eF-site ID 6a91-A
PDB Code 6a91
Chain A

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Title Complex of voltage-gated sodium channel NavPaS from American cockroach Periplaneta americana bound with saxitoxin and Dc1a
Classification MEMBRANE PROTEIN/TOXIN
Compound Sodium channel protein PaFPC1
Source (TXI92_DIGCA)
Sequence A:  DKGRGANKDRDGSAHPDQALEQGSRLPARMRNIFPAELAS
TPLEDFDPFYKNKKTFVVVTKAGDIFRFSGEKSLWMLDPF
TPIRRVAISTMVQPIFSYFIMITILIHCIFMIMPATQTTY
ILELVFLSIYTIEVVVKVLARGFILHPFAYLRDPWNWLDF
LVTLIGYITLVVDLGHLYALRAFRVLRSWRTVTIVPGWRT
IVDALSLSITSLKDLVLLLLFSLFVFAVLGLQIYMGVLTQ
KCVKHFPADGSWGNFTDERWFNYTSNSSHWYIPDDWIEYP
LCGNSSGAGMCPPGYTCLQGYGGNPNYGYTSFDTFGWAFL
SVFRLVTLDYWEDLYQLALRSAGPWHILFFIIVVFYGTFC
FLNFILAVVVMSYTHMVKRADEEKAAERECVPWQKLQGAI
GAVVLSPFFELFIAVIIVLNITFMALDHHDMNIEFERILR
TGNYIFTSIYIVEAVLKIIALSPKFYFKDSWNVFDFIIVV
FAILELGLEGVQGLSVFRSFRLLRVFRLAKFWPTLNNFMS
VMTKSYGAFVNVMYVMFLLLFIFAIIGMQLFGMNYIDNME
RFPDGDLPRWNFTDFLHSFMIVFRALCGEWIESMWDCMLV
GDWSCIPFFVAVFFVGNLVILNLLIALLLNNYGSARDSSV
QRMWSNIRRVCFLLAKNKYFQKFVTAVLVITSVLLALEDI
YLPQRPVLVNITLYVDYVLTAFFVIEMIIMLFAVGFKKYF
TSKWYWLDFIVVVAYLLNFVLMCAGIEALQTLRLLRVFRL
FRPLSKVNGMQVVTSTLVEAVPHIFNVILVGIFFWLVFAI
MGVQLFAGKFYKCVDENSTVLSHEITMDRNDCLHENYTWE
NSPMNFDHVGNAYLSLLQVATFKGWLQIMNDAIDSREVHK
QPIRETNIYMYLYFIFFIVFGSFFILKLFVCILIDIFRQQ
RRKAEGLSATDSRTQLIYRRAVMRTMSAKPVKRIPKPTCH
PQSLMYDISVNRKFEYTMMILIILNVAVMAIDHYGQSMEF
SEVLDYLNLIFIIIFFVECVIKVSGLRHHYFKDPWNIIDF
LYVVLAIAGLMLSDVIEKYFISPTLLRILRILRVGRLLRY
FQSARGMRLLLLALRKALRTLFNVSFLLFVIMFVYAVFGM
EFFMHIRDAGAIDDVYNFKTFGQSIILLFQLATSAGWDGV
YFAIANEEDCRAPDHELGYPGNCGSRALGIAYLVSYLIIT
CLVVINMYAAVILDYVLEVYEDSKEGLTDDDYDMFFEVWQ
QFDPEATQYIRYDQLSELLEALQPPLQVQKPNKYKILSMN
IPICKDDHIFYKDVLEALVKDVFSRRGSPVEAGDVQAPNV
DEA
Description (1)  Sodium channel protein PaFPC1, Mu-diguetoxin-Dc1a


Functional site

1) chain A
residue 1109-1171
type SITE
sequence CILIDIFRQQRRKAEGLSATDSRTQLIYRRAVMRTMSAKP
VKRIPKPTCHPQSLMYDISVNRK
description Interacts with insect Nav channel => ECO:0000269|PubMed:30049784
source Swiss-Prot : SWS_FT_FI1

