eF-site ID 6auu-AB PDB Code 6auu Chain A, B click to enlarge Title Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(3-(3-(dimethylamino)propyl)-5-(trifluoromethyl)phenethyl)-4-methylpyridin-2-amine Classification OXIDOREDUCTASE Compound Nitric oxide synthase, brain Source (NOS1_RAT) Sequence A:  RFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLP DVRTKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNK EIESTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQV FDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRT DGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICI QQGWKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPI RHPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSG WYMGTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTSSLWK DQALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEY RCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEY QPDPWNTHVW B:  RFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLP VRTKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKE IESTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVF DARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTD GKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQ QGWKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIR HPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGW YMGTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTSSLWKD QALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYR CRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQ PDPWNTHVWKG Description Functional site 1) chain A residue 409 type sequence W description binding site for residue HEM A 801 source : AC1 2) chain A residue 415 type sequence C description binding site for residue HEM A 801 source : AC1 3) chain A residue 457 type sequence S description binding site for residue HEM A 801 source : AC1 4) chain A residue 584 type sequence F description binding site for residue HEM A 801 source : AC1 5) chain A residue 585 type sequence S description binding site for residue HEM A 801 source : AC1 6) chain A residue 587 type sequence W description binding site for residue HEM A 801 source : AC1 7) chain A residue 589 type sequence M description binding site for residue HEM A 801 source : AC1 8) chain A residue 592 type sequence E description binding site for residue HEM A 801 source : AC1 9) chain A residue 678 type sequence W description binding site for residue HEM A 801 source : AC1 10) chain A residue 704 type sequence F description binding site for residue HEM A 801 source : AC1 11) chain A residue 706 type sequence Y description binding site for residue HEM A 801 source : AC1 12) chain A residue 334 type sequence S description binding site for residue H4B A 802 source : AC2 13) chain A residue 596 type sequence R description binding site for residue H4B A 802 source : AC2 14) chain A residue 677 type sequence V description binding site for residue H4B A 802 source : AC2 15) chain A residue 678 type sequence W description binding site for residue H4B A 802 source : AC2 16) chain B residue 676 type sequence W description binding site for residue H4B A 802 source : AC2 17) chain B residue 691 type sequence F description binding site for residue H4B A 802 source : AC2 18) chain B residue 692 type sequence H description binding site for residue H4B A 802 source : AC2 19) chain B residue 693 type sequence Q description binding site for residue H4B A 802 source : AC2 20) chain B residue 694 type sequence E description binding site for residue H4B A 802 source : AC2 21) chain A residue 478 type sequence Q description binding site for residue BY7 A 803 source : AC3 22) chain A residue 567 type sequence V description binding site for residue BY7 A 803 source : AC3 23) chain A residue 584 type sequence F description binding site for residue BY7 A 803 source : AC3 24) chain A residue 586 type sequence G description binding site for residue BY7 A 803 source : AC3 25) chain A residue 587 type sequence W description binding site for residue BY7 A 803 source : AC3 26) chain A residue 588 type sequence Y description binding site for residue BY7 A 803 source : AC3 27) chain A residue 592 type sequence E description binding site for residue BY7 A 803 source : AC3 28) chain A residue 596 type sequence R description binding site for residue BY7 A 803 source : AC3 29) chain A residue 597 type sequence D description binding site for residue BY7 A 803 source : AC3 30) chain A residue 706 type sequence Y description binding site for residue BY7 A 803 source : AC3 31) chain A residue 587 type sequence W description binding site for residue ACT A 804 source : AC4 32) chain A residue 649 type sequence V description binding site for residue ACT A 804 source : AC4 33) chain A residue 478 type sequence Q description binding site for residue CL A 805 source : AC5 34) chain A residue 588 type sequence Y description binding site for residue CL A 805 source : AC5 35) chain A residue 597 type sequence D description binding site for residue CL A 805 source : AC5 36) chain A residue 326 type sequence C description binding site for residue ZN A 806 source : AC6 37) chain A residue 331 type sequence C description binding site for residue ZN A 806 source : AC6 38) chain B residue 326 type sequence C description binding site for residue ZN A 806 source : AC6 39) chain B residue 331 type sequence C description binding site for residue ZN A 806 source : AC6 40) chain B residue 409 type sequence W description binding site for residue HEM B 801 source : AC7 41) chain B residue 415 type sequence C description binding site for residue HEM B 801 source : AC7 42) chain B residue 457 type sequence S description binding site for residue HEM B 801 source : AC7 43) chain B residue 584 type sequence F description binding site for residue HEM B 801 source : AC7 44) chain B residue 585 type sequence S description binding site for residue HEM B 801 source : AC7 