eF-site ID 6a60-ABDF PDB Code 6a60 Chain A, B, D, F click to enlarge Title Crystal structure of human FXR/RXR-LBD heterodimer bound to GW4064 and 9cRA and SRC1 Classification TRANSCRIPTION Compound Bile acid receptor Source (RXRA_HUMAN) Sequence A:  ELTPDQQTLLHFIMDSYNKQRMPQEITNKFSAEENFLILT EMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAM FLRSAEIFNKKLSDLLEERIRNSGISDEYITPMFSFYKSI GELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLL DVLQKLCKIHQPENPQHFAELLGRLTELRTFNHHHAEMLM SWRVNDHKFTPLLEEIWDV B:  KILHRLLQ D:  EDMPVERILEAELAVDPVTNICQAADKQLFTLVEWAKRIP HFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLA TGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTEL GCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHK YPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPI DTFLMEMLEA F:  RHKILHRLLQE Description Functional site 1) chain A residue 263 type sequence Q description binding site for residue 064 A 501 source : AC1 2) chain A residue 264 type sequence R description binding site for residue 064 A 501 source : AC1 3) chain A residue 294 type sequence H description binding site for residue 064 A 501 source : AC1 4) chain A residue 328 type sequence M description binding site for residue 064 A 501 source : AC1 5) chain A residue 329 type sequence F description binding site for residue 064 A 501 source : AC1 6) chain A residue 331 type sequence R description binding site for residue 064 A 501 source : AC1 7) chain A residue 332 type sequence S description binding site for residue 064 A 501 source : AC1 8) chain A residue 335 type sequence I description binding site for residue 064 A 501 source : AC1 9) chain A residue 365 type sequence M description binding site for residue 064 A 501 source : AC1 10) chain A residue 369 type sequence Y description binding site for residue 064 A 501 source : AC1 11) chain A residue 447 type sequence H description binding site for residue 064 A 501 source : AC1 12) chain A residue 454 type sequence W description binding site for residue 064 A 501 source : AC1 13) chain A residue 461 type sequence F description binding site for residue 064 A 501 source : AC1 14) chain A residue 465 type sequence L description binding site for residue 064 A 501 source : AC1 15) chain D residue 268 type sequence I description binding site for residue 9CR D 501 source : AC2 16) chain D residue 271 type sequence A description binding site for residue 9CR D 501 source : AC2 17) chain D residue 275 type sequence Q description binding site for residue 9CR D 501 source : AC2 18) chain D residue 309 type sequence L description binding site for residue 9CR D 501 source : AC2 19) chain D residue 313 type sequence F description binding site for residue 9CR D 501 source : AC2 20) chain D residue 316 type sequence R description binding site for residue 9CR D 501 source : AC2 21) chain D residue 327 type sequence A description binding site for residue 9CR D 501 source : AC2 22) chain D residue 345 type sequence I description binding site for residue 9CR D 501 source : AC2 23) chain D residue 432 type sequence C description binding site for residue 9CR D 501 source : AC2 24) chain A residue 369 type MOD_RES sequence Y description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI1 25) chain A residue 447 type MOD_RES sequence H description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI1

Display surface Download Links