eF-site ID 6a5s-A
PDB Code 6a5s
Chain A

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Title Structure of 14-3-3 gamma in complex with TFEB 14-3-3 binding motif
Classification TRANSCRIPTION
Compound 14-3-3 protein gamma
Source (6A5S)
Sequence A:  VDREQLVQKARLAEQAERYDDMAAAMKNVTELNEPLSNEE
RNLLSVAYKNVVGARRSSWRVISSIEQKTNEKKIEMVRAY
REKIEKELEAVCQDVLSLLDNYLIKNCSETQYESKVFYLK
MKGDYYRYLAEVATGEKRATVVESSEKAYSEAHEISKEHM
QPTHPIRLGLALNYSVFYYEIQNAPEQACHLAKTAFDDAI
AELDTLNEDSYKDSTLIMQLLRDNLTLWTS
Description


Functional site

1) chain A
residue 120
type
sequence K
description binding site for residue NA A 301
source : AC1

2) chain A
residue 50
type
sequence K
description binding site for Ligand residues SEP E 6 through CYS E 7 bound to SER E 5
source : AC4

3) chain A
residue 57
type
sequence R
description binding site for Ligand residues SEP E 6 through CYS E 7 bound to SER E 5
source : AC4

4) chain A
residue 132
type
sequence R
description binding site for Ligand residues SEP E 6 through CYS E 7 bound to SER E 5
source : AC4

5) chain A
residue 133
type
sequence Y
description binding site for Ligand residues SEP E 6 through CYS E 7 bound to SER E 5
source : AC4

6) chain A
residue 174
type
sequence G
description binding site for Ligand residues SEP E 6 through CYS E 7 bound to SER E 5
source : AC4

7) chain A
residue 177
type
sequence L
description binding site for Ligand residues SEP E 6 through CYS E 7 bound to SER E 5
source : AC4

8) chain A
residue 178
type
sequence N
description binding site for Ligand residues SEP E 6 through CYS E 7 bound to SER E 5
source : AC4

9) chain A
residue 225
type
sequence L
description binding site for Ligand residues SEP E 6 through CYS E 7 bound to SER E 5
source : AC4

10) chain A
residue 42-52
type prosite
sequence RNLLSVAYKNV
description 1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV
source prosite : PS00796

11) chain A
residue 216-235
type prosite
sequence YKDSTLIMQLLRDNLTLWTS
description 1433_2 14-3-3 proteins signature 2. YKDSTLIMQLLRDNLTLWTS
source prosite : PS00797

12) chain A
residue 57
type SITE
sequence R
description Interaction with phosphoserine on interacting protein => ECO:0000269|PubMed:17085597
source Swiss-Prot : SWS_FT_FI1

13) chain A
residue 132
type SITE
sequence R
description Interaction with phosphoserine on interacting protein => ECO:0000269|PubMed:17085597
source Swiss-Prot : SWS_FT_FI1

14) chain A
residue 2
type MOD_RES
sequence V
description N-acetylvaline; partial => ECO:0000269|PubMed:14534293, ECO:0000269|Ref.7, ECO:0000269|Ref.9, ECO:0007744|PubMed:19413330
source Swiss-Prot : SWS_FT_FI3

15) chain A
residue 133
type MOD_RES
sequence Y
description Phosphotyrosine => ECO:0000250|UniProtKB:P61983
source Swiss-Prot : SWS_FT_FI5

16) chain A
residue 145
type MOD_RES
sequence T
description Phosphothreonine => ECO:0000269|Ref.7
source Swiss-Prot : SWS_FT_FI6

17) chain A
residue 215
type MOD_RES
sequence S
description Phosphoserine => ECO:0000250|UniProtKB:P61983
source Swiss-Prot : SWS_FT_FI7

18) chain A
residue 234
type MOD_RES
sequence T
description Phosphothreonine => ECO:0007744|PubMed:24275569
source Swiss-Prot : SWS_FT_FI8

19) chain A
residue 235
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:24275569
source Swiss-Prot : SWS_FT_FI9


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