for residue HEM A 801 source : AC1 6) chain A residue 587 type sequence W description binding site for residue HEM A 801 source : AC1 7) chain A residue 589 type sequence M description binding site for residue HEM A 801 source : AC1 8) chain A residue 592 type sequence E description binding site for residue HEM A 801 source : AC1 9) chain A residue 678 type sequence W description binding site for residue HEM A 801 source : AC1 10) chain A residue 704 type sequence F description binding site for residue HEM A 801 source : AC1 11) chain A residue 706 type sequence Y description binding site for residue HEM A 801 source : AC1 12) chain A residue 334 type sequence S description binding site for residue H4B A 802 source : AC2 13) chain A residue 596 type sequence R description binding site for residue H4B A 802 source : AC2 14) chain A residue 677 type sequence V description binding site for residue H4B A 802 source : AC2 15) chain A residue 678 type sequence W description binding site for residue H4B A 802 source : AC2 16) chain A residue 478 type sequence Q description binding site for residue BY7 A 803 source : AC3 17) chain A residue 567 type sequence V description binding site for residue BY7 A 803 source : AC3 18) chain A residue 584 type sequence F description binding site for residue BY7 A 803 source : AC3 19) chain A residue 586 type sequence G description binding site for residue BY7 A 803 source : AC3 20) chain A residue 587 type sequence W description binding site for residue BY7 A 803 source : AC3 21) chain A residue 588 type sequence Y description binding site for residue BY7 A 803 source : AC3 22) chain A residue 592 type sequence E description binding site for residue BY7 A 803 source : AC3 23) chain A residue 596 type sequence R description binding site for residue BY7 A 803 source : AC3 24) chain A residue 597 type sequence D description binding site for residue BY7 A 803 source : AC3 25) chain A residue 706 type sequence Y description binding site for residue BY7 A 803 source : AC3 26) chain A residue 587 type sequence W description binding site for residue ACT A 804 source : AC4 27) chain A residue 649 type sequence V description binding site for residue ACT A 804 source : AC4 28) chain A residue 478 type sequence Q description binding site for residue CL A 805 source : AC5 29) chain A residue 588 type sequence Y description binding site for residue CL A 805 source : AC5 30) chain A residue 597 type sequence D description binding site for residue CL A 805 source : AC5 31) chain A residue 326 type sequence C description binding site for residue ZN A 806 source : AC6 32) chain A residue 331 type sequence C description binding site for residue ZN A 806 source : AC6 33) chain A residue 676 type sequence W description binding site for residue H4B B 802 source : AC8 34) chain A residue 691 type sequence F description binding site for residue H4B B 802 source : AC8 35) chain A residue 692 type sequence H description binding site for residue H4B B 802 source : AC8 36) chain A residue 693 type sequence Q description binding site for residue H4B B 802 source : AC8 37) chain A residue 694 type sequence E description binding site for residue H4B B 802 source : AC8 38) chain A residue 334 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 39) chain A residue 478 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 40) chain A residue 587 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 41) chain A residue 588 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 42) chain A residue 592 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 43) chain A residue 677 type BINDING sequence V description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 44) chain A residue 678 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 45) chain A residue 691 type BINDING sequence F description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 46) chain A residue 706 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 47) chain A residue 415 type BINDING sequence C description axial binding residue => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI2 48) chain A residue 414-421 type prosite sequence RCVGRIQW description NOS Nitric oxide synthase (NOS) signature. RCVGRIqW source prosite : PS60001

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