eF-site ID 5zx2-ABCDEF PDB Code 5zx2 Chain A, B, C, D, E, F click to enlarge Title Mycobacterium tuberculosis RNA polymerase transcription initiation complex with ECF sigma factor sigma H and 7nt RNA Classification TRANSCRIPTION/DNA/RNA Compound DNA-directed RNA polymerase subunit alpha Source (5ZX2) Sequence A:  QRPTLSEDVLTDNRSQFVIEPLEPGFGYTLGNSLRRTLLS SIPGAAVTSIRIDGVLHEFTTVPGVKEDVTEIILNLKSLV VSSEEDEPVTMYLRKQGPGEVTAGDIVPPAGVTVHNPGMH IATLNDKGKLEVELVVERGRGYVPAVQNRASGAEIGRIPV DSIYSPVLKVTYKVDATRTDFDKLILDVETKNSISPRDAL ASAGKTLVELFGLAR B:  MLISQRPTLSEDVLTDNRSQFVIEPLEPGFGYTLGNSLRR TLLSSIPGAAVTSIRIDGVLHEFTTVPGVKEDVTEIILNL KSLVVSSEEDEPVTMYLRKQGPGEVTAGDIVPPAGVTVHN PGMHIATLNDKGKLEVELVVERGRGYVPAVQNRASGAEIG RIPVDSIYSPVLKVTYKVDATRVEQRTDFDKLILDVETKN SISPRDALASAGKTLVELFGLARELNVEAEGIEI C:  SNNSVPGAPNRVSFAKLREPLEVPGLLDVQTDSFEWLIGS PRWRESAAERGDVNPVGGLEEVLYELSPIEDFSGSMSLSF SDPRFDDVKAPVDECKDKDMTYAAPLFVTAEFINNNTGEI KSQTVFMGDFPMMTEKGTFIINGTERVVVSQLVRSPGVYF DETIDKSTDKTLHSVKVIPSRGAWLEFDVDKRDTVGVRID RKRRQPVTVLLKALGWTSEQIVERFGFSEIMRSTLEKDNT VGTDEALLDIYRKLRPGEPPTKESAQTLLENLFFKEKRYD LARVGRYKVNKKLGLHVGEPITSSTLTEEDVVATIEYLVR LHEGQTTMTVPGGVEVPVETDDIDHFGNRRLRTVGELIQN QIRVGMSRMERVVRERMTTQDVEAITPQTLINIRPVVAAI KEFFGTSQLSQFMDQNNPLSGLTHKRRLSALGPGGLSRER AGLEVRDVHPSHYGRMCPIETPEGPNIGLIGSLSVYARVN PFGFIETPYRKVVDGVVSDEIVYLTADEEDRHVVAQANSP IDADGRFVEPRVLVRRKAGEVEYVPSSEVDYMDVSPRQMV SVATAMIPFLEHDDANRALMGANMQRQAVPLVRSEAPLVG TGMELRAAIDAGDVVVAEESGVIEEVSADYITVMHDNGTR RTYRMRKFARSNHGTCANQCPIVDAGDRVEAGQVIADGPC TDDGEMALGKNLLVAIMPWEGHNYEDAIILSNRLVEEDVL TSIHIEEHEIDARDTKLGAEEITRDIPNISDEVLADLDER GIVRIGAEVRDGDILVGKVTPKGETELTPEERLLRAIFGE KAREVRDTSLKVPHGESGKVIGIRVFSREDEDELPAGVNE LVRVYVAQKRKISDGDKLAGRHGNKGVIGKILPVEDMPFL ADGTPVDIILNTHGVPRRMNIGQILETHLGWCAHSGWKVD AAKGVPDWAARLPDELLEAQPNAIVSTPVFDGAQEAELQG LLSCTLPNRDGDVLVDADGKAMLFDGRSGEPFPYPVTVGY MYIMKLHHLVDDKIHARSTGPYSMITQQPLGGKAQFGGQR FGEMECWAMQAYGAAYTLQELLTIKSDDTVGRVKVYEAIV KGENIPEPGIPESFKVLLKELQSLCLNVEVLSSDGAAIEL REGEDEDLERAAANLGI D:  DVNFFDELRIGLATAEDIRQWSYGEVKKPETINYRTLKPE KDGLFCEKIFGPTRDWECYCGKYKRVRFKGIICERCGVEV TRAKVRRERMGHIELAAPVTHIWYFKGVPSRLGYLLDLAP KDLEKIIYFAAYVITSVDEEMRHNELSTLEAEMAVERKAV EDQRDGELEARAQKLEADLAELEAEGAKADARRKVRDGGE REMRQIRDRAQRELDRLEDIWSTFTKLAPKQLIVDENLYR ELVDRYGEYFTGAMGAESIQKLIENFDIDAEAESLRDVIR NGKGQKKLRALKRLKVVAAFQQSGNSPMGMVLDAVPVIPP ELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLIDLGA PEIIVNNEKRMLQESVDALFDNGRRGRPVTGPGNRPLKSL SDLLKGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCG LPKLMALELFKPFVMKRLVDLNHAQNIKSAKRMVERQRPQ VWDVLEEVIAEHPVLLNRAPTLHRLGIQAFEPMLVEGKAI QLHPLVCEAFNADFDGDQMAVHLPLSAEAQAEARILMLSS NNILSPASGRPLAMPRLDMVTGLYYLTTEVPGDTGEYQPA SGDHPETGVYSSPAEAIMAADRGVLSVRAKIKVRLTQLRP PVEIEAELFGHSGWQPGDAWMAETTLGRVMFNELLPLGYP FVNKQMHKKVQAAIINDLAERYPMIVVAQTVDKLKDAGFY WATRSGVTVSMADVLVPPRKKEILDHYEERADKVEKQFQR GALNHDERNEALVEIWKEATDEVGQALREHYPDDNPIITI VDSGATGNFTQTRTLAGMKGLVTNPKGEFIPRPVKSSFRE GLTVLEYFINTHGARKGLADTALRTADSGYLTRRLVDVSQ DVIVREHDCQTERGIVVELAERAPDGTLIRDPYIETSAYA RTLGTDAVDEAGNVIVERGQDLGDPEIDALLAAGITQVKV RSVLTCATSTGVCATCYGRSMATGKLVDIGEAVGIVAAQS IGEPGTQLTGGLPRVQELFEARVPRGKAPIADVTGRVRLE DGERFYKITIVPDDGGEEVVYDKISKRQRLRVFKHEDGSE