eF-site ID 5zrf-CDEF PDB Code 5zrf Chain C, D, E, F click to enlarge Title Crystal structure of human topoisomerase II beta in complex with 5-iodouridine-containing-DNA and etoposide in space group p21 Classification ISOMERASE/DNA Compound DNA topoisomerase 2-beta Source (5ZRF) Sequence C:  AGCCGAGC D:  XGCAGCXCGGCX E:  AGCCGAGC F:  XGCAGCXCGGCX Description Functional site 1) chain D residue 12 type sequence A description binding site for residue EVP D 101 source : AC5 2) chain D residue 13 type sequence G description binding site for residue EVP D 101 source : AC5 3) chain E residue 8 type sequence C description binding site for residue EVP D 101 source : AC5 4) chain F residue 9 type sequence X description binding site for residue EVP D 101 source : AC5 5) chain F residue 10 type sequence G description binding site for residue EVP D 101 source : AC5 6) chain C residue 8 type sequence C description binding site for residue EVP F 1301 source : AC7 7) chain D residue 9 type sequence X description binding site for residue EVP F 1301 source : AC7 8) chain D residue 10 type sequence G description binding site for residue EVP F 1301 source : AC7 9) chain F residue 12 type sequence A description binding site for residue EVP F 1301 source : AC7 10) chain F residue 13 type sequence G description binding site for residue EVP F 1301 source : AC7 11) chain D residue 11 type sequence C description binding site for Di-nucleotide IU D 9 and DG D 10 source : AC9 12) chain F residue 10 type sequence G description binding site for Di-nucleotide IU D 9 and DG D 10 source : AC9 13) chain F residue 11 type sequence C description binding site for Di-nucleotide IU D 9 and DG D 10 source : AC9 14) chain F residue 12 type sequence A description binding site for Di-nucleotide IU D 9 and DG D 10 source : AC9 15) chain D residue 13 type sequence G description binding site for Di-nucleotide DC D 14 and IU D 15 source : AD1 16) chain D residue 16 type sequence C description binding site for Di-nucleotide DC D 14 and IU D 15 source : AD1 17) chain E residue 5 type sequence G description binding site for Di-nucleotide DC D 14 and IU D 15 source : AD1 18) chain E residue 6 type sequence A description binding site for Di-nucleotide DC D 14 and IU D 15 source : AD1 19) chain E residue 7 type sequence G description binding site for Di-nucleotide DC D 14 and IU D 15 source : AD1 20) chain D residue 14 type sequence C description binding site for Di-nucleotide IU D 15 and DC D 16 source : AD2 21) chain D residue 17 type sequence G description binding site for Di-nucleotide IU D 15 and DC D 16 source : AD2 22) chain E residue 4 type sequence C description binding site for Di-nucleotide IU D 15 and DC D 16 source : AD2 23) chain E residue 5 type sequence G description binding site for Di-nucleotide IU D 15 and DC D 16 source : AD2 24) chain E residue 6 type sequence A description binding site for Di-nucleotide IU D 15 and DC D 16 source : AD2 25) chain E residue 7 type sequence G description binding site for Di-nucleotide IU D 15 and DC D 16 source : AD2 26) chain D residue 18 type sequence G description binding site for Di-nucleotide DC D 19 and IU D 20 source : AD3 27) chain E residue 1 type sequence A description binding site for Di-nucleotide DC D 19 and IU D 20 source : AD3 28) chain E residue 2 type sequence G description binding site for Di-nucleotide DC D 19 and IU D 20 source : AD3 29) chain D residue 10 type sequence G description binding site for Di-nucleotide IU F 9 and DG F 10 source : AD4 30) chain D residue 11 type sequence C description binding site for Di-nucleotide IU F 9 and DG F 10 source : AD4 31) chain D residue 12 type sequence A description binding site for Di-nucleotide IU F 9 and DG F 10 source : AD4 32) chain F residue 11 type sequence C description binding site for Di-nucleotide IU F 9 and DG F 10 source : AD4 33) chain C residue 5 type sequence G description binding site for Di-nucleotide DC F 14 and IU F 15 source : AD5 34) chain C residue 6 type sequence A description binding site for Di-nucleotide DC F 14 and IU F 15 source : AD5 35) chain C residue 7 type sequence G description binding site for Di-nucleotide DC F 14 and IU F 15 source : AD5 36) chain F residue 13 type sequence G description binding site for Di-nucleotide DC F 14 and IU F 15 source : AD5 37) chain F residue 16 type sequence C description binding site for Di-nucleotide DC F 14 and IU F 15 source : AD5 38) chain C residue 5 type sequence G description binding site for Di-nucleotide IU F 15 and DC F 16 source : AD6 39) chain C residue 6 type sequence A description binding site for Di-nucleotide IU F 15 and DC F 16 source : AD6 40) chain C residue 7 type sequence G description binding site for Di-nucleotide IU F 15 and DC F 16 source : AD6 41) chain F residue 14 type sequence C description binding site for Di-nucleotide IU F 15 and DC F 16 source : AD6 42) chain F residue 17 type sequence G description binding site for Di-nucleotide IU F 15 and DC F 16 source : AD6 43) chain C residue 1 type sequence A description binding site for Di-nucleotide DC F 19 and IU F 20 source : AD7 44) chain C residue 2 type sequence G description binding site for Di-nucleotide DC F 19 and IU F 20 source : AD7 45) chain F residue 18 type sequence G description binding site for Di-nucleotide DC F 19 and IU F 20 source : AD7

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