eF-site ID 6ak9-ADPT PDB Code 6ak9 Chain A, D, P, T click to enlarge Title Pre-catalytic Ternary Complex of Human DNA Polymerase Mu with Templating Cytosine and Incoming Ca-8oxodGTP Classification TRANSFERASE/DNA Compound DNA-directed DNA/RNA polymerase mu Source (6AK9) Sequence A:  MPAYACQRPTPLTHHNTGLSEALEILAEAAGFEGSEGRLL TFCRAASVLKALPSPVTTLSQLQGLPHFGEHSSRVVQELL EHGVCEEVERVRRSERYQTMKLFTQIFGVGVKTADRWYRE GLRTLDDLREQPQKLTQQQKAGLQHHQDLSTPVLRSDVDA LQQVVEEAVGQALPGATVTLTGGFRRGKLQGHDVDFLITH PKEGQEAGLLPRVMCRLQDQGLILYHQHAFERSFCIFRLP QPGSWKAVRVDLVVAPVSQFPFALLGWTGSKLFQRELRRF SRKEKGLWLNSHGLFDPEQKTFFQAASEEDIFRHLGLEYL PPEQRNA D:  GCCG P:  CGTA T:  CGGCCTACG Description Functional site 1) chain A residue 330 type sequence D description binding site for residue CA A 501 source : AC1 2) chain A residue 332 type sequence D description binding site for residue CA A 501 source : AC1 3) chain A residue 330 type sequence D description binding site for residue CA A 502 source : AC2 4) chain A residue 332 type sequence D description binding site for residue CA A 502 source : AC2 5) chain A residue 418 type sequence D description binding site for residue CA A 502 source : AC2 6) chain P residue 4 type sequence A description binding site for residue CA A 502 source : AC2 7) chain A residue 319 type sequence G description binding site for residue 8DG A 503 source : AC3 8) chain A residue 320 type sequence G description binding site for residue 8DG A 503 source : AC3 9) chain A residue 323 type sequence R description binding site for residue 8DG A 503 source : AC3 10) chain A residue 325 type sequence K description binding site for residue 8DG A 503 source : AC3 11) chain A residue 328 type sequence G description binding site for residue 8DG A 503 source : AC3 12) chain A residue 329 type sequence H description binding site for residue 8DG A 503 source : AC3 13) chain A residue 330 type sequence D description binding site for residue 8DG A 503 source : AC3 14) chain A residue 332 type sequence D description binding site for residue 8DG A 503 source : AC3 15) chain A residue 433 type sequence G description binding site for residue 8DG A 503 source : AC3 16) chain A residue 434 type sequence W description binding site for residue 8DG A 503 source : AC3 17) chain A residue 436 type sequence G description binding site for residue 8DG A 503 source : AC3 18) chain A residue 438 type sequence K description binding site for residue 8DG A 503 source : AC3 19) chain A residue 445 type sequence R description binding site for residue 8DG A 503 source : AC3 20) chain P residue 4 type sequence A description binding site for residue 8DG A 503 source : AC3 21) chain T residue 5 type sequence C description binding site for residue 8DG A 503 source : AC3 22) chain A residue 241 type sequence T description binding site for residue NA A 504 source : AC4 23) chain A residue 243 type sequence I description binding site for residue NA A 504 source : AC4 24) chain A residue 246 type sequence V description binding site for residue NA A 504 source : AC4 25) chain P residue 3 type sequence T description binding site for residue NA A 504 source : AC4 26) chain A residue 325 type sequence K description binding site for residue EPE A 505 source : AC5 27) chain A residue 326 type sequence L description binding site for residue EPE A 505 source : AC5 28) chain A residue 327 type sequence Q description binding site for residue EPE A 505 source : AC5 29) chain A residue 387 type sequence R description binding site for residue EDO A 506 source : AC6 30) chain A residue 433 type sequence G description binding site for residue EDO A 506 source : AC6 31) chain A residue 434 type sequence W description binding site for residue EDO A 506 source : AC6 32) chain A residue 445 type sequence R description binding site for residue EDO A 506 source : AC6 33) chain A residue 458 type sequence S description binding site for residue EDO A 506 source : AC6 34) chain P residue 4 type sequence A description binding site for residue EDO A 506 source : AC6 35) chain A residue 190 type sequence P description binding site for residue EDO A 507 source : AC7 36) chain A residue 191 type sequence S description binding site for residue EDO A 507 source : AC7 37) chain A residue 192 type sequence P description binding site for residue EDO A 507 source : AC7 38) chain A residue 198 type sequence Q description binding site for residue EDO A 507 source : AC7 39) chain A residue 180 type sequence C description binding site for residue EDO A 508 source : AC8 40) chain A residue 438 type sequence K description binding site for residue EDO A 508 source : AC8 41) chain A residue 442 type sequence R description binding site for residue EDO A 508 source : AC8 42) chain A residue 433 type SITE sequence G description Responsible for the low discrimination between dNTP and rNTP source Swiss-Prot : SWS_FT_FI2 43) chain A residue 330 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 44) chain A residue 332 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 45) chain A residue 418 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 46) chain A residue 319-338 type prosite sequence GGFRRGKLQGHDVDFLITHP description DNA_POLYMERASE_X DNA polymerase family X signature. GGFrRGklqGhDVDFLIthP source prosite : PS00522

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