RVLSDGDHVEVGQQLMEGSADPHEVLRVQGPREVQIHLVR EVQEVYRAQGVSIHDKHIEVIVRQMLRRVTIIDSGSTEFL PGSLIDRAEFEAENRRVEPAAGRPVLMGITKASLATDSWL SAASFQETTRVLTDAAINCRSDKLNGLKENVIIGKLIPAG TGINRYRNIAVQPTEEARAA E:  GYDTPLGITNPPIDELLDRVSSKYALVIYAAKRARQINDY YNQLYVGPLVEPGLQEKPLSIALREIHADLLEHTEG F:  DEELTARFERDAIPLLDQLYGGALRMTRNPADAEDLLQET MVKAYAGFRSFRHGTNLKAWLYRILTNTYINSYRKKQRQP AEYPTEQITDWQLASNAEHSSTGLRSAEVEALEALPDTEI KEALQALPEEFRMAVYYADVEGFPYKEIAEIMDTPIGTVM SRLHRGRRQLRGLLA Description Functional site 1) chain D residue 60 type sequence C description binding site for residue ZN D 2001 source : AC1 2) chain D residue 62 type sequence C description binding site for residue ZN D 2001 source : AC1 3) chain D residue 75 type sequence C description binding site for residue ZN D 2001 source : AC1 4) chain D residue 78 type sequence C description binding site for residue ZN D 2001 source : AC1 5) chain D residue 891 type sequence C description binding site for residue ZN D 2002 source : AC2 6) chain D residue 968 type sequence C description binding site for residue ZN D 2002 source : AC2 7) chain D residue 975 type sequence C description binding site for residue ZN D 2002 source : AC2 8) chain D residue 978 type sequence C description binding site for residue ZN D 2002 source : AC2 9) chain F residue 166-185 type DNA_BIND sequence YKEIAEIMDTPIGTVMSRLH description H-T-H motif => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 10) chain D residue 975 type DNA_BIND sequence C description H-T-H motif => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 11) chain D residue 978 type DNA_BIND sequence C description H-T-H motif => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 12) chain D residue 62 type DNA_BIND sequence C description H-T-H motif => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 13) chain D residue 75 type DNA_BIND sequence C description H-T-H motif => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 14) chain D residue 78 type DNA_BIND sequence C description H-T-H motif => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 15) chain D residue 535 type DNA_BIND sequence D description H-T-H motif => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 16) chain D residue 537 type DNA_BIND sequence D description H-T-H motif => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 17) chain D residue 539 type DNA_BIND sequence D description H-T-H motif => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 18) chain D residue 891 type DNA_BIND sequence C description H-T-H motif => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 19) chain D residue 968 type DNA_BIND sequence C description H-T-H motif => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 20) chain C residue 882-894 type prosite sequence GDKLAGRHGNKGV description RNA_POL_BETA RNA polymerases beta chain signature. GdKLAGrHGNKGV source prosite : PS01166 21) chain F residue 54-85 type prosite sequence AEDLLQETMVKAYAGFRSFRHGTNLKAWLYRI description SIGMA70_ECF Sigma-70 factors ECF subfamily signature. AEDLLQeTMVkAYagfrsfrhgtnlk.AWLyrI source prosite : PS01063

Display surface Download Links