eF-site ID 6a91-AB
PDB Code 6a91
Chain A, B

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Title Complex of voltage-gated sodium channel NavPaS from American cockroach Periplaneta americana bound with saxitoxin and Dc1a
Classification MEMBRANE PROTEIN/TOXIN
Compound Sodium channel protein PaFPC1
Source (TXI92_DIGCA)
Sequence A:  DKGRGANKDRDGSAHPDQALEQGSRLPARMRNIFPAELAS
TPLEDFDPFYKNKKTFVVVTKAGDIFRFSGEKSLWMLDPF
TPIRRVAISTMVQPIFSYFIMITILIHCIFMIMPATQTTY
ILELVFLSIYTIEVVVKVLARGFILHPFAYLRDPWNWLDF
LVTLIGYITLVVDLGHLYALRAFRVLRSWRTVTIVPGWRT
IVDALSLSITSLKDLVLLLLFSLFVFAVLGLQIYMGVLTQ
KCVKHFPADGSWGNFTDERWFNYTSNSSHWYIPDDWIEYP
LCGNSSGAGMCPPGYTCLQGYGGNPNYGYTSFDTFGWAFL
SVFRLVTLDYWEDLYQLALRSAGPWHILFFIIVVFYGTFC
FLNFILAVVVMSYTHMVKRADEEKAAERECVPWQKLQGAI
GAVVLSPFFELFIAVIIVLNITFMALDHHDMNIEFERILR
TGNYIFTSIYIVEAVLKIIALSPKFYFKDSWNVFDFIIVV
FAILELGLEGVQGLSVFRSFRLLRVFRLAKFWPTLNNFMS
VMTKSYGAFVNVMYVMFLLLFIFAIIGMQLFGMNYIDNME
RFPDGDLPRWNFTDFLHSFMIVFRALCGEWIESMWDCMLV
GDWSCIPFFVAVFFVGNLVILNLLIALLLNNYGSARDSSV
QRMWSNIRRVCFLLAKNKYFQKFVTAVLVITSVLLALEDI
YLPQRPVLVNITLYVDYVLTAFFVIEMIIMLFAVGFKKYF
TSKWYWLDFIVVVAYLLNFVLMCAGIEALQTLRLLRVFRL
FRPLSKVNGMQVVTSTLVEAVPHIFNVILVGIFFWLVFAI
MGVQLFAGKFYKCVDENSTVLSHEITMDRNDCLHENYTWE
NSPMNFDHVGNAYLSLLQVATFKGWLQIMNDAIDSREVHK
QPIRETNIYMYLYFIFFIVFGSFFILKLFVCILIDIFRQQ
RRKAEGLSATDSRTQLIYRRAVMRTMSAKPVKRIPKPTCH
PQSLMYDISVNRKFEYTMMILIILNVAVMAIDHYGQSMEF
SEVLDYLNLIFIIIFFVECVIKVSGLRHHYFKDPWNIIDF
LYVVLAIAGLMLSDVIEKYFISPTLLRILRILRVGRLLRY
FQSARGMRLLLLALRKALRTLFNVSFLLFVIMFVYAVFGM
EFFMHIRDAGAIDDVYNFKTFGQSIILLFQLATSAGWDGV
YFAIANEEDCRAPDHELGYPGNCGSRALGIAYLVSYLIIT
CLVVINMYAAVILDYVLEVYEDSKEGLTDDDYDMFFEVWQ
QFDPEATQYIRYDQLSELLEALQPPLQVQKPNKYKILSMN
IPICKDDHIFYKDVLEALVKDVFSRRGSPVEAGDVQAPNV
DEA
B:  SAKDGDVEGPAGCKKYDVECDSGECCQKQYLWYKWRPLDC
RCLKSGFFSSKCVCRDV
Description (1)  Sodium channel protein PaFPC1, Mu-diguetoxin-Dc1a


Functional site
1) chain B
residue 21
type SITE
sequence D
description Interacts with insect Nav channel => ECO:0000269|PubMed:30049784
source Swiss-Prot : SWS_FT_FI1
2) chain A
residue 1109-1171
type SITE
sequence CILIDIFRQQRRKAEGLSATDSRTQLIYRRAVMRTMSAKP
VKRIPKPTCHPQSLMYDISVNRK
description Interacts with insect Nav channel => ECO:0000269|PubMed:30049784
source Swiss-Prot : SWS_FT_FI1
3) chain A
residue 1220-1231
type SITE
sequence KVSGLRHHYFKD
description Interacts with insect Nav channel => ECO:0000269|PubMed:30049784
source Swiss-Prot : SWS_FT_FI1
4) chain A
residue 1280-1298
type SITE
sequence QSARGMRLLLLALRKALRT
description Interacts with insect Nav channel => ECO:0000269|PubMed:30049784
source Swiss-Prot : SWS_FT_FI1
5) chain B
residue 33
type SITE
sequence Y
description Interacts with insect Nav channel => ECO:0000269|PubMed:30049784
source Swiss-Prot : SWS_FT_FI1
6) chain B
residue 41
type SITE
sequence R
description Interacts with insect Nav channel => ECO:0000269|PubMed:30049784
source Swiss-Prot : SWS_FT_FI1
7) chain B
residue 44
type SITE
sequence K
description Interacts with insect Nav channel => ECO:0000269|PubMed:30049784
source Swiss-Prot : SWS_FT_FI1
8) chain B
residue 48
type SITE
sequence F
description Interacts with insect Nav channel => ECO:0000269|PubMed:30049784
source Swiss-Prot : SWS_FT_FI1
9) chain B
residue 49
type SITE
sequence S
description Interacts with insect Nav channel => ECO:0000269|PubMed:30049784
source Swiss-Prot : SWS_FT_FI1
10) chain B
residue 56
type SITE
sequence D
description Interacts with insect Nav channel => ECO:0000269|PubMed:30049784
source Swiss-Prot : SWS_FT_FI1
11) chain A
residue 908-921
type SITE
sequence MLFAVGFKKYFTSK
description Interacts with insect Nav channel => ECO:0000269|PubMed:30049784
source Swiss-Prot : SWS_FT_FI1
12) chain A
residue 965-981
type SITE
sequence VNGMQVVTSTLVEAVPH
