eF-site ID 6ah4-ABC
PDB Code 6ah4
Chain A, B, C

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Title Structure of human P2X3 receptor in complex with ATP and Ca2+ ion
Classification MEMBRANE PROTEIN
Compound P2X purinoceptor 3
Source (P2RX3_HUMAN)
Sequence A:  FFTYETPKVIVVKSWTIGIINRVVQLLIISYFVGWVFLHE
KAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQG
TSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPER
LPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMM
EAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFH
PDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWV
CDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYY
KMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSV
AAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNE
B:  FFTYETPKVIVVKSWTIGIINRVVQLLIISYFVGWVFLHE
KAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQG
TSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPER
LPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMM
EAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFH
PDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWV
CDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYY
KMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSV
AAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNE
C:  FFTYETPKVIVVKSWTIGIINRVVQLLIISYFVGWVFLHE
KAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQG
TSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPER
LPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMM
EAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFH
PDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWV
CDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYY
KMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSV
AAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNE
Description (1)  P2X purinoceptor 3


Functional site
1) chain A
residue 194
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:27626375, ECO:0007744|PDB:5SVJ, ECO:0007744|PDB:5SVK, ECO:0007744|PDB:5SVL, ECO:0007744|PDB:5SVM, ECO:0007744|PDB:5SVP, ECO:0007744|PDB:5SVQ, ECO:0007744|PDB:5SVS, ECO:0007744|PDB:5SVT
source Swiss-Prot : SWS_FT_FI7
2) chain B
residue 194
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:27626375, ECO:0007744|PDB:5SVJ, ECO:0007744|PDB:5SVK, ECO:0007744|PDB:5SVL, ECO:0007744|PDB:5SVM, ECO:0007744|PDB:5SVP, ECO:0007744|PDB:5SVQ, ECO:0007744|PDB:5SVS, ECO:0007744|PDB:5SVT
source Swiss-Prot : SWS_FT_FI7
3) chain C
residue 194
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:27626375, ECO:0007744|PDB:5SVJ, ECO:0007744|PDB:5SVK, ECO:0007744|PDB:5SVL, ECO:0007744|PDB:5SVM, ECO:0007744|PDB:5SVP, ECO:0007744|PDB:5SVQ, ECO:0007744|PDB:5SVS, ECO:0007744|PDB:5SVT
source Swiss-Prot : SWS_FT_FI7
4) chain A
residue 21-43
type TRANSMEM
sequence WTIGIINRVVQLLIISYFVGWVF
description Helical; Name=1 => ECO:0000269|PubMed:27626375
source Swiss-Prot : SWS_FT_FI1
5) chain B
residue 21-43
type TRANSMEM
sequence WTIGIINRVVQLLIISYFVGWVF
description Helical; Name=1 => ECO:0000269|PubMed:27626375
source Swiss-Prot : SWS_FT_FI1
6) chain C
residue 21-43
type TRANSMEM
sequence WTIGIINRVVQLLIISYFVGWVF
description Helical; Name=1 => ECO:0000269|PubMed:27626375
source Swiss-Prot : SWS_FT_FI1
7) chain A
residue 44-322
type TOPO_DOM
sequence LHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTP
PQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCG
PERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETP
IMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTC
RFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKI
GWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFA
KYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTI
