Title
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Cryo-EM structure of human Ribonuclease P |
Classification
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HYDROLASE/RNA |
Compound
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H1 RNA |
Source
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ORGANISM_COMMON: Human; ORGANISM_SCIENTIFIC: Homo sapiens; |
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Sequence
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B: |
KYITASTFAQARAAEISAMLKAVTQKSSNSLVFQTLPRHM
RRRAMSHNVKRLPRRLQEIAQKEAEKAARRCHMNRTLEFN
RRQKKNIWLETHIWHAKRFHMVKKWGYCLGERPTVKSHRA
CYRAMTNRCLLQDLSYYCCLELKGKEEEILKALSGMCNID
TGLTFAAVHCLSGKRQGSLVLYRVNKYPREMLGPVTFIWK
SQRTPGDPSESRQLWIWLHPTLKQDILEEIKAACQCVGEN
AKPIKKIIGDGTRDPCLPYSWISPTTGIIISDLTMEMNRF
RLIGPLSHSILTEAIKAASVHTVGEDTEETPHRWWIETCK
KPDSVSLHCRQEAIFELLGGITSPAEIPAGTILGLTVGDP
RINLPQKKSKALPNPEKCQDNEKVRQLLLEGVPVECTHSF
IWNQDICKSVTENKISDQDLNRMRSELLVPGSQLILGPHE
SKIPILLIQQPGKVTGEDRLGWGSGWDVLLPKGWGMAFWI
PFIYRGVRVGGLKESAVHSQYKRSPNVPGDFPDCPAGMLF
AEEQAKNLLEKYKRRPPAKRPNYVKLGTLAPFCCPWEQLT
QDWESRVQAYSHLCVLRSRKLLKQLSAWCGPSSEDSRGGR
RAPGRGQQGLTREACLSILGHFPRALVWVSLSLLSKGSPE
PHTMICVPAKEDFLQLHEDWHYCGPQESKHSDPFRSKILK
QKEKKKREKREALTLGLWSGPLPRVTLHCSRTLLGFVTQG
DFSMAVGCGEALGFVSLTGLLDMLSSQPAAQRGLVLLRPP
ASLQYRFARIAIEV
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C: |
LVVKTSLNNPYIIRWSALESEDMHFILQTLEDRLKAIGLQ
KIEDKKKKNPAHVRKQLAIGVNEVTRALERRELLLVLVCK
SVKPAMITSHLIQLSLSRSVPACQVPRLSERIAPVIGLKC
VLALAFKKNTTDFVDEVRAIIPRVPSLSVPWLQDRIEDSG
ENLETEPLESQDRELLDTSFED
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D: |
LSARQRRELRLFDIKPEQQRYSLFLPLHELWKQYIRDLCS
GLKPDTQPQMIQAKLLKADLHGAIISVTKSKCPSYVGITG
ILLQETKHIFKIITKEDRLKVIPKLNCVFTVETDGFISYI
YGSKFQLRSSERSAKKFKAKGTIDL
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E: |
VRFKHRYLLCELVSDDPRCRLSLDDRVLSSLVRDTIARVH
GTFGAAACSIGFAVRYLNAYTGIVLLRCRKEFYQLVWSAL
PFITYLENKGHRYPCFFNTLHVGGTIRTCQKFLIQYNRRQ
LLILLQNCTDEGEREAIQKSVTRSCLL
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F: |
MENFRKVRGGPGSGPFADLAPGAVHMRVKEGSKIRNLMAF
ATASMAQPATRAIVFSGCGRATTKTVTCAEILKRRLAGLH
QVTRLRYRSVREVWQSASLSVLKNVPGLAILLSKDALDPR
QPGYQPPNP
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G: |
GAVEAELDPVEYTLRKRLPSRLPRRPNDIYVNMKTDFKAQ
LARCQKLLDGGARGQNACSEIYIHGLGLAINRAINIALQL
QAGSFGSLQVAANTSTVELVDELEPETDTREPLTRIRNNS
AIHIRVFRVTP
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H: |
PAATYERVVYKNPSEYHYMKVCLEFQDCGVGLNAAQFKQL
LISAVKDLFGEVDAALPLDILTYEEKTLSAILRICSSGLV
KLWSSLTLLGSYKGKKCAFRVIQVSPFLLALSGNSRELVL
D
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I: |
AVFADLDLRAGSDLKALRGLVETAAHLGYSVVAINHIVDF
KEKKQEIEKPVAVSELFTTLPIVQGKSRPIKILTRLTIIV
SDPSHCNVLRATSSRARLYDVVAVFPKTEKLFHIACTHLD
VDLVCITVTEKLPFYFKRPPINVAIDRGLAFELVYSPAIK
DSTMRRYTISSALNLMQICKGKNVIISSAAERPLEIRGPY
DVANLGLLFGLSESDAKAAVSTNCRAALLHGETRKT
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J: |
AVFADLDLRAGSDLKALRGLVETAAHLGYSVVAINHIVDF
KEKKQEIEKPVAVSELFTTLPIVQGKSRPIKILTRLTIIV
SDPSHCNVLRATSSRARLYDVVAVFPKTEKLFHIACTHLD
VDLVCITVTEKLPFYFKRPPINVAIDRGLAFELVYSPAIK
DSTMRRYTISSALNLMQICKGKNVIISSAAERPLEIRGPY
DVANLGLLFGLSESDAKAAVSTNCRAALLHGETRKTAFGI
ISTVKKP
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K: |
PVKDREAFQRLNFLYQAAHCVLAQDPENQALARFYCYTER
TIAKRLVLRRDPSVKRTLCRGCSSLLVPGLTCTQRQRRCR
GQRWTVQTCLTCQRSQRFLNDPGHLLWGDRPEAQLGSQAD
S
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L: |
ATLRRLREAPRHLLVCEKSNFGNHKSRHRHLVQTHYYNYR
VSFLIPECGILSEELKNLVMNTGPYYFVKNLPLHELITPE
FISTFIKKGSCYALTYNTHIDEDNTVALLPNGKLILSLDK
DTYEETGLQGHPSQFSGRKIMKFIVSIDLMELSLNLDSKK
YERISWSFKEKKPLKFDFLLAWHKTGSEESTMMSYFSKYQ
IQEHQPKVALSTLRDLQCPVLQSSELEGTPEVSCRALELF
DWLGAVFSNVDLNNEPNNFISTYCCPEPSTVVAKAYLCTI
TGFILPEKICLLLEHLCHYFDEPKLAPWVTLSVQGFADSP
VSWEKNEHGFRKGGEHLYNFVIFNNQDYWLQMAVGANDHC
PP
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Description
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