eF-site ID 5zx3-ABCDEF PDB Code 5zx3 Chain A, B, C, D, E, F click to enlarge Title Mycobacterium tuberculosis RNA polymerase holoenzyme with ECF sigma factor sigma H Classification TRANSCRIPTION Compound DNA-directed RNA polymerase subunit alpha Source (SIGH_MYCTU) Sequence A:  ISQRPTLSEDVLTDNRSQFVIEPLEPGFGYTLGNSLRRTL LSSIPGAAVTSIRIDGVLHEFTTVPGVKEDVTEIILNLKS LVVSSEEDEPVTMYLRKQGPGEVTAGDIVPPAGVTVHNPG MHIATLNDKGKLEVELVVERGRGYVPAVQNRASGAEIGRI PVDSIYSPVLKVTYKVDATRVEQRTDFDKLILDVETKNSI SPRDALASAGKTLVELFGLAR B:  MLISQRPTLSEDVLTDNRSQFVIEPLEPGFGYTLGNSLRR TLLSSIPGAAVTSIRIDGVLHEFTTVPGVKEDVTEIILNL KSLVVSSEEDEPVTMYLRKQGPGEVTAGDIVPPAGVTVHN PGMHIATLNDKGKLEVELVVERGRGYVPAVSGAEIGRIPV DSIYSPVLKVTYKVDATRVEQRTDFDKLILDVETKNSISP RDALASAGKTLVELFGLARELNVEAEGIEIG C:  RPQSSSNNSVPGAPNRVSFAKLREPLEVPGLLDVQTDSFE WLIGSPRWRESAAERGDVNPVGGLEEVLYELSPIEDFSGS MSLSFSDPRFDDVKAPVDECKDKDMTYAAPLFVTAEFINN NTGEIKSQTVFMGDFPMMTEKGTFIINGTERVVVSQLVRS PGVYFDETIDKSTDKTLHSVKVIPSRGAWLEFIDRKRRQP VTVLLGFSEIMRSTLEKDNTVGTDEALLDIYRKLRPGEPP TKESAQTLLENLFFKEKRYDLARVGRYKVNKKLGLTEEDV VATIEYLVRLHEGQTTMTVPGGVEVPVETDDIDHFGNRRL RTVGELIQNQIRVGMSRMERVVRERMTTQDVEAITPQTLI NIRPVVAAIKEFFGTSQLSQFMDQNNPLSGLTHKRRLSAL GPGGLSRERAGLEVRDVHPSHYGRMCPIETPEGPNIGLIG SLSVYARVNPFGFIETPYRKVVDGVVSDEIVYLTADEEDR HVVAQANSPIDADGRFVEPRVLVRRKAGEVEYVPSSEVDY MDVSPRQMVSVATAMIPFLEHDDANRALMGANMQRQAVPL VRSEAPLVGTGMELRAAIDAGDVVVAEESGVIEEVSADYI TVMHDNGTRRTYRMRKFARSNHGTCANQCPIVDAGDRVEA GQVIADGPCTDDGEMALGKNLLVAIMPWEGHNYEDAIILS NRLVEEDVLTSIHIEEHEIDARDTKLGAEEITRDIPNISD EVLADLDERGIVRIGAEVRDGDILVGKVTPKGETELTPEE RLLRAIFGEKAREVRDTSLKVPHGESGKVIGIRVFSREDE DELPAGVNELVRVYVAQKRKISDGDKLAGRHGNKGVIGKI LPVEDMPFLADGTPVDIILNTHGVPRRMNIGQILETHLGW CAHSGWKVDAAKGVPDWAARLPDELLEAQPNAIVSTPVFD GAQEAELQGLLSCTLPNRDGDVLVDADGKAMLFDGRSGEP FPYPVTVGYMYIMKLHHLVDDKIHARSTGPYSMITQQPLG GKAQFGGQRFGEMECWAMQAYGAAYTLQELLTIKSDDTVG RVKVYEAIVKGENIPEPGIPESFKVLLKELQSLCLNVEVL SSDGAAIELREGEDEDLERAAANLG D:  LDVNFFDELRIGLATAEDIRQWSYGEVKKPETINYRTLKP EKDGLFCEKIFGPTRDWECYCGKYKRVRFKGIICERCGVE VTRAKVRRERMGHIELAAPVTHIWYFKGVPSRLGYLLDLA PKDLEKIIYFAAYVITSVDEEMRHNELSTLEAEMAVERKA VEDQRDGELEARAQKLEADLAELEAEGAKADARRKVRDGG EREMRQIRDRAQRELDRLEDIWSTFTKLAPKQLIVDENLY RELVDRYGEYFTGAMGAESIQKLIENFDIDAEAESLRDVI RNGKGQKKLRALKRLKVVAAFQQSGNSPMGMVLDAVPVIP PELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLIDLG APEIIVNNEKRMLQESVDALFDNGRRGRPVTGPGNRPLKS LSDLLKGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQC GLPKLMALELFKPFVMKRLVDLNHAQNIKSAKRMVERQRP QVWDVLEEVIAEHPVLLNRAPTLHRLGIQAFEPMLVEGKA IQLHPLVCEAFNADFDGDQMAVHLPLSAEAQAEARILMLS SNNILSPASGRPLAMPRLDMVTGLYYLTTEVPGDTGEYQP ASGDHPETGVYSSPAEAIMAADRGVLSVRAKIKVRLTQLR PPVEIEAELFGHSGWQPGDAWMAETTLGRVMFNELLPLGY PFVNKQMHKKVQAAIINDLAERYPMIVVAQTVDKLKDAGF YWATRSGVTVSMADVLVPPRKKEILDHYEERADKVEKQFQ RGALNHDERNEALVEIWKEATDEVGQALREHYPDDNPIIT IVDSGATGNFTQTRTLAGMKGLVTNPKGEFIPRPVKSSFR EGLTVLEYFINTHGARKGLADTALRTADSGYLTRRLVDVS QDVIVREHDCQTERGIVVELAERAPDGTLIRDPYIETSAY ARTLGTDAVDEAGNVIVERGQDLGDPEIDALLAAGITQVK VRSVLTCATSTGVCATCYGRSMATGKLVDIGEAVGIVAAQ SIGEPGTQLTTGGLPRVQELFEARVPRGKAPIADVTGRVR LEDGERFYKITIVPDDGGEEVVYDKISKRQRLRVFKHEDG SERVLSDGDHVEVGQQLMEGSADPHEVLRVQGPREVQIHL VREVQEVYRAQGVSIHDKHIEVIVRQMLRRVTIIDSGSTE