eF-site ID 6a2m-B PDB Code 6a2m Chain B click to enlarge Title Crystal structure of wild type Plasmodium falciparum DHFR-TS complexed with BT2, NADPH, and dUMP Classification OXIDOREDUCTASE Compound Bifunctional dihydrofolate reductase-thymidylate synthase Source (A7UD81_PLAFA) Sequence B:  MMEQVCDVFDIYAICACCKVESKNEGKKNEVFNNYTFRGL GNKGVLPWKCNSLDMKYFCAVTTYVNESKYEKLKYKRCKY LNKETKLQNVVVMGRTSWESIPKKFKPLSNRINVILSRTL KKEDFDEDVYIINKVEDLIVLLGKLNYYKCFIIGGSVVYQ EFLEKKLIKKIYFTRINSTYECDVFFPEINENEYQIISVS DVYTSNNTTLDFIIYKKTNNDDEEEDDFVYFNFNKENSIH PNDFQIYNSLKYKYHPEYQYLNIIYDIMMNGNKQSDRTGV GVLSKFGYIMKFDLSQYFPLLTTKKLFLRGIIEELLWFIR GETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGP IYGFQWRHFGAEYTNMYDNYENKGVDQLKNIINLIKNDPT SRRILLCAWNVKDLDQMALPPCHILCQFYVFDGKLSCIMY QRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHVLG NAHVYNNHIDSLKIQLNRIPYPFPTLKLNPDIKNIEDFTI SDFTIQNYVHHEKISM Description Functional site 1) chain B residue 470 type sequence R description binding site for residue UMP A 703 source : AC3 2) chain B residue 471 type sequence R description binding site for residue UMP A 703 source : AC3 3) chain B residue 14 type sequence I description binding site for residue 9QR B 701 source : AC5 4) chain B residue 15 type sequence C description binding site for residue 9QR B 701 source : AC5 5) chain B residue 16 type sequence A description binding site for residue 9QR B 701 source : AC5 6) chain B residue 54 type sequence D description binding site for residue 9QR B 701 source : AC5 7) chain B residue 55 type sequence M description binding site for residue 9QR B 701 source : AC5 8) chain B residue 58 type sequence F description binding site for residue 9QR B 701 source : AC5 9) chain B residue 116 type sequence F description binding site for residue 9QR B 701 source : AC5 10) chain B residue 164 type sequence I description binding site for residue 9QR B 701 source : AC5 11) chain B residue 170 type sequence Y description binding site for residue 9QR B 701 source : AC5 12) chain B residue 185 type sequence T description binding site for residue 9QR B 701 source : AC5 13) chain B residue 15 type sequence C description binding site for residue NAP B 702 source : AC6 14) chain B residue 16 type sequence A description binding site for residue NAP B 702 source : AC6 15) chain B residue 40 type sequence L description binding site for residue NAP B 702 source : AC6 16) chain B residue 41 type sequence G description binding site for residue NAP B 702 source : AC6 17) chain B residue 44 type sequence G description binding site for residue NAP B 702 source : AC6 18) chain B residue 45 type sequence V description binding site for residue NAP B 702 source : AC6 19) chain B residue 46 type sequence L description binding site for residue NAP B 702 source : AC6 20) chain B residue 105 type sequence G description binding site for residue NAP B 702 source : AC6 21) chain B residue 106 type sequence R description binding site for residue NAP B 702 source : AC6 22) chain B residue 107 type sequence T description binding site for residue NAP B 702 source : AC6 23) chain B residue 108 type sequence S description binding site for residue NAP B 702 source : AC6 24) chain B residue 127 type sequence L description binding site for residue NAP B 702 source : AC6 25) chain B residue 128 type sequence S description binding site for residue NAP B 702 source : AC6 26) chain B residue 129 type sequence R description binding site for residue NAP B 702 source : AC6 27) chain B residue 130 type sequence T description binding site for residue NAP B 702 source : AC6 28) chain B residue 144 type sequence N description binding site for residue NAP B 702 source : AC6 29) chain B residue 164 type sequence I description binding site for residue NAP B 702 source : AC6 30) chain B residue 165 type sequence G description binding site for residue NAP B 702 source : AC6 31) chain B residue 166 type sequence G description binding site for residue NAP B 702 source : AC6 32) chain B residue 167 type sequence S description binding site for residue NAP B 702 source : AC6 33) chain B residue 168 type sequence V description binding site for residue NAP B 702 source : AC6 34) chain B residue 169 type sequence V description binding site for residue NAP B 702 source : AC6 35) chain B residue 170 type sequence Y description binding site for residue NAP B 702 source : AC6 36) chain B residue 172 type sequence E description binding site for residue NAP B 702 source : AC6 37) chain B residue 345 type sequence R description binding site for residue UMP B 703 source : AC7 38) chain B residue 490 type sequence C description binding site for residue UMP B 703 source : AC7 39) chain B residue 491 type sequence H description binding site for residue UMP B 703 source : AC7 40) chain B residue 509 type sequence Q description binding site for residue UMP B 703 source : AC7 41) chain B residue 510 type sequence R description binding site for residue UMP B 703 source : AC7 42) chain B residue 511 type sequence S description binding site for residue UMP B 703 source : AC7 43) chain B residue 513 type sequence D description binding site for residue UMP B 703 source : AC7 44) chain B residue 521 type sequence N description binding site for residue UMP B 703 source : AC7 45) chain B residue 551 type sequence H description binding site for residue UMP B 703 source : AC7 46) chain B residue 553 type sequence Y description binding site for residue UMP B 703 source : AC7 47) chain B residue 330 type sequence N description binding site for residue PO4 B 704 source : AC8 48) chain B residue 331 type sequence I description binding site for residue PO4 B 704 source : AC8 49) chain B residue 334 type sequence D description binding site for residue PO4 B 704 source : AC8 50) chain B residue 356 type sequence Y description binding site for residue PO4 B 704 source : AC8

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