eF-site ID 5zrf-A PDB Code 5zrf Chain A click to enlarge Title Crystal structure of human topoisomerase II beta in complex with 5-iodouridine-containing-DNA and etoposide in space group p21 Classification ISOMERASE/DNA Compound DNA topoisomerase 2-beta Source (5ZRF) Sequence A:  KGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGV IGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVG LQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLIN FIHHNWPSLLKHGFLEEFITKEAKEYFADMERHRILFRYA GPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHKHL TYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTC FKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQ NFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTL ARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGA EGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYK NFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQ VYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMT EEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYE TVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQAR FILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEA QEGPDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLK RKSPSDLWKEDLAAFVEELDKVESQERED Description Functional site 1) chain A residue 557 type sequence D description binding site for residue MG A 1301 source : AC1 2) chain A residue 559 type sequence D description binding site for residue MG A 1301 source : AC1 3) chain A residue 867 type sequence N description binding site for residue MG A 1302 source : AC2 4) chain A residue 868 type sequence G description binding site for residue MG A 1302 source : AC2 5) chain A residue 478 type sequence G description binding site for residue EVP F 1301 source : AC7 6) chain A residue 479 type sequence D description binding site for residue EVP F 1301 source : AC7 7) chain A residue 503 type sequence R description binding site for residue EVP F 1301 source : AC7 8) chain A residue 782 type sequence M description binding site for residue EVP F 1301 source : AC7 9) chain A residue 479 type sequence D description binding site for Di-nucleotide IU D 9 and DG D 10 source : AC9 10) chain A residue 897 type sequence D description binding site for Di-nucleotide DC D 19 and IU D 20 source : AD3 11) chain A residue 899 type sequence L description binding site for Di-nucleotide DC D 19 and IU D 20 source : AD3 12) chain A residue 821 type sequence Y description binding site for Di-nucleotide IU F 9 and DG F 10 source : AD4 13) chain A residue 505 type sequence K description binding site for Di-nucleotide DC F 14 and IU F 15 source : AD5 14) chain A residue 506 type sequence I description binding site for Di-nucleotide DC F 14 and IU F 15 source : AD5 15) chain A residue 507 type sequence L description binding site for Di-nucleotide DC F 14 and IU F 15 source : AD5 16) chain A residue 508 type sequence N description binding site for Di-nucleotide DC F 14 and IU F 15 source : AD5 17) chain A residue 516 type sequence Q description binding site for Di-nucleotide DC F 14 and IU F 15 source : AD5 18) chain A residue 564 type sequence H description binding site for Di-nucleotide DC F 14 and IU F 15 source : AD5 19) chain A residue 506 type sequence I description binding site for Di-nucleotide IU F 15 and DC F 16 source : AD6 20) chain A residue 507 type sequence L description binding site for Di-nucleotide IU F 15 and DC F 16 source : AD6 21) chain A residue 508 type sequence N description binding site for Di-nucleotide IU F 15 and DC F 16 source : AD6 22) chain A residue 564 type sequence H description binding site for Di-nucleotide IU F 15 and DC F 16 source : AD6 23) chain A residue 669 type sequence F description binding site for Di-nucleotide IU F 15 and DC F 16 source : AD6 24) chain A residue 872 type sequence I description binding site for Di-nucleotide IU F 15 and DC F 16 source : AD6 25) chain A residue 873 type sequence G description binding site for Di-nucleotide IU F 15 and DC F 16 source : AD6 26) chain A residue 874 type sequence T description binding site for Di-nucleotide IU F 15 and DC F 16 source : AD6 27) chain A residue 879 type sequence K description binding site for Di-nucleotide DC F 19 and IU F 20 source : AD7 28) chain A residue 1010 type sequence T description binding site for Di-nucleotide DC F 19 and IU F 20 source : AD7 29) chain A residue 1011 type sequence L description binding site for Di-nucleotide DC F 19 and IU F 20 source : AD7 30) chain A residue 1012 type sequence T description binding site for Di-nucleotide DC F 19 and IU F 20 source : AD7 31) chain A residue 1014 type sequence N description binding site for Di-nucleotide DC F 19 and IU F 20 source : AD7 32) chain A residue 1015 type sequence S description binding site for Di-nucleotide DC F 19 and IU F 20 source : AD7 33) chain A residue 641 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 34) chain A residue 671 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 35) chain A residue 707 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 36) chain A residue 1087 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI8 37) chain A residue 638 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI9 38) chain A residue 475-483 type prosite sequence LTEGDSAKS description TOPOISOMERASE_II DNA topoisomerase II signature. LTEGDSAKS source prosite : PS00177 39) chain A residue 821 type ACT_SITE sequence Y description O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01384, ECO:0000269|PubMed:21778401 source Swiss-Prot : SWS_FT_FI1 40) chain A residue 477 type BINDING sequence E description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995 source Swiss-Prot : SWS_FT_FI2 41) chain A residue 557 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995, ECO:0000269|PubMed:21778401 source Swiss-Prot : SWS_FT_FI3 42) chain A residue 559 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00995, ECO:0000269|PubMed:21778401 source Swiss-Prot : SWS_FT_FI3 43) chain A residue 505 type SITE sequence K description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 44) chain A residue 508 type SITE sequence N description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 45) chain A residue 677 type SITE sequence R description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 46) chain A residue 678 type SITE sequence K description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 47) chain A residue 739 type SITE sequence K description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 48) chain A residue 947 type SITE sequence W description Interaction with DNA source Swiss-Prot : SWS_FT_FI4 49) chain A residue 773 type SITE sequence Y description Interaction with DNA => ECO:0000255|PROSITE-ProRule:PRU00995 source Swiss-Prot : SWS_FT_FI5 50) chain A residue 820 type SITE sequence R description Transition state stabilizer source Swiss-Prot : SWS_FT_FI6 51) chain A residue 872 type SITE sequence I description Important for DNA bending; intercalates between base pairs of target DNA source Swiss-Prot : SWS_FT_FI7

Display surface Download Links