45) chain B residue 586 type sequence G description binding site for residue HEM B 801 source : AC7 46) chain B residue 587 type sequence W description binding site for residue HEM B 801 source : AC7 47) chain B residue 589 type sequence M description binding site for residue HEM B 801 source : AC7 48) chain B residue 592 type sequence E description binding site for residue HEM B 801 source : AC7 49) chain B residue 678 type sequence W description binding site for residue HEM B 801 source : AC7 50) chain B residue 704 type sequence F description binding site for residue HEM B 801 source : AC7 51) chain B residue 706 type sequence Y description binding site for residue HEM B 801 source : AC7 52) chain A residue 676 type sequence W description binding site for residue H4B B 802 source : AC8 53) chain A residue 691 type sequence F description binding site for residue H4B B 802 source : AC8 54) chain A residue 692 type sequence H description binding site for residue H4B B 802 source : AC8 55) chain A residue 693 type sequence Q description binding site for residue H4B B 802 source : AC8 56) chain A residue 694 type sequence E description binding site for residue H4B B 802 source : AC8 57) chain B residue 334 type sequence S description binding site for residue H4B B 802 source : AC8 58) chain B residue 336 type sequence M description binding site for residue H4B B 802 source : AC8 59) chain B residue 596 type sequence R description binding site for residue H4B B 802 source : AC8 60) chain B residue 677 type sequence V description binding site for residue H4B B 802 source : AC8 61) chain B residue 678 type sequence W description binding site for residue H4B B 802 source : AC8 62) chain B residue 478 type sequence Q description binding site for residue BY7 B 803 source : AC9 63) chain B residue 567 type sequence V description binding site for residue BY7 B 803 source : AC9 64) chain B residue 584 type sequence F description binding site for residue BY7 B 803 source : AC9 65) chain B residue 586 type sequence G description binding site for residue BY7 B 803 source : AC9 66) chain B residue 587 type sequence W description binding site for residue BY7 B 803 source : AC9 67) chain B residue 592 type sequence E description binding site for residue BY7 B 803 source : AC9 68) chain B residue 596 type sequence R description binding site for residue BY7 B 803 source : AC9 69) chain B residue 597 type sequence D description binding site for residue BY7 B 803 source : AC9 70) chain B residue 706 type sequence Y description binding site for residue BY7 B 803 source : AC9 71) chain B residue 587 type sequence W description binding site for residue ACT B 804 source : AD1 72) chain B residue 649 type sequence V description binding site for residue ACT B 804 source : AD1 73) chain B residue 477 type sequence S description binding site for residue MTL B 805 source : AD2 74) chain B residue 481 type sequence R description binding site for residue MTL B 805 source : AD2 75) chain B residue 497 type sequence A description binding site for residue MTL B 805 source : AD2 76) chain B residue 498 type sequence N description binding site for residue MTL B 805 source : AD2 77) chain B residue 500 type sequence Q description binding site for residue MTL B 805 source : AD2 78) chain B residue 501 type sequence F description binding site for residue MTL B 805 source : AD2 79) chain B residue 569 type sequence N description binding site for residue MTL B 805 source : AD2 80) chain B residue 709 type sequence D description binding site for residue MTL B 805 source : AD2 81) chain B residue 711 type sequence W description binding site for residue MTL B 805 source : AD2 82) chain B residue 588 type sequence Y description binding site for residue CL B 806 source : AD3 83) chain B residue 597 type sequence D description binding site for residue CL B 806 source : AD3 84) chain A residue 334 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 85) chain B residue 334 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 86) chain B residue 478 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 87) chain B residue 587 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 88) chain B residue 588 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 89) chain B residue 592 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 90) chain B residue 677 type BINDING sequence V description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 91) chain B residue 678 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 92) chain B residue 691 type BINDING sequence F description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 93) chain B residue 706 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 94) chain A residue 478 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 95) chain A residue 587 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 96) chain A residue 588 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 97) chain A residue 592 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 98) chain A residue 677 type BINDING sequence V description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 99) chain A residue 678 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 100) chain A residue 691 type BINDING sequence F description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 101) chain A residue 706 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 102) chain A residue 415 type BINDING sequence C description axial binding residue => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI2 103) chain B residue 415 type BINDING sequence C description axial binding residue => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI2 104) chain A residue 414-421 type prosite sequence RCVGRIQW description NOS Nitric oxide synthase (NOS) signature. RCVGRIqW source prosite : PS60001

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