eF-site ID 6ahr-ABCDEFGHIJKL PDB Code 6ahr Chain A, B, C, D, E, F, G, H, I, J, K, L Title Cryo-EM structure of human Ribonuclease P Classification HYDROLASE/RNA Compound H1 RNA Source ORGANISM_COMMON: Human; ORGANISM_SCIENTIFIC: Homo sapiens; Sequence A:  AUAGGGCGGAGGGAAGCUCAUCAGUGGGGCCACGAGCUGA GUGCGUCCUGUCACUCCACUCCCAUGUCCCUUGGGAAGGU CUGAGACUAGGGCCAGAGGCGGCCCUAACAGGGCUCUCCC UGAGCUUCGGGGAGGUGAGUUCCCAGAGAACGGGGCUCCG CGCGAGGUCAGACUGGGCAGGAGAUGCCGUGGACCCCGCC CUUCGGGGAGGGGCCCGGCGGAUGCCUCCUUUGCCGGAGC UUGGAACAGACUCACGGCCAGCGAAGUGAGUUCAAUGGCU GAGGUGAGGUACCCCGCAGGGGACCUCAUAACCCAAUUCA GACUACUCUCCUCCGCCCAUU B:  KYITASTFAQARAAEISAMLKAVTQKSSNSLVFQTLPRHM RRRAMSHNVKRLPRRLQEIAQKEAEKAARRCHMNRTLEFN RRQKKNIWLETHIWHAKRFHMVKKWGYCLGERPTVKSHRA CYRAMTNRCLLQDLSYYCCLELKGKEEEILKALSGMCNID TGLTFAAVHCLSGKRQGSLVLYRVNKYPREMLGPVTFIWK SQRTPGDPSESRQLWIWLHPTLKQDILEEIKAACQCVGEN AKPIKKIIGDGTRDPCLPYSWISPTTGIIISDLTMEMNRF RLIGPLSHSILTEAIKAASVHTVGEDTEETPHRWWIETCK KPDSVSLHCRQEAIFELLGGITSPAEIPAGTILGLTVGDP RINLPQKKSKALPNPEKCQDNEKVRQLLLEGVPVECTHSF IWNQDICKSVTENKISDQDLNRMRSELLVPGSQLILGPHE SKIPILLIQQPGKVTGEDRLGWGSGWDVLLPKGWGMAFWI PFIYRGVRVGGLKESAVHSQYKRSPNVPGDFPDCPAGMLF AEEQAKNLLEKYKRRPPAKRPNYVKLGTLAPFCCPWEQLT QDWESRVQAYSHLCVLRSRKLLKQLSAWCGPSSEDSRGGR RAPGRGQQGLTREACLSILGHFPRALVWVSLSLLSKGSPE PHTMICVPAKEDFLQLHEDWHYCGPQESKHSDPFRSKILK QKEKKKREKREALTLGLWSGPLPRVTLHCSRTLLGFVTQG DFSMAVGCGEALGFVSLTGLLDMLSSQPAAQRGLVLLRPP ASLQYRFARIAIEV C:  LVVKTSLNNPYIIRWSALESEDMHFILQTLEDRLKAIGLQ KIEDKKKKNPAHVRKQLAIGVNEVTRALERRELLLVLVCK SVKPAMITSHLIQLSLSRSVPACQVPRLSERIAPVIGLKC VLALAFKKNTTDFVDEVRAIIPRVPSLSVPWLQDRIEDSG ENLETEPLESQDRELLDTSFED D:  LSARQRRELRLFDIKPEQQRYSLFLPLHELWKQYIRDLCS GLKPDTQPQMIQAKLLKADLHGAIISVTKSKCPSYVGITG ILLQETKHIFKIITKEDRLKVIPKLNCVFTVETDGFISYI YGSKFQLRSSERSAKKFKAKGTIDL E:  VRFKHRYLLCELVSDDPRCRLSLDDRVLSSLVRDTIARVH GTFGAAACSIGFAVRYLNAYTGIVLLRCRKEFYQLVWSAL PFITYLENKGHRYPCFFNTLHVGGTIRTCQKFLIQYNRRQ LLILLQNCTDEGEREAIQKSVTRSCLL F:  MENFRKVRGGPGSGPFADLAPGAVHMRVKEGSKIRNLMAF ATASMAQPATRAIVFSGCGRATTKTVTCAEILKRRLAGLH QVTRLRYRSVREVWQSASLSVLKNVPGLAILLSKDALDPR QPGYQPPNP G:  GAVEAELDPVEYTLRKRLPSRLPRRPNDIYVNMKTDFKAQ LARCQKLLDGGARGQNACSEIYIHGLGLAINRAINIALQL QAGSFGSLQVAANTSTVELVDELEPETDTREPLTRIRNNS AIHIRVFRVTP