eF-site ID 5zxh-C
PDB Code 5zxh
Chain C

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Title The structure of MT189-tubulin complex
Classification STRUCTURAL PROTEIN
Compound Tubulin alpha-1B chain
Source (E1BQ43_CHICK)
Sequence C:  MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDK
TIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRT
GTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLD
RIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVD
YGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDC
AFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEK
AYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYR
GDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYA
KRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSV
Description (1)  Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, Tubulin tyrosine ligase


Functional site

1) chain C
residue 11
type
ligand
sequence Q
description binding site for residue GTP C 501
source : AD1

2) chain C
residue 12
type
ligand
sequence A
description binding site for residue GTP C 501
source : AD1

3) chain C
residue 15
type
ligand
sequence Q
description binding site for residue GTP C 501
source : AD1

4) chain C
residue 98
type
ligand
sequence D
description binding site for residue GTP C 501
source : AD1

5) chain C
residue 99
type
ligand
sequence A
description binding site for residue GTP C 501
source : AD1

6) chain C
residue 100
type
ligand
sequence A
description binding site for residue GTP C 501
source : AD1

7) chain C
residue 101
type
ligand
sequence N
description binding site for residue GTP C 501
source : AD1

8) chain C
residue 140
type
ligand
sequence S
description binding site for residue GTP C 501
source : AD1

9) chain C
residue 143
type
ligand
sequence G
description binding site for residue GTP C 501
source : AD1

10) chain C
residue 144
type
ligand
sequence G
description binding site for residue GTP C 501
source : AD1

11) chain C
residue 145
type
ligand
sequence T
description binding site for residue GTP C 501
source : AD1

12) chain C
residue 146
type
ligand
sequence G
description binding site for residue GTP C 501
source : AD1

13) chain C
residue 177
type
ligand
sequence V
description binding site for residue GTP C 501
source : AD1

14) chain C
residue 183
type
ligand
sequence E
description binding site for residue GTP C 501
source : AD1

15) chain C
residue 206
type
ligand
sequence N
description binding site for residue GTP C 501
source : AD1

16) chain C
residue 224
type
ligand
sequence Y
description binding site for residue GTP C 501
source : AD1

17) chain C
residue 228
type
ligand
sequence N
description binding site for residue GTP C 501
source : AD1

18) chain C
residue 231
type
ligand
sequence I
description binding site for residue GTP C 501
source : AD1

19) chain C
residue 39
type
ligand
sequence D
description binding site for residue CA C 503
source : AD3

20) chain C
residue 41
type
ligand
sequence T
description binding site for residue CA C 503
source : AD3

21) chain C
residue 44
type
ligand
sequence G
description binding site for residue CA C 503
source : AD3

22) chain C
residue 55
type
ligand
sequence E
description binding site for residue CA C 503
source : AD3

23) chain C
residue 179
type
ligand
sequence T
description binding site for residue 9LX D 503
source : AD6

24) chain C
residue 181
type
ligand
sequence V
description binding site for residue 9LX D 503
source : AD6

25) chain C
residue 9-12
type binding
ligand GTP: GUANOSINE-5'-TRIPHOSPHATE
sequence VGQA
description GUANOSINE-5'-TRIPHOSPHATE binding site
source pdb_hetatom : GTP_5zxh_C_501

26) chain C
residue 15-16
type binding
ligand GTP: GUANOSINE-5'-TRIPHOSPHATE
sequence QI
description GUANOSINE-5'-TRIPHOSPHATE binding site
source pdb_hetatom : GTP_5zxh_C_501

27) chain C
residue 69
type binding
ligand GTP: GUANOSINE-5'-TRIPHOSPHATE
sequence D
description GUANOSINE-5'-TRIPHOSPHATE binding site
source pdb_hetatom : GTP_5zxh_C_501

28) chain C
residue 98-102
type binding
ligand GTP: GUANOSINE-5'-TRIPHOSPHATE
sequence DAANN
description GUANOSINE-5'-TRIPHOSPHATE binding site
source pdb_hetatom : GTP_5zxh_C_501

29) chain C
residue 140
type binding
ligand GTP: GUANOSINE-5'-TRIPHOSPHATE
sequence S
description GUANOSINE-5'-TRIPHOSPHATE binding site
source pdb_hetatom : GTP_5zxh_C_501

30) chain C
residue 142-147
type binding
ligand GTP: GUANOSINE-5'-TRIPHOSPHATE
sequence GGGTGS
description GUANOSINE-5'-TRIPHOSPHATE binding site
source pdb_hetatom : GTP_5zxh_C_501

31) chain C
residue 171
type binding
ligand GTP: GUANOSINE-5'-TRIPHOSPHATE
sequence I
description GUANOSINE-5'-TRIPHOSPHATE binding site
source pdb_hetatom : GTP_5zxh_C_501

32) chain C
residue 173-174
type binding
ligand GTP: GUANOSINE-5'-TRIPHOSPHATE
sequence PA
description GUANOSINE-5'-TRIPHOSPHATE binding site
source pdb_hetatom : GTP_5zxh_C_501

33) chain C
residue 177-179
type binding
ligand GTP: GUANOSINE-5'-TRIPHOSPHATE
sequence VST
description GUANOSINE-5'-TRIPHOSPHATE binding site
source pdb_hetatom : GTP_5zxh_C_501

34) chain C
residue 183
type binding
ligand GTP: GUANOSINE-5'-TRIPHOSPHATE
sequence E
description GUANOSINE-5'-TRIPHOSPHATE binding site
source pdb_hetatom : GTP_5zxh_C_501

35) chain C
residue 206
type binding
ligand GTP: GUANOSINE-5'-TRIPHOSPHATE
sequence N
description GUANOSINE-5'-TRIPHOSPHATE binding site
source pdb_hetatom : GTP_5zxh_C_501

36) chain C
residue 224
type binding
ligand GTP: GUANOSINE-5'-TRIPHOSPHATE
sequence Y
description GUANOSINE-5'-TRIPHOSPHATE binding site
source pdb_hetatom : GTP_5zxh_C_501

37) chain C
residue 227-228
type binding
ligand GTP: GUANOSINE-5'-TRIPHOSPHATE
sequence LN
description GUANOSINE-5'-TRIPHOSPHATE binding site
source pdb_hetatom : GTP_5zxh_C_501

38) chain C
residue 231
type binding
ligand GTP: GUANOSINE-5'-TRIPHOSPHATE
sequence I
description GUANOSINE-5'-TRIPHOSPHATE binding site
source pdb_hetatom : GTP_5zxh_C_501

39) chain C
residue 178-181
type binding
ligand 9LX: 2-(6-fluoro-3-{[(4-methoxyphenyl)methyl]amino}imidazo[1,2-a]pyridin-2-yl)phenol
sequence STAV
description 2-(6-fluoro-3-{[(4-methoxyphenyl)methyl]amino}imidazo[1,2-a]pyridin-2-yl)phenol binding site
source pdb_hetatom : 9LX_5zxh_D_503


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