2) chain A
residue 1220-1231
type SITE
sequence KVSGLRHHYFKD
description Interacts with insect Nav channel => ECO:0000269|PubMed:30049784
source Swiss-Prot : SWS_FT_FI1

3) chain A
residue 1280-1298
type SITE
sequence QSARGMRLLLLALRKALRT
description Interacts with insect Nav channel => ECO:0000269|PubMed:30049784
source Swiss-Prot : SWS_FT_FI1

4) chain A
residue 908-921
type SITE
sequence MLFAVGFKKYFTSK
description Interacts with insect Nav channel => ECO:0000269|PubMed:30049784
source Swiss-Prot : SWS_FT_FI1

5) chain A
residue 965-981
type SITE
sequence VNGMQVVTSTLVEAVPH
description Interacts with insect Nav channel => ECO:0000269|PubMed:30049784
source Swiss-Prot : SWS_FT_FI1

6) chain A
residue 520-538
type TRANSMEM
sequence FFELFIAVIIVLNITFMAL
description Helical; Name=S1 of repeat II => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI10

7) chain A
residue 550-569
type TRANSMEM
sequence ILRTGNYIFTSIYIVEAVLK
description Helical; Name=S2 of repeat II => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI11

8) chain A
residue 584-603
type TRANSMEM
sequence NVFDFIIVVFAILELGLEGV
description Helical; Name=S3 of repeat II => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI12

9) chain A
residue 606-623
type TRANSMEM
sequence LSVFRSFRLLRVFRLAKF
description Helical; Name=S4 of repeat II => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI13

10) chain A
residue 640-658
type TRANSMEM
sequence AFVNVMYVMFLLLFIFAII
description Helical; Name=S5 of repeat II => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI14

11) chain A
residue 720-740
type TRANSMEM
sequence FFVAVFFVGNLVILNLLIALL
description Helical; Name=S6 of repeat II => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI15

12) chain A
residue 858-875
type TRANSMEM
sequence FQKFVTAVLVITSVLLAL
description Helical; Name=S1 of repeat III => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI16

13) chain A
residue 889-907
type TRANSMEM
sequence ITLYVDYVLTAFFVIEMII
description Helical; Name=S2 of repeat III => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI17

14) chain A
residue 922-940
type TRANSMEM
sequence WYWLDFIVVVAYLLNFVLM
description Helical; Name=S3 of repeat III => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI18

15) chain A
residue 261-280
type TRANSMEM
sequence LVLLLLFSLFVFAVLGLQIY
description Helical; Name=S5 of repeat I => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI7

16) chain A
residue 361-385
type INTRAMEM
sequence FGWAFLSVFRLVTLDYWEDLYQLAL
description Pore-forming => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI8

17) chain A
residue 687-707
type INTRAMEM
sequence FLHSFMIVFRALCGEWIESMW
description Pore-forming => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI8

18) chain A
residue 1048-1069
type INTRAMEM
sequence GNAYLSLLQVATFKGWLQIMND
description Pore-forming => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI8

19) chain A
residue 1339-1361
type INTRAMEM
sequence FGQSIILLFQLATSAGWDGVYFA
description Pore-forming => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI8

20) chain A
residue 393-413
type TRANSMEM
sequence ILFFIIVVFYGTFCFLNFILA
description Helical; Name=S6 of repeat I => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI9

21) chain A
residue 701
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:30049784, ECO:0007744|PDB:6A95
source Swiss-Prot : SWS_FT_FI29

22) chain A
residue 704
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:30049784, ECO:0007744|PDB:6A95
source Swiss-Prot : SWS_FT_FI29

23) chain A
residue 1062
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:30049784, ECO:0007744|PDB:6A95
source Swiss-Prot : SWS_FT_FI29

24) chain A
residue 1354
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:30049784, ECO:0007744|PDB:6A95
source Swiss-Prot : SWS_FT_FI29

25) chain A
residue 1356
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:30049784, ECO:0007744|PDB:6A95
source Swiss-Prot : SWS_FT_FI29

