eF-site ID 6a5y-ABDF PDB Code 6a5y Chain A, B, D, F click to enlarge Title Crystal structure of human FXR/RXR-LBD heterodimer bound to HNC143 and 9cRA and SRC1 Classification TRANSCRIPTION Compound Bile acid receptor Source (RXRA_HUMAN) Sequence A:  ELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEEN FLILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGS AVEAMFLRSAEIFNKKLPSGHSDLLEERIRNSGISDEYIT PMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREA VEKLQEPLLDVLQKLCKIHQPENPQHFAELLGRLTELRTF NHHHAEMLMSWRVNDHKFTPLLEEIWDV B:  HKILHRLLQE D:  EDMPVERILEAELAVEDPVTNICQAADKQLFTLVEWAKRI PHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILL ATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTE LGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKH KYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTP IDTFLMEMLEA F:  RHKILHRLLQEGS Description Functional site 1) chain A residue 265 type sequence M description binding site for residue 9R0 A 501 source : AC1 2) chain A residue 270 type sequence T description binding site for residue 9R0 A 501 source : AC1 3) chain A residue 273 type sequence I description binding site for residue 9R0 A 501 source : AC1 4) chain A residue 287 type sequence L description binding site for residue 9R0 A 501 source : AC1 5) chain A residue 288 type sequence T description binding site for residue 9R0 A 501 source : AC1 6) chain A residue 291 type sequence A description binding site for residue 9R0 A 501 source : AC1 7) chain A residue 328 type sequence M description binding site for residue 9R0 A 501 source : AC1 8) chain A residue 329 type sequence F description binding site for residue 9R0 A 501 source : AC1 9) chain A residue 332 type sequence S description binding site for residue 9R0 A 501 source : AC1 10) chain A residue 335 type sequence I description binding site for residue 9R0 A 501 source : AC1 11) chain A residue 341 type sequence P description binding site for residue 9R0 A 501 source : AC1 12) chain A residue 344 type sequence H description binding site for residue 9R0 A 501 source : AC1 13) chain A residue 348 type sequence L description binding site for residue 9R0 A 501 source : AC1 14) chain A residue 369 type sequence Y description binding site for residue 9R0 A 501 source : AC1 15) chain A residue 447 type sequence H description binding site for residue 9R0 A 501 source : AC1 16) chain A residue 454 type sequence W description binding site for residue 9R0 A 501 source : AC1 17) chain A residue 264 type sequence R description binding site for residue SO4 A 502 source : AC2 18) chain A residue 266 type sequence P description binding site for residue SO4 A 502 source : AC2 19) chain A residue 267 type sequence Q description binding site for residue SO4 A 502 source : AC2 20) chain D residue 268 type sequence I description binding site for residue 9CR D 501 source : AC3 21) chain D residue 271 type sequence A description binding site for residue 9CR D 501 source : AC3 22) chain D residue 275 type sequence Q description binding site for residue 9CR D 501 source : AC3 23) chain D residue 305 type sequence W description binding site for residue 9CR D 501 source : AC3 24) chain D residue 313 type sequence F description binding site for residue 9CR D 501 source : AC3 25) chain D residue 316 type sequence R description binding site for residue 9CR D 501 source : AC3 26) chain D residue 326 type sequence L description binding site for residue 9CR D 501 source : AC3 27) chain D residue 327 type sequence A description binding site for residue 9CR D 501 source : AC3 28) chain D residue 345 type sequence I description binding site for residue 9CR D 501 source : AC3 29) chain D residue 432 type sequence C description binding site for residue 9CR D 501 source : AC3 30) chain D residue 411 type sequence Q description binding site for residue PO4 D 502 source : AC4 31) chain D residue 412 type sequence P description binding site for residue PO4 D 502 source : AC4 32) chain D residue 413 type sequence G description binding site for residue PO4 D 502 source : AC4 33) chain D residue 414 type sequence R description binding site for residue PO4 D 502 source : AC4 34) chain D residue 417 type sequence K description binding site for residue PO4 D 502 source : AC4 35) chain A residue 444 type sequence N description binding site for residue SO4 D 503 source : AC5 36) chain D residue 348 type sequence R description binding site for residue SO4 D 503 source : AC5 37) chain D residue 427 type sequence S description binding site for residue SO4 D 503 source : AC5 38) chain A residue 369 type MOD_RES sequence Y description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI1 39) chain A residue 447 type MOD_RES sequence H description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI1 40) chain F residue 641 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI1

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