eF-site ID 6aej-A PDB Code 6aej Chain A click to enlarge Title Crystal structure of human FTO in complex with small-molecule inhibitors Classification OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR Compound Alpha-ketoglutarate-dependent dioxygenase FTO,Alpha-ketoglutarate-dependent dioxygenase FTO Source (FTO_HUMAN) Sequence A:  RGSHMTPKDDEFYQQWQLKYPKLILREASSVSEELHKEVQ EAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTY KYLNTRLFTVPWPVKEAEIAAACETFLKLNDYLQIETIQA LEELAADIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGK MAVSWHHDENLVDRSAVAVYSYSCEGRDPDIWHVGFKISW DIETPGLAIPLHQGDCYFMLDDLNATHQHCVLAGSQPRFS STHRVAECSTGTLDYILQRCQLALQNVCDDVDNDDVSLKS FEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQ PMAQLEALWKKMEGVTNAVLHEVKREGLPVEQRNEILTAI LASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEK DDASMPLPFDLTDIVSELRGQ Description Functional site 1) chain A residue 96 type sequence R description binding site for residue 7YC A 601 source : AC1 2) chain A residue 106 type sequence Y description binding site for residue 7YC A 601 source : AC1 3) chain A residue 108 type sequence Y description binding site for residue 7YC A 601 source : AC1 4) chain A residue 205 type sequence N description binding site for residue 7YC A 601 source : AC1 5) chain A residue 228 type sequence V description binding site for residue 7YC A 601 source : AC1 6) chain A residue 231 type sequence H description binding site for residue 7YC A 601 source : AC1 7) chain A residue 232 type sequence H description binding site for residue 7YC A 601 source : AC1 8) chain A residue 233 type sequence D description binding site for residue 7YC A 601 source : AC1 9) chain A residue 234 type sequence E description binding site for residue 7YC A 601 source : AC1 10) chain A residue 295 type sequence Y description binding site for residue 7YC A 601 source : AC1 11) chain A residue 307 type sequence H description binding site for residue 7YC A 601 source : AC1 12) chain A residue 309 type sequence V description binding site for residue 7YC A 601 source : AC1 13) chain A residue 316 type sequence R description binding site for residue 7YC A 601 source : AC1 14) chain A residue 318 type sequence S description binding site for residue 7YC A 601 source : AC1 15) chain A residue 320 type sequence T description binding site for residue 7YC A 601 source : AC1 16) chain A residue 322 type sequence R description binding site for residue 7YC A 601 source : AC1 17) chain A residue 231 type sequence H description binding site for residue ZN A 602 source : AC2 18) chain A residue 233 type sequence D description binding site for residue ZN A 602 source : AC2 19) chain A residue 307 type sequence H description binding site for residue ZN A 602 source : AC2 20) chain A residue 233 type BINDING sequence D description BINDING => ECO:0000269|PubMed:20376003, ECO:0000305|PubMed:23547775, ECO:0000305|PubMed:25452335, ECO:0000305|PubMed:26457839, ECO:0000305|PubMed:28553460, ECO:0007744|PDB:3LFM, ECO:0007744|PDB:4CXW, ECO:0007744|PDB:4CXX, ECO:0007744|PDB:4CXY, ECO:0007744|PDB:4IDZ, ECO:0007744|PDB:4IE0, ECO:0007744|PDB:4IE4, ECO:0007744|PDB:4IE5, ECO:0007744|PDB:4IE6, ECO:0007744|PDB:4IE7, ECO:0007744|PDB:4QKN, ECO:0007744|PDB:4ZS2, ECO:0007744|PDB:4ZS3 source Swiss-Prot : SWS_FT_FI4 21) chain A residue 307 type BINDING sequence H description BINDING => ECO:0000269|PubMed:20376003, ECO:0000305|PubMed:23547775, ECO:0000305|PubMed:25452335, ECO:0000305|PubMed:26457839, ECO:0000305|PubMed:28553460, ECO:0007744|PDB:3LFM, ECO:0007744|PDB:4CXW, ECO:0007744|PDB:4CXX, ECO:0007744|PDB:4CXY, ECO:0007744|PDB:4IDZ, ECO:0007744|PDB:4IE0, ECO:0007744|PDB:4IE4, ECO:0007744|PDB:4IE5, ECO:0007744|PDB:4IE6, ECO:0007744|PDB:4IE7, ECO:0007744|PDB:4QKN, ECO:0007744|PDB:4ZS2, ECO:0007744|PDB:4ZS3 source Swiss-Prot : SWS_FT_FI4 22) chain A residue 216 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI7 23) chain A residue 231 type BINDING sequence H description BINDING => ECO:0000269|PubMed:20376003, ECO:0000269|PubMed:25452335, ECO:0000305|PubMed:23547775, ECO:0000305|PubMed:25452335, ECO:0000305|PubMed:26457839, ECO:0000305|PubMed:28553460, ECO:0007744|PDB:3LFM, ECO:0007744|PDB:4CXW, ECO:0007744|PDB:4CXX, ECO:0007744|PDB:4CXY, ECO:0007744|PDB:4IDZ, ECO:0007744|PDB:4IE0, ECO:0007744|PDB:4IE4, ECO:0007744|PDB:4IE5, ECO:0007744|PDB:4IE6, ECO:0007744|PDB:4IE7, ECO:0007744|PDB:4QKN, ECO:0007744|PDB:4ZS2, ECO:0007744|PDB:4ZS3 source Swiss-Prot : SWS_FT_FI3 24) chain A residue 96 type BINDING sequence R description BINDING => ECO:0000269|PubMed:20376003, ECO:0007744|PDB:3LFM source Swiss-Prot : SWS_FT_FI1 25) chain A residue 108 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:20376003, ECO:0007744|PDB:3LFM source Swiss-Prot : SWS_FT_FI1 26) chain A residue 320 type BINDING sequence T description BINDING => ECO:0000269|PubMed:20376003, ECO:0007744|PDB:3LFM source Swiss-Prot : SWS_FT_FI1 27) chain A residue 205 type BINDING sequence N description BINDING => ECO:0000269|PubMed:20376003, ECO:0000269|PubMed:25452335, ECO:0007744|PDB:3LFM, ECO:0007744|PDB:4QKN source Swiss-Prot : SWS_FT_FI2 28) chain A residue 295 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:20376003, ECO:0000269|PubMed:25452335, ECO:0000269|PubMed:26457839, ECO:0007744|PDB:3LFM, ECO:0007744|PDB:4QKN, ECO:0007744|PDB:4ZS2, ECO:0007744|PDB:4ZS3 source Swiss-Prot : SWS_FT_FI5 29) chain A residue 316 type BINDING sequence R description BINDING => ECO:0000269|PubMed:20376003, ECO:0000269|PubMed:25452335, ECO:0000269|PubMed:26457839, ECO:0007744|PDB:3LFM, ECO:0007744|PDB:4QKN, ECO:0007744|PDB:4ZS2, ECO:0007744|PDB:4ZS3 source Swiss-Prot : SWS_FT_FI5 30) chain A residue 322 type BINDING sequence R description BINDING => ECO:0000269|PubMed:20376003, ECO:0000269|PubMed:25452335, ECO:0000269|PubMed:26457839, ECO:0007744|PDB:3LFM, ECO:0007744|PDB:4QKN, ECO:0007744|PDB:4ZS2 source Swiss-Prot : SWS_FT_FI6

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