26) chain A
residue 539
type SITE
sequence D
description Interacts with the spider Mu-diguetoxin-Dc1a => ECO:0000269|PubMed:30049784
source Swiss-Prot : SWS_FT_FI30

27) chain A
residue 542
type SITE
sequence D
description Interacts with the spider Mu-diguetoxin-Dc1a => ECO:0000269|PubMed:30049784
source Swiss-Prot : SWS_FT_FI30

28) chain A
residue 549
type SITE
sequence R
description Interacts with the spider Mu-diguetoxin-Dc1a => ECO:0000269|PubMed:30049784
source Swiss-Prot : SWS_FT_FI30

29) chain A
residue 613
type SITE
sequence R
description Interacts with the spider Mu-diguetoxin-Dc1a => ECO:0000269|PubMed:30049784
source Swiss-Prot : SWS_FT_FI30

30) chain A
residue 1002
type SITE
sequence Q
description Interacts with the spider Mu-diguetoxin-Dc1a => ECO:0000269|PubMed:30049784
source Swiss-Prot : SWS_FT_FI30

31) chain A
residue 1027
type SITE
sequence R
description Interacts with the spider Mu-diguetoxin-Dc1a => ECO:0000269|PubMed:30049784
source Swiss-Prot : SWS_FT_FI30

32) chain A
residue 1032
type SITE
sequence H
description Interacts with the spider Mu-diguetoxin-Dc1a => ECO:0000269|PubMed:30049784
source Swiss-Prot : SWS_FT_FI30

33) chain A
residue 300
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI31

34) chain A
residue 946-964
type TRANSMEM
sequence ALQTLRLLRVFRLFRPLSK
description Helical; Name=S4 of repeat III => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI19

35) chain A
residue 141-159
type TRANSMEM
sequence IFSYFIMITILIHCIFMIM
description Helical; Name=S1 of repeat I => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI2

36) chain A
residue 982-1001
type TRANSMEM
sequence IFNVILVGIFFWLVFAIMGV
description Helical; Name=S5 of repeat III => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI20

37) chain A
residue 1087-1108
type TRANSMEM
sequence YMYLYFIFFIVFGSFFILKLFV
description Helical; Name=S6 of repeat III => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI21

38) chain A
residue 1172-1189
type TRANSMEM
sequence FEYTMMILIILNVAVMAI
description Helical; Name=S1 of repeat IV => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI22

39) chain A
residue 1201-1219
type TRANSMEM
sequence VLDYLNLIFIIIFFVECVI
description Helical; Name=S2 of repeat IV => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI23

40) chain A
residue 1232-1249
type TRANSMEM
sequence PWNIIDFLYVVLAIAGLM
description Helical; Name=S3 of repeat IV => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI24

41) chain A
residue 1263-1279
type TRANSMEM
sequence LLRILRILRVGRLLRYF
description Helical; Name=S4 of repeat IV => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI25

42) chain A
residue 1299-1316
type TRANSMEM
sequence LFNVSFLLFVIMFVYAVF
description Helical; Name=S5 of repeat IV => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI26

43) chain A
residue 1388-1410
type TRANSMEM
sequence IAYLVSYLIITCLVVINMYAAVI
description Helical; Name=S6 of repeat IV => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI27

44) chain A
residue 160-165
type TOPO_DOM
sequence PATQTT
description Extracellular => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI3

45) chain A
residue 941-945
type TOPO_DOM
sequence CAGIE
description Extracellular => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI3

46) chain A
residue 1002-1047
type TOPO_DOM
sequence QLFAGKFYKCVDENSTVLSHEITMDRNDCLHENYTWENSP
MNFDHV
description Extracellular => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI3

47) chain A
residue 1070-1086
type TOPO_DOM
sequence AIDSREVHKQPIRETNI
description Extracellular => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI3

48) chain A
residue 1190-1200
type TOPO_DOM
sequence DHYGQSMEFSE
description Extracellular => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI3

49) chain A
residue 1250-1262
type TOPO_DOM
sequence LSDVIEKYFISPT
description Extracellular => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI3