description Interacts with insect Nav channel => ECO:0000269|PubMed:30049784
source Swiss-Prot : SWS_FT_FI1
13) chain A
residue 520-538
type TRANSMEM
sequence FFELFIAVIIVLNITFMAL
description Helical; Name=S1 of repeat II => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI10
14) chain A
residue 550-569
type TRANSMEM
sequence ILRTGNYIFTSIYIVEAVLK
description Helical; Name=S2 of repeat II => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI11
15) chain A
residue 584-603
type TRANSMEM
sequence NVFDFIIVVFAILELGLEGV
description Helical; Name=S3 of repeat II => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI12
16) chain A
residue 606-623
type TRANSMEM
sequence LSVFRSFRLLRVFRLAKF
description Helical; Name=S4 of repeat II => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI13
17) chain A
residue 640-658
type TRANSMEM
sequence AFVNVMYVMFLLLFIFAII
description Helical; Name=S5 of repeat II => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI14
18) chain A
residue 720-740
type TRANSMEM
sequence FFVAVFFVGNLVILNLLIALL
description Helical; Name=S6 of repeat II => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI15
19) chain A
residue 858-875
type TRANSMEM
sequence FQKFVTAVLVITSVLLAL
description Helical; Name=S1 of repeat III => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI16
20) chain A
residue 889-907
type TRANSMEM
sequence ITLYVDYVLTAFFVIEMII
description Helical; Name=S2 of repeat III => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI17
21) chain A
residue 922-940
type TRANSMEM
sequence WYWLDFIVVVAYLLNFVLM
description Helical; Name=S3 of repeat III => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI18
22) chain A
residue 261-280
type TRANSMEM
sequence LVLLLLFSLFVFAVLGLQIY
description Helical; Name=S5 of repeat I => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI7
23) chain A
residue 361-385
type INTRAMEM
sequence FGWAFLSVFRLVTLDYWEDLYQLAL
description Pore-forming => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI8
24) chain A
residue 687-707
type INTRAMEM
sequence FLHSFMIVFRALCGEWIESMW
description Pore-forming => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI8
25) chain A
residue 1048-1069
type INTRAMEM
sequence GNAYLSLLQVATFKGWLQIMND
description Pore-forming => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI8
26) chain A
residue 1339-1361
type INTRAMEM
sequence FGQSIILLFQLATSAGWDGVYFA
description Pore-forming => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI8
27) chain A
residue 393-413
type TRANSMEM
sequence ILFFIIVVFYGTFCFLNFILA
description Helical; Name=S6 of repeat I => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI9
28) chain A
residue 701
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:30049784, ECO:0007744|PDB:6A95
source Swiss-Prot : SWS_FT_FI29
29) chain A
residue 704
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:30049784, ECO:0007744|PDB:6A95
source Swiss-Prot : SWS_FT_FI29
30) chain A
residue 1062
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:30049784, ECO:0007744|PDB:6A95
source Swiss-Prot : SWS_FT_FI29
31) chain A
residue 1354
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:30049784, ECO:0007744|PDB:6A95
source Swiss-Prot : SWS_FT_FI29
32) chain A
residue 1356
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:30049784, ECO:0007744|PDB:6A95
source Swiss-Prot : SWS_FT_FI29
33) chain A
residue 539
type SITE
sequence D
description Interacts with the spider Mu-diguetoxin-Dc1a => ECO:0000269|PubMed:30049784
source Swiss-Prot : SWS_FT_FI30
34) chain A
residue 542
type SITE
sequence D
description Interacts with the spider Mu-diguetoxin-Dc1a => ECO:0000269|PubMed:30049784
source Swiss-Prot : SWS_FT_FI30
35) chain A
residue 549
type SITE
