eF-site ID 6a60-D PDB Code 6a60 Chain D click to enlarge Title Crystal structure of human FXR/RXR-LBD heterodimer bound to GW4064 and 9cRA and SRC1 Classification TRANSCRIPTION Compound Bile acid receptor Source (RXRA_HUMAN) Sequence D:  EDMPVERILEAELAVDPVTNICQAADKQLFTLVEWAKRIP HFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLA TGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTEL GCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHK YPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPI DTFLMEMLEA Description Functional site 1) chain D residue 268 type sequence I description binding site for residue 9CR D 501 source : AC2 2) chain D residue 271 type sequence A description binding site for residue 9CR D 501 source : AC2 3) chain D residue 275 type sequence Q description binding site for residue 9CR D 501 source : AC2 4) chain D residue 309 type sequence L description binding site for residue 9CR D 501 source : AC2 5) chain D residue 313 type sequence F description binding site for residue 9CR D 501 source : AC2 6) chain D residue 316 type sequence R description binding site for residue 9CR D 501 source : AC2 7) chain D residue 327 type sequence A description binding site for residue 9CR D 501 source : AC2 8) chain D residue 345 type sequence I description binding site for residue 9CR D 501 source : AC2 9) chain D residue 432 type sequence C description binding site for residue 9CR D 501 source : AC2

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