description Extracellular => ECO:0000269|PubMed:27626375
source Swiss-Prot : SWS_FT_FI2
8) chain B
residue 44-322
type TOPO_DOM
sequence LHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTP
PQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCG
PERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETP
IMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTC
RFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKI
GWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFA
KYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTI
description Extracellular => ECO:0000269|PubMed:27626375
source Swiss-Prot : SWS_FT_FI2
9) chain C
residue 44-322
type TOPO_DOM
sequence LHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTP
PQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCG
PERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETP
IMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTC
RFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKI
GWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFA
KYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTI
description Extracellular => ECO:0000269|PubMed:27626375
source Swiss-Prot : SWS_FT_FI2
10) chain A
residue 323-341
type TRANSMEM
sequence ISSVAAFTSVGVGTVLCDI
description Helical; Name=2 => ECO:0000269|PubMed:27626375
source Swiss-Prot : SWS_FT_FI3
11) chain B
residue 323-341
type TRANSMEM
sequence ISSVAAFTSVGVGTVLCDI
description Helical; Name=2 => ECO:0000269|PubMed:27626375
source Swiss-Prot : SWS_FT_FI3
12) chain C
residue 323-341
type TRANSMEM
sequence ISSVAAFTSVGVGTVLCDI
description Helical; Name=2 => ECO:0000269|PubMed:27626375
source Swiss-Prot : SWS_FT_FI3
13) chain A
residue 63
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:27626375, ECO:0007744|PDB:5SVK, ECO:0007744|PDB:5SVL, ECO:0007744|PDB:5SVM, ECO:0007744|PDB:5SVP
source Swiss-Prot : SWS_FT_FI4
14) chain B
residue 299
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:27626375, ECO:0007744|PDB:5SVK, ECO:0007744|PDB:5SVL, ECO:0007744|PDB:5SVM, ECO:0007744|PDB:5SVP
source Swiss-Prot : SWS_FT_FI4
15) chain C
residue 63
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:27626375, ECO:0007744|PDB:5SVK, ECO:0007744|PDB:5SVL, ECO:0007744|PDB:5SVM, ECO:0007744|PDB:5SVP
source Swiss-Prot : SWS_FT_FI4
16) chain C
residue 172
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:27626375, ECO:0007744|PDB:5SVK, ECO:0007744|PDB:5SVL, ECO:0007744|PDB:5SVM, ECO:0007744|PDB:5SVP
source Swiss-Prot : SWS_FT_FI4
17) chain C
residue 275
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:27626375, ECO:0007744|PDB:5SVK, ECO:0007744|PDB:5SVL, ECO:0007744|PDB:5SVM, ECO:0007744|PDB:5SVP
source Swiss-Prot : SWS_FT_FI4
18) chain C
residue 279
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:27626375, ECO:0007744|PDB:5SVK, ECO:0007744|PDB:5SVL, ECO:0007744|PDB:5SVM, ECO:0007744|PDB:5SVP
source Swiss-Prot : SWS_FT_FI4
19) chain C
residue 299
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:27626375, ECO:0007744|PDB:5SVK, ECO:0007744|PDB:5SVL, ECO:0007744|PDB:5SVM, ECO:0007744|PDB:5SVP
source Swiss-Prot : SWS_FT_FI4
20) chain A
residue 172
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:27626375, ECO:0007744|PDB:5SVK, ECO:0007744|PDB:5SVL, ECO:0007744|PDB:5SVM, ECO:0007744|PDB:5SVP
source Swiss-Prot : SWS_FT_FI4
21) chain A
residue 275
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:27626375, ECO:0007744|PDB:5SVK, ECO:0007744|PDB:5SVL, ECO:0007744|PDB:5SVM, ECO:0007744|PDB:5SVP
source Swiss-Prot : SWS_FT_FI4
22) chain A
residue 279
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:27626375, ECO:0007744|PDB:5SVK, ECO:0007744|PDB:5SVL, ECO:0007744|PDB:5SVM, ECO:0007744|PDB:5SVP