FLPGSLIDRAEFEAENAAGRPVLMGITKASLATDSWLSAA SFQETTRVLTDAAINCRSDKLNGLKENVIIGKLIPAGTGI NRYRNIAVQPTEEARAA E:  GGYDTPLGITNPPIDELLDRVSSKYALVIYAAKRARQIND YYNQLYVGPLVEPGLQEKPLSIALREIHADLLEHTE F:  DEELTARFERDAIPLLDQLYGGALRMTRNPADAEDLLQET MVKAYAGFRSFKAWLYRILTNTYINSYRKKQRQPAEYPTE QITDWQLASNAEHSSTGLRSAEVEALEALPDTEIKEALQA LPEEFRMAVYYADVEGFPYKEIAEIMDTPIGTVMSRLHRG RRQLRGLLADVAR Description Functional site 1) chain D residue 891 type sequence C description binding site for residue ZN D 2001 source : AC1 2) chain D residue 963 type sequence R description binding site for residue ZN D 2001 source : AC1 3) chain D residue 968 type sequence C description binding site for residue ZN D 2001 source : AC1 4) chain D residue 975 type sequence C description binding site for residue ZN D 2001 source : AC1 5) chain D residue 978 type sequence C description binding site for residue ZN D 2001 source : AC1 6) chain D residue 60 type sequence C description binding site for residue ZN D 2002 source : AC2 7) chain D residue 62 type sequence C description binding site for residue ZN D 2002 source : AC2 8) chain D residue 75 type sequence C description binding site for residue ZN D 2002 source : AC2 9) chain D residue 78 type sequence C description binding site for residue ZN D 2002 source : AC2 10) chain F residue 166-185 type DNA_BIND sequence YKEIAEIMDTPIGTVMSRLH description H-T-H motif => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 11) chain D residue 975 type DNA_BIND sequence C description H-T-H motif => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 12) chain D residue 978 type DNA_BIND sequence C description H-T-H motif => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 13) chain D residue 62 type DNA_BIND sequence C description H-T-H motif => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 14) chain D residue 75 type DNA_BIND sequence C description H-T-H motif => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 15) chain D residue 78 type DNA_BIND sequence C description H-T-H motif => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 16) chain D residue 535 type DNA_BIND sequence D description H-T-H motif => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 17) chain D residue 537 type DNA_BIND sequence D description H-T-H motif => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 18) chain D residue 539 type DNA_BIND sequence D description H-T-H motif => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 19) chain D residue 891 type DNA_BIND sequence C description H-T-H motif => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 20) chain D residue 968 type DNA_BIND sequence C description H-T-H motif => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 21) chain C residue 882-894 type prosite sequence GDKLAGRHGNKGV description RNA_POL_BETA RNA polymerases beta chain signature. GdKLAGrHGNKGV source prosite : PS01166 22) chain F residue 54-85 type prosite sequence AEDLLQETMVKAYAGFRSFKAWLYRI description SIGMA70_ECF Sigma-70 factors ECF subfamily signature. AEDLLQeTMVkAYagfrsfrhgtnlk.AWLyrI source prosite : PS01063

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