eF-site ID 6a94-B
PDB Code 6a94
Chain B

click to enlarge
Title Crystal structure of 5-HT2AR in complex with zotepine
Classification MEMBRANE PROTEIN
Compound 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562
Source (5HT2A_HUMAN)
Sequence B:  QEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNY
FLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVW
IYLDVLFSTAKIWHLCAISLDRYVAIQNPSRTKAFLKIIA
VWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIG
SFVSFFIPLTIMVITYFLTIKSLQKEAADLEDNWETLNDN
LKVIEKADNAAQVKDALTKMRAAALDAGGDILVGQIDDAL
KLANEGKVKEAQAAAEQLKTTINAYIQKYGQSISNEQKAC
KVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALL
NVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKE
Description


Functional site

1) chain B
residue 155
type
sequence D
description binding site for residue ZOT B 3001
source : AC5

2) chain B
residue 156
type
sequence V
description binding site for residue ZOT B 3001
source : AC5

3) chain B
residue 159
type
sequence S
description binding site for residue ZOT B 3001
source : AC5

4) chain B
residue 160
type
sequence T
description binding site for residue ZOT B 3001
source : AC5

5) chain B
residue 229
type
sequence L
description binding site for residue ZOT B 3001
source : AC5

6) chain B
residue 235
type
sequence V
description binding site for residue ZOT B 3001
source : AC5

7) chain B
residue 238
type
sequence G
description binding site for residue ZOT B 3001
source : AC5

8) chain B
residue 242
type
sequence S
description binding site for residue ZOT B 3001
source : AC5

9) chain B
residue 339
type
sequence F
description binding site for residue ZOT B 3001
source : AC5

10) chain B
residue 340
type
sequence F
description binding site for residue ZOT B 3001
source : AC5

11) chain B
residue 395
type
sequence I
description binding site for residue PLM B 3002
source : AC6

12) chain B
residue 396
type
sequence Q
description binding site for residue PLM B 3002
source : AC6

13) chain B
residue 397
type
sequence C
description binding site for residue PLM B 3002
source : AC6

14) chain B
residue 86
type
sequence I
description binding site for residue CLR B 3003
source : AC7

15) chain B
residue 394
type
sequence Y
description binding site for residue CLR B 3003
source : AC7

16) chain B
residue 399
type
sequence Y
description binding site for residue CLR B 3003
source : AC7

17) chain B
residue 399
type
sequence Y
description binding site for residue A6L B 3004
source : AC8

18) chain B
residue 1007
type BINDING
sequence W
description axial binding residue
source Swiss-Prot : SWS_FT_FI12

19) chain B
residue 1102
type BINDING
sequence I
description axial binding residue
source Swiss-Prot : SWS_FT_FI12

20) chain B
residue 155
type BINDING
sequence D
description BINDING => ECO:0000250|UniProtKB:P41595
source Swiss-Prot : SWS_FT_FI10

21) chain B
residue 160
type BINDING
sequence T
description BINDING => ECO:0000250|UniProtKB:P41595
source Swiss-Prot : SWS_FT_FI10

22) chain B
residue 229
type BINDING
sequence L
description BINDING => ECO:0000250|UniProtKB:P41595
source Swiss-Prot : SWS_FT_FI10

23) chain B
residue 229
type SITE
sequence L
description Hydrophobic barrier that decreases the speed of ligand binding and dissociation => ECO:0000269|PubMed:28129538
source Swiss-Prot : SWS_FT_FI11

24) chain B
residue 76-99
type TRANSMEM
sequence WSALLTAVVIILTIAGNILVIMAV
description Helical; Name=1 => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

25) chain B
residue 363-384
type TRANSMEM
sequence NVFVWIGYLSSAVNPLVYTLFN
description Helical; Name=7 => ECO:0000250
source Swiss-Prot : SWS_FT_FI9

26) chain B
residue 100-110
type TOPO_DOM
sequence SLEKKLQNATN
description Cytoplasmic => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

27) chain B
residue 172-191
type TOPO_DOM
sequence DRYVAIQNPSRTK
description Cytoplasmic => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

28) chain B
residue 111-132
type TRANSMEM
sequence YFLMSLAIADMLLGFLVMPVSM
description Helical; Name=2 => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

29) chain B
residue 133-148
type TOPO_DOM
sequence LTILYGYRWPLPSKLC
description Extracellular => ECO:0000250
source Swiss-Prot : SWS_FT_FI4

30) chain B
residue 216-233
type TOPO_DOM
sequence QDDSKVFKEGSCLLADDN
description Extracellular => ECO:0000250
source Swiss-Prot : SWS_FT_FI4

31) chain B
residue 347-362
type TOPO_DOM
sequence VICKESCNEDVIGALL
description Extracellular => ECO:0000250
source Swiss-Prot : SWS_FT_FI4

32) chain B
residue 149-171
type TRANSMEM
sequence AVWIYLDVLFSTAKIWHLCAISL
description Helical; Name=3 => ECO:0000250
source Swiss-Prot : SWS_FT_FI5

33) chain B
residue 192-215
type TRANSMEM
sequence AFLKIIAVWTISVGISMPIPVFGL
description Helical; Name=4 => ECO:0000250
source Swiss-Prot : SWS_FT_FI6

34) chain B
residue 234-254
type TRANSMEM
sequence FVLIGSFVSFFIPLTIMVITY
description Helical; Name=5 => ECO:0000250
source Swiss-Prot : SWS_FT_FI7

35) chain B
residue 325-346
type TRANSMEM
sequence LGIVFFLFVVMWCPFFITNIMA
description Helical; Name=6 => ECO:0000250
source Swiss-Prot : SWS_FT_FI8


Display surface

Download
Links