source Swiss-Prot : SWS_FT_FI4
23) chain A
residue 299
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:27626375, ECO:0007744|PDB:5SVK, ECO:0007744|PDB:5SVL, ECO:0007744|PDB:5SVM, ECO:0007744|PDB:5SVP
source Swiss-Prot : SWS_FT_FI4
24) chain B
residue 63
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:27626375, ECO:0007744|PDB:5SVK, ECO:0007744|PDB:5SVL, ECO:0007744|PDB:5SVM, ECO:0007744|PDB:5SVP
source Swiss-Prot : SWS_FT_FI4
25) chain B
residue 172
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:27626375, ECO:0007744|PDB:5SVK, ECO:0007744|PDB:5SVL, ECO:0007744|PDB:5SVM, ECO:0007744|PDB:5SVP
source Swiss-Prot : SWS_FT_FI4
26) chain B
residue 275
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:27626375, ECO:0007744|PDB:5SVK, ECO:0007744|PDB:5SVL, ECO:0007744|PDB:5SVM, ECO:0007744|PDB:5SVP
source Swiss-Prot : SWS_FT_FI4
27) chain B
residue 279
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:27626375, ECO:0007744|PDB:5SVK, ECO:0007744|PDB:5SVL, ECO:0007744|PDB:5SVM, ECO:0007744|PDB:5SVP
source Swiss-Prot : SWS_FT_FI4
28) chain A
residue 139
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:27626375, ECO:0007744|PDB:5SVK
source Swiss-Prot : SWS_FT_FI5
29) chain B
residue 139
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:27626375, ECO:0007744|PDB:5SVK
source Swiss-Prot : SWS_FT_FI5
30) chain C
residue 139
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:27626375, ECO:0007744|PDB:5SVK
source Swiss-Prot : SWS_FT_FI5
31) chain A
residue 236-262
type prosite
sequence GGVLGIKIGWVCDLDKAWDQCIPKYSF
description P2X_RECEPTOR ATP P2X receptors signature. GGvLGIkIgWvCDLDkawdqCiPkYsF
source prosite : PS01212
32) chain A
residue 170
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:27626375, ECO:0007744|PDB:5SVJ, ECO:0007744|PDB:5SVK, ECO:0007744|PDB:5SVL, ECO:0007744|PDB:5SVM, ECO:0007744|PDB:5SVP, ECO:0007744|PDB:5SVQ, ECO:0007744|PDB:5SVR, ECO:0007744|PDB:5SVS, ECO:0007744|PDB:5SVT
source Swiss-Prot : SWS_FT_FI6
33) chain A
residue 290
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:27626375, ECO:0007744|PDB:5SVJ, ECO:0007744|PDB:5SVK, ECO:0007744|PDB:5SVL, ECO:0007744|PDB:5SVM, ECO:0007744|PDB:5SVP, ECO:0007744|PDB:5SVQ, ECO:0007744|PDB:5SVR, ECO:0007744|PDB:5SVS, ECO:0007744|PDB:5SVT
source Swiss-Prot : SWS_FT_FI6
34) chain B
residue 170
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:27626375, ECO:0007744|PDB:5SVJ, ECO:0007744|PDB:5SVK, ECO:0007744|PDB:5SVL, ECO:0007744|PDB:5SVM, ECO:0007744|PDB:5SVP, ECO:0007744|PDB:5SVQ, ECO:0007744|PDB:5SVR, ECO:0007744|PDB:5SVS, ECO:0007744|PDB:5SVT
source Swiss-Prot : SWS_FT_FI6
35) chain B
residue 290
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:27626375, ECO:0007744|PDB:5SVJ, ECO:0007744|PDB:5SVK, ECO:0007744|PDB:5SVL, ECO:0007744|PDB:5SVM, ECO:0007744|PDB:5SVP, ECO:0007744|PDB:5SVQ, ECO:0007744|PDB:5SVR, ECO:0007744|PDB:5SVS, ECO:0007744|PDB:5SVT
source Swiss-Prot : SWS_FT_FI6
36) chain C
residue 170
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:27626375, ECO:0007744|PDB:5SVJ, ECO:0007744|PDB:5SVK, ECO:0007744|PDB:5SVL, ECO:0007744|PDB:5SVM, ECO:0007744|PDB:5SVP, ECO:0007744|PDB:5SVQ, ECO:0007744|PDB:5SVR, ECO:0007744|PDB:5SVS, ECO:0007744|PDB:5SVT
source Swiss-Prot : SWS_FT_FI6
37) chain C
residue 290
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:27626375, ECO:0007744|PDB:5SVJ, ECO:0007744|PDB:5SVK, ECO:0007744|PDB:5SVL, ECO:0007744|PDB:5SVM, ECO:0007744|PDB:5SVP, ECO:0007744|PDB:5SVQ, ECO:0007744|PDB:5SVR, ECO:0007744|PDB:5SVS, ECO:0007744|PDB:5SVT
source Swiss-Prot : SWS_FT_FI6

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