eF-site ID 5zxh-A
PDB Code 5zxh
Chain A

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Title The structure of MT189-tubulin complex
Classification STRUCTURAL PROTEIN
Compound Tubulin alpha-1B chain
Source (E1BQ43_CHICK)
Sequence A:  MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDK
TIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRT
GTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLD
RIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVD
YGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDC
AFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEK
AYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYR
GDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYA
KRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGV
Description (1)  Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, Tubulin tyrosine ligase


Functional site

1) chain A
residue 10
type
ligand
sequence G
description binding site for residue GTP A 501
source : AC1

2) chain A
residue 11
type
ligand
sequence Q
description binding site for residue GTP A 501
source : AC1

3) chain A
residue 12
type
ligand
sequence A
description binding site for residue GTP A 501
source : AC1

4) chain A
residue 15
type
ligand
sequence Q
description binding site for residue GTP A 501
source : AC1

5) chain A
residue 98
type
ligand
sequence D
description binding site for residue GTP A 501
source : AC1

6) chain A
residue 99
type
ligand
sequence A
description binding site for residue GTP A 501
source : AC1

7) chain A
residue 101
type
ligand
sequence N
description binding site for residue GTP A 501
source : AC1

8) chain A
residue 140
type
ligand
sequence S
description binding site for residue GTP A 501
source : AC1

9) chain A
residue 143
type
ligand
sequence G
description binding site for residue GTP A 501
source : AC1

10) chain A
residue 144
type
ligand
sequence G
description binding site for residue GTP A 501
source : AC1

11) chain A
residue 145
type
ligand
sequence T
description binding site for residue GTP A 501
source : AC1

12) chain A
residue 146
type
ligand
sequence G
description binding site for residue GTP A 501
source : AC1

13) chain A
residue 177
type
ligand
sequence V
description binding site for residue GTP A 501
source : AC1

14) chain A
residue 183
type
ligand
sequence E
description binding site for residue GTP A 501
source : AC1

15) chain A
residue 206
type
ligand
sequence N
description binding site for residue GTP A 501
source : AC1

16) chain A
residue 224
type
ligand
sequence Y
description binding site for residue GTP A 501
source : AC1

17) chain A
residue 228
type
ligand
sequence N
description binding site for residue GTP A 501
source : AC1

18) chain A
residue 231
type
ligand
sequence I
description binding site for residue GTP A 501
source : AC1

19) chain A
residue 39
type
ligand
sequence D
description binding site for residue CA A 503
source : AC3

20) chain A
residue 41
type
ligand
sequence T
description binding site for residue CA A 503
source : AC3

21) chain A
residue 44
type
ligand
sequence G
description binding site for residue CA A 503
source : AC3

22) chain A
residue 55
type
ligand
sequence E
description binding site for residue CA A 503
source : AC3

23) chain A
residue 179
type
ligand
sequence T
description binding site for residue 9LX B 506
source : AC9

24) chain A
residue 181
type
ligand
sequence V
description binding site for residue 9LX B 506
source : AC9

25) chain A
residue 9-12
type binding
ligand GTP: GUANOSINE-5'-TRIPHOSPHATE
sequence VGQA
description GUANOSINE-5'-TRIPHOSPHATE binding site
source pdb_hetatom : GTP_5zxh_A_501

26) chain A
residue 15-16
type binding
ligand GTP: GUANOSINE-5'-TRIPHOSPHATE
sequence QI
description GUANOSINE-5'-TRIPHOSPHATE binding site
source pdb_hetatom : GTP_5zxh_A_501

27) chain A
residue 69
type binding
ligand GTP: GUANOSINE-5'-TRIPHOSPHATE
sequence D
description GUANOSINE-5'-TRIPHOSPHATE binding site
source pdb_hetatom : GTP_5zxh_A_501

28) chain A
residue 98-102
type binding
ligand GTP: GUANOSINE-5'-TRIPHOSPHATE
sequence DAANN
description GUANOSINE-5'-TRIPHOSPHATE binding site
source pdb_hetatom : GTP_5zxh_A_501

29) chain A
residue 140
type binding
ligand GTP: GUANOSINE-5'-TRIPHOSPHATE
sequence S
description GUANOSINE-5'-TRIPHOSPHATE binding site
source pdb_hetatom : GTP_5zxh_A_501

30) chain A
residue 142-146
type binding
ligand GTP: GUANOSINE-5'-TRIPHOSPHATE
sequence GGGTG
description GUANOSINE-5'-TRIPHOSPHATE binding site
source pdb_hetatom : GTP_5zxh_A_501

31) chain A
residue 171
type binding
ligand GTP: GUANOSINE-5'-TRIPHOSPHATE
sequence I
description GUANOSINE-5'-TRIPHOSPHATE binding site
source pdb_hetatom : GTP_5zxh_A_501

32) chain A
residue 173-174
type binding
ligand GTP: GUANOSINE-5'-TRIPHOSPHATE
sequence PA
description GUANOSINE-5'-TRIPHOSPHATE binding site
source pdb_hetatom : GTP_5zxh_A_501

33) chain A
residue 177-179
type binding
ligand GTP: GUANOSINE-5'-TRIPHOSPHATE
sequence VST
description GUANOSINE-5'-TRIPHOSPHATE binding site
source pdb_hetatom : GTP_5zxh_A_501

34) chain A
residue 183
type binding
ligand GTP: GUANOSINE-5'-TRIPHOSPHATE
sequence E
description GUANOSINE-5'-TRIPHOSPHATE binding site
source pdb_hetatom : GTP_5zxh_A_501

35) chain A
residue 206
type binding
ligand GTP: GUANOSINE-5'-TRIPHOSPHATE
sequence N
description GUANOSINE-5'-TRIPHOSPHATE binding site
source pdb_hetatom : GTP_5zxh_A_501

36) chain A
residue 224
type binding
ligand GTP: GUANOSINE-5'-TRIPHOSPHATE
sequence Y
description GUANOSINE-5'-TRIPHOSPHATE binding site
source pdb_hetatom : GTP_5zxh_A_501

37) chain A
residue 227-228
type binding
ligand GTP: GUANOSINE-5'-TRIPHOSPHATE
sequence LN
description GUANOSINE-5'-TRIPHOSPHATE binding site
source pdb_hetatom : GTP_5zxh_A_501

38) chain A
residue 231
type binding
ligand GTP: GUANOSINE-5'-TRIPHOSPHATE
sequence I
description GUANOSINE-5'-TRIPHOSPHATE binding site
source pdb_hetatom : GTP_5zxh_A_501

39) chain A
residue 178-181
type binding
ligand 9LX: 2-(6-fluoro-3-{[(4-methoxyphenyl)methyl]amino}imidazo[1,2-a]pyridin-2-yl)phenol
sequence STAV
description 2-(6-fluoro-3-{[(4-methoxyphenyl)methyl]amino}imidazo[1,2-a]pyridin-2-yl)phenol binding site
source pdb_hetatom : 9LX_5zxh_B_506

40) chain A
residue 407
type binding
ligand MES: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
sequence W
description 2-(N-MORPHOLINO)-ETHANESULFONIC ACID binding site
source pdb_hetatom : MES_5zxh_B_503


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