sequence R
description Interacts with the spider Mu-diguetoxin-Dc1a => ECO:0000269|PubMed:30049784
source Swiss-Prot : SWS_FT_FI30
36) chain A
residue 613
type SITE
sequence R
description Interacts with the spider Mu-diguetoxin-Dc1a => ECO:0000269|PubMed:30049784
source Swiss-Prot : SWS_FT_FI30
37) chain A
residue 1002
type SITE
sequence Q
description Interacts with the spider Mu-diguetoxin-Dc1a => ECO:0000269|PubMed:30049784
source Swiss-Prot : SWS_FT_FI30
38) chain A
residue 1027
type SITE
sequence R
description Interacts with the spider Mu-diguetoxin-Dc1a => ECO:0000269|PubMed:30049784
source Swiss-Prot : SWS_FT_FI30
39) chain A
residue 1032
type SITE
sequence H
description Interacts with the spider Mu-diguetoxin-Dc1a => ECO:0000269|PubMed:30049784
source Swiss-Prot : SWS_FT_FI30
40) chain A
residue 300
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI31
41) chain A
residue 946-964
type TRANSMEM
sequence ALQTLRLLRVFRLFRPLSK
description Helical; Name=S4 of repeat III => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI19
42) chain A
residue 141-159
type TRANSMEM
sequence IFSYFIMITILIHCIFMIM
description Helical; Name=S1 of repeat I => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI2
43) chain A
residue 982-1001
type TRANSMEM
sequence IFNVILVGIFFWLVFAIMGV
description Helical; Name=S5 of repeat III => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI20
44) chain A
residue 1087-1108
type TRANSMEM
sequence YMYLYFIFFIVFGSFFILKLFV
description Helical; Name=S6 of repeat III => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI21
45) chain A
residue 1172-1189
type TRANSMEM
sequence FEYTMMILIILNVAVMAI
description Helical; Name=S1 of repeat IV => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI22
46) chain A
residue 1201-1219
type TRANSMEM
sequence VLDYLNLIFIIIFFVECVI
description Helical; Name=S2 of repeat IV => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI23
47) chain A
residue 1232-1249
type TRANSMEM
sequence PWNIIDFLYVVLAIAGLM
description Helical; Name=S3 of repeat IV => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI24
48) chain A
residue 1263-1279
type TRANSMEM
sequence LLRILRILRVGRLLRYF
description Helical; Name=S4 of repeat IV => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI25
49) chain A
residue 1299-1316
type TRANSMEM
sequence LFNVSFLLFVIMFVYAVF
description Helical; Name=S5 of repeat IV => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI26
50) chain A
residue 1388-1410
type TRANSMEM
sequence IAYLVSYLIITCLVVINMYAAVI
description Helical; Name=S6 of repeat IV => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI27
51) chain A
residue 160-165
type TOPO_DOM
sequence PATQTT
description Extracellular => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI3
52) chain A
residue 941-945
type TOPO_DOM
sequence CAGIE
description Extracellular => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI3
53) chain A
residue 1002-1047
type TOPO_DOM
sequence QLFAGKFYKCVDENSTVLSHEITMDRNDCLHENYTWENSP
MNFDHV
description Extracellular => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI3
54) chain A
residue 1070-1086
type TOPO_DOM
sequence AIDSREVHKQPIRETNI
description Extracellular => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI3
55) chain A
residue 1190-1200
type TOPO_DOM
sequence DHYGQSMEFSE
description Extracellular => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI3
56) chain A
residue 1250-1262
type TOPO_DOM
sequence LSDVIEKYFISPT
description Extracellular => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI3
57) chain A
residue 1317-1338
type TOPO_DOM
sequence GMEFFMHIRDAGAIDDVYNFKT
description Extracellular => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI3
58) chain A
