eF-site ID 5zy6-AB PDB Code 5zy6 Chain A, B click to enlarge Title catechol methyltransferase spCOMT Classification TRANSFERASE Compound Probable catechol O-methyltransferase 1 Source (COMT1_SCHPO) Sequence A:  EKEQLFLQHIQNLPQERLDAIRGHPELVLKEIDEFTYPDG SGVRMCIGDVKGGFIVGKIRERKPKIMVELGGYLGYSAIL FGNEISKIPGGRYYSLEVNEDYAKIAYELVKLAGLDEIVT IMIGKACDSLVELQQKLLHQALDMVFIDHWKDLYVPDLRV IESLNMIAPGTLLVADNIITPGAPEYHKYVNMSPEERRGY QAKVRNVNGFDFIGRWDLIYKTETKEFDAVDVTECVGYAK B:  EKEQLFLQHIQNLPQERLDAIRGHPELVLKEIDEFTYPDG SGVRMCIGDVKGGFIVGKIRERKPKIMVELGGYLGYSAIL FGNEISKIPGGRYYSLEVNEDYAKIAYELVKLAGLDEIVT IMIGKACDSLVELQQKLLHKDLGFQALDMVFIDHWKDLYV PDLRVIESLNMIAPGTLLVADNIITPGAPEYHKYVNMSPE ERRGYQAKVRNVNGFDFIGRWDLIYKTETKEFEDAVDVTE CVGYA Description Functional site 1) chain A residue 54 type sequence M description binding site for residue SAM A 301 source : AC1 2) chain A residue 56 type sequence I description binding site for residue SAM A 301 source : AC1 3) chain A residue 80 type sequence G description binding site for residue SAM A 301 source : AC1 4) chain A residue 81 type sequence G description binding site for residue SAM A 301 source : AC1 5) chain A residue 82 type sequence Y description binding site for residue SAM A 301 source : AC1 6) chain A residue 85 type sequence Y description binding site for residue SAM A 301 source : AC1 7) chain A residue 86 type sequence S description binding site for residue SAM A 301 source : AC1 8) chain A residue 105 type sequence L description binding site for residue SAM A 301 source : AC1 9) chain A residue 106 type sequence E description binding site for residue SAM A 301 source : AC1 10) chain A residue 107 type sequence V description binding site for residue SAM A 301 source : AC1 11) chain A residue 111 type sequence Y description binding site for residue SAM A 301 source : AC1 12) chain A residue 135 type sequence A description binding site for residue SAM A 301 source : AC1 13) chain A residue 162 type sequence D description binding site for residue SAM A 301 source : AC1 14) chain A residue 163 type sequence H description binding site for residue SAM A 301 source : AC1 15) chain A residue 164 type sequence W description binding site for residue SAM A 301 source : AC1 16) chain A residue 167 type sequence L description binding site for residue SAM A 301 source : AC1 17) chain B residue 54 type sequence M description binding site for residue SAM B 301 source : AC2 18) chain B residue 56 type sequence I description binding site for residue SAM B 301 source : AC2 19) chain B residue 80 type sequence G description binding site for residue SAM B 301 source : AC2 20) chain B residue 81 type sequence G description binding site for residue SAM B 301 source : AC2 21) chain B residue 82 type sequence Y description binding site for residue SAM B 301 source : AC2 22) chain B residue 85 type sequence Y description binding site for residue SAM B 301 source : AC2 23) chain B residue 86 type sequence S description binding site for residue SAM B 301 source : AC2 24) chain B residue 105 type sequence L description binding site for residue SAM B 301 source : AC2 25) chain B residue 106 type sequence E description binding site for residue SAM B 301 source : AC2 26) chain B residue 107 type sequence V description binding site for residue SAM B 301 source : AC2 27) chain B residue 111 type sequence Y description binding site for residue SAM B 301 source : AC2 28) chain B residue 135 type sequence A description binding site for residue SAM B 301 source : AC2 29) chain B residue 162 type sequence D description binding site for residue SAM B 301 source : AC2 30) chain B residue 163 type sequence H description binding site for residue SAM B 301 source : AC2 31) chain B residue 164 type sequence W description binding site for residue SAM B 301 source : AC2 32) chain B residue 167 type sequence L description binding site for residue SAM B 301 source : AC2 33) chain A residue 56 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU01019 source Swiss-Prot : SWS_FT_FI1 34) chain B residue 86 type BINDING sequence S description BINDING => ECO:0000255|PROSITE-ProRule:PRU01019 source Swiss-Prot : SWS_FT_FI1 35) chain B residue 106 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU01019 source Swiss-Prot : SWS_FT_FI1 36) chain B residue 107 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU01019 source Swiss-Prot : SWS_FT_FI1 37) chain B residue 135 type BINDING sequence A description BINDING => ECO:0000255|PROSITE-ProRule:PRU01019 source Swiss-Prot : SWS_FT_FI1 38) chain B residue 162 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU01019 source Swiss-Prot : SWS_FT_FI1 39) chain A residue 78 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU01019 source Swiss-Prot : SWS_FT_FI1 40) chain A residue 86 type BINDING sequence S description BINDING => ECO:0000255|PROSITE-ProRule:PRU01019 source Swiss-Prot : SWS_FT_FI1 41) chain A residue 106 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU01019 source Swiss-Prot : SWS_FT_FI1 42) chain A residue 107 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU01019 source Swiss-Prot : SWS_FT_FI1 43) chain A residue 135 type BINDING sequence A description BINDING => ECO:0000255|PROSITE-ProRule:PRU01019 source Swiss-Prot : SWS_FT_FI1 44) chain A residue 162 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU01019 source Swiss-Prot : SWS_FT_FI1 45) chain B residue 56 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU01019 source Swiss-Prot : SWS_FT_FI1 46) chain B residue 78 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU01019 source Swiss-Prot : SWS_FT_FI1 47) chain A residue 165 type BINDING sequence K description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 48) chain A residue 190 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 49) chain A residue 191 type BINDING sequence N description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 50) chain B residue 165 type BINDING sequence K description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 51) chain B residue 190 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 52) chain B residue 191 type BINDING sequence N description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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