50) chain A
residue 1317-1338
type TOPO_DOM
sequence GMEFFMHIRDAGAIDDVYNFKT
description Extracellular => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI3

51) chain A
residue 1362-1387
type TOPO_DOM
sequence IANEEDCRAPDHELGYPGNCGSRALG
description Extracellular => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI3

52) chain A
residue 219-224
type TOPO_DOM
sequence DLGHLY
description Extracellular => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI3

53) chain A
residue 281-360
type TOPO_DOM
sequence MGVLTQKCVKHFPADGSWGNFTDERWFNYTSNSSHWYIPD
DWIEYPLCGNSSGAGMCPPGYTCLQGYGGNPNYGYTSFDT
description Extracellular => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI3

54) chain A
residue 386-392
type TOPO_DOM
sequence RSAGPWH
description Extracellular => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI3

55) chain A
residue 539-549
type TOPO_DOM
sequence DHHDMNIEFER
description Extracellular => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI3

56) chain A
residue 604-605
type TOPO_DOM
sequence QG
description Extracellular => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI3

57) chain A
residue 659-686
type TOPO_DOM
sequence GMQLFGMNYIDNMERFPDGDLPRWNFTD
description Extracellular => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI3

58) chain A
residue 708-719
type TOPO_DOM
sequence DCMLVGDWSCIP
description Extracellular => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI3

59) chain A
residue 876-888
type TOPO_DOM
sequence EDIYLPQRPVLVN
description Extracellular => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI3

60) chain A
residue 166-186
type TRANSMEM
sequence YILELVFLSIYTIEVVVKVLA
description Helical; Name=S2 of repeat I => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI4

61) chain A
residue 201-218
type TRANSMEM
sequence WNWLDFLVTLIGYITLVV
description Helical; Name=S3 of repeat I => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI5

62) chain A
residue 225-241
type TRANSMEM
sequence ALRAFRVLRSWRTVTIV
description Helical; Name=S4 of repeat I => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI6

63) chain A
residue 683
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498
source Swiss-Prot : SWS_FT_FI33

64) chain A
residue 378
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:30049784, ECO:0007744|PDB:6A91
source Swiss-Prot : SWS_FT_FI28

65) chain A
residue 1063
type BINDING
sequence W
description BINDING => ECO:0000269|PubMed:30049784, ECO:0007744|PDB:6A91
source Swiss-Prot : SWS_FT_FI28

66) chain A
residue 308
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:28183995, ECO:0000269|PubMed:30049784, ECO:0007744|PDB:5X0M, ECO:0007744|PDB:6A90, ECO:0007744|PDB:6A91, ECO:0007744|PDB:6A95
source Swiss-Prot : SWS_FT_FI32

67) chain A
residue 312
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:28183995, ECO:0000269|PubMed:30049784, ECO:0007744|PDB:5X0M, ECO:0007744|PDB:6A90, ECO:0007744|PDB:6A91, ECO:0007744|PDB:6A95
source Swiss-Prot : SWS_FT_FI32

68) chain A
residue 330
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:28183995, ECO:0000269|PubMed:30049784, ECO:0007744|PDB:5X0M, ECO:0007744|PDB:6A90, ECO:0007744|PDB:6A91, ECO:0007744|PDB:6A95
source Swiss-Prot : SWS_FT_FI32

69) chain A
residue 1015
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:28183995, ECO:0000269|PubMed:30049784, ECO:0007744|PDB:5X0M, ECO:0007744|PDB:6A90, ECO:0007744|PDB:6A91, ECO:0007744|PDB:6A95
source Swiss-Prot : SWS_FT_FI32

70) chain A
residue 1034
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:28183995, ECO:0000269|PubMed:30049784, ECO:0007744|PDB:5X0M, ECO:0007744|PDB:6A90, ECO:0007744|PDB:6A91, ECO:0007744|PDB:6A95
source Swiss-Prot : SWS_FT_FI32

71) chain A
residue 1028
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine; atypical => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M
source Swiss-Prot : SWS_FT_FI34


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