residue 1362-1387
type TOPO_DOM
sequence IANEEDCRAPDHELGYPGNCGSRALG
description Extracellular => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI3
59) chain A
residue 219-224
type TOPO_DOM
sequence DLGHLY
description Extracellular => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI3
60) chain A
residue 281-360
type TOPO_DOM
sequence MGVLTQKCVKHFPADGSWGNFTDERWFNYTSNSSHWYIPD
DWIEYPLCGNSSGAGMCPPGYTCLQGYGGNPNYGYTSFDT
description Extracellular => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI3
61) chain A
residue 386-392
type TOPO_DOM
sequence RSAGPWH
description Extracellular => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI3
62) chain A
residue 539-549
type TOPO_DOM
sequence DHHDMNIEFER
description Extracellular => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI3
63) chain A
residue 604-605
type TOPO_DOM
sequence QG
description Extracellular => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI3
64) chain A
residue 659-686
type TOPO_DOM
sequence GMQLFGMNYIDNMERFPDGDLPRWNFTD
description Extracellular => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI3
65) chain A
residue 708-719
type TOPO_DOM
sequence DCMLVGDWSCIP
description Extracellular => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI3
66) chain A
residue 876-888
type TOPO_DOM
sequence EDIYLPQRPVLVN
description Extracellular => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI3
67) chain A
residue 166-186
type TRANSMEM
sequence YILELVFLSIYTIEVVVKVLA
description Helical; Name=S2 of repeat I => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI4
68) chain A
residue 201-218
type TRANSMEM
sequence WNWLDFLVTLIGYITLVV
description Helical; Name=S3 of repeat I => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI5
69) chain A
residue 225-241
type TRANSMEM
sequence ALRAFRVLRSWRTVTIV
description Helical; Name=S4 of repeat I => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI6
70) chain A
residue 683
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498
source Swiss-Prot : SWS_FT_FI33
71) chain A
residue 378
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:30049784, ECO:0007744|PDB:6A91
source Swiss-Prot : SWS_FT_FI28
72) chain A
residue 1063
type BINDING
sequence W
description BINDING => ECO:0000269|PubMed:30049784, ECO:0007744|PDB:6A91
source Swiss-Prot : SWS_FT_FI28
73) chain A
residue 308
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:28183995, ECO:0000269|PubMed:30049784, ECO:0007744|PDB:5X0M, ECO:0007744|PDB:6A90, ECO:0007744|PDB:6A91, ECO:0007744|PDB:6A95
source Swiss-Prot : SWS_FT_FI32
74) chain A
residue 312
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:28183995, ECO:0000269|PubMed:30049784, ECO:0007744|PDB:5X0M, ECO:0007744|PDB:6A90, ECO:0007744|PDB:6A91, ECO:0007744|PDB:6A95
source Swiss-Prot : SWS_FT_FI32
75) chain A
residue 330
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:28183995, ECO:0000269|PubMed:30049784, ECO:0007744|PDB:5X0M, ECO:0007744|PDB:6A90, ECO:0007744|PDB:6A91, ECO:0007744|PDB:6A95
source Swiss-Prot : SWS_FT_FI32
76) chain A
residue 1015
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:28183995, ECO:0000269|PubMed:30049784, ECO:0007744|PDB:5X0M, ECO:0007744|PDB:6A90, ECO:0007744|PDB:6A91, ECO:0007744|PDB:6A95
source Swiss-Prot : SWS_FT_FI32
77) chain A
residue 1034
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:28183995, ECO:0000269|PubMed:30049784, ECO:0007744|PDB:5X0M, ECO:0007744|PDB:6A90, ECO:0007744|PDB:6A91, ECO:0007744|PDB:6A95
source Swiss-Prot : SWS_FT_FI32
78) chain A
residue 1028
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine; atypical => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI34

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