H:  PAATYERVVYKNPSEYHYMKVCLEFQDCGVGLNAAQFKQL LISAVKDLFGEVDAALPLDILTYEEKTLSAILRICSSGLV KLWSSLTLLGSYKGKKCAFRVIQVSPFLLALSGNSRELVL D I:  AVFADLDLRAGSDLKALRGLVETAAHLGYSVVAINHIVDF KEKKQEIEKPVAVSELFTTLPIVQGKSRPIKILTRLTIIV SDPSHCNVLRATSSRARLYDVVAVFPKTEKLFHIACTHLD VDLVCITVTEKLPFYFKRPPINVAIDRGLAFELVYSPAIK DSTMRRYTISSALNLMQICKGKNVIISSAAERPLEIRGPY DVANLGLLFGLSESDAKAAVSTNCRAALLHGETRKT J:  AVFADLDLRAGSDLKALRGLVETAAHLGYSVVAINHIVDF KEKKQEIEKPVAVSELFTTLPIVQGKSRPIKILTRLTIIV SDPSHCNVLRATSSRARLYDVVAVFPKTEKLFHIACTHLD VDLVCITVTEKLPFYFKRPPINVAIDRGLAFELVYSPAIK DSTMRRYTISSALNLMQICKGKNVIISSAAERPLEIRGPY DVANLGLLFGLSESDAKAAVSTNCRAALLHGETRKTAFGI ISTVKKP K:  PVKDREAFQRLNFLYQAAHCVLAQDPENQALARFYCYTER TIAKRLVLRRDPSVKRTLCRGCSSLLVPGLTCTQRQRRCR GQRWTVQTCLTCQRSQRFLNDPGHLLWGDRPEAQLGSQAD S L:  ATLRRLREAPRHLLVCEKSNFGNHKSRHRHLVQTHYYNYR VSFLIPECGILSEELKNLVMNTGPYYFVKNLPLHELITPE FISTFIKKGSCYALTYNTHIDEDNTVALLPNGKLILSLDK DTYEETGLQGHPSQFSGRKIMKFIVSIDLMELSLNLDSKK YERISWSFKEKKPLKFDFLLAWHKTGSEESTMMSYFSKYQ IQEHQPKVALSTLRDLQCPVLQSSELEGTPEVSCRALELF DWLGAVFSNVDLNNEPNNFISTYCCPEPSTVVAKAYLCTI TGFILPEKICLLLEHLCHYFDEPKLAPWVTLSVQGFADSP VSWEKNEHGFRKGGEHLYNFVIFNNQDYWLQMAVGANDHC PP Description Functional site 1) chain K residue 62 type sequence C description binding site for residue ZN K 201 source : AC1 2) chain K residue 64 type sequence G description binding site for residue ZN K 201 source : AC1 3) chain K residue 65 type sequence C description binding site for residue ZN K 201 source : AC1 4) chain K residue 92 type sequence C description binding site for residue ZN K 201 source : AC1 5) chain K residue 95 type sequence C description binding site for residue ZN K 201 source : AC1 6) chain K residue 62 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 7) chain K residue 65 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 8) chain K residue 92 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 9) chain K residue 95 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 10) chain C residue 226 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:21406692 source Swiss-Prot : SWS_FT_FI3 11) chain C residue 235 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